Tongzhang Zheng DSc

Susan Dwight Bliss Professor of Epidemiology (Environmental Health)

Research Interests

Environmental exposures, gene polymorphisms, gene-environment interaction and human health; Cancer epidemiology and etiology

Current Projects

  • Research Training for Study of Air Pollution Control in China
  • Environment, Gene and Testicular Cancer Risk
  • Modeling Interventions for Lung Cancer Mortality
  • Circadian Genes and Breast Cancer
  • Case-Control Study of Liver Cancer in China

Research Summary

Dr. Zheng’s research interests have been in the area of environmental pollution and human health, particularly in cancer epidemiology and etiology related to environmental hormone disruptors, genetic susceptibility and gene-environmental interaction. His research emphasizes the role of organochlorine compounds (such as PCBs, DDE and other pesticides) in the etiology of several major cancers in the United States including breast, Non-Hodgkin lymphoma, Hodgkin’s diseases, multiple myeloma and testicular cancer. Dr. Zheng has considerable experience in conducting epidemiological studies in China. He is the Principal Investigator (PI) for a National Institutes of Health (NIH) training grant studying air pollution and human health in China (including indoor air pollution and adverse birth outcomes; stove intervention and long-term health benefits in women and children). He is the PI for a NIH training grant for cancer epidemiology and biostatistics in China. He is also PI for a case-control study of liver cancer in China and serves as Co-Investigator for a case-control study of indoor pollution, gene polymorphisms and risk of lung cancer in Xuanwei County in China.


Selected Publications

  • Conde L, Halperin E, Brown KM, Smedby KE, Rothman N, Nieter A, Slager SL, Brooks-Wilson A, Agana L, Akers NK, Riby J, Adami H, Chang ET, Darabi H, Glimelius B, Hjalgri H, Humphreys K, Liu L, Low HQ, Melbye M, Cozen W, Davis S, Hartge P, Morton LM, Schenk M, Wang SS, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm S, Zhang Y, Zheng T, et al. Genome-wide association study identifies novel HLA-DQB1 risk alleles specific to follicular lymphoma. Nat Genet. 2010;42(8):661-4.
  • Hoffman A, Zheng T, Yi CH, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T, Zhu Y. microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis. Cancer Research 2009; 69(14): 5970-7 PMID: 19567675.
  • Wang R, Zhang Y, Lan Q, Holford TR, Leaderer B, SH Zahm, Dosemeci M, Rothman N, Boyle P, Zhu Y, Qin Q, and Zheng T. Occupational exposure to solvents and risks for non-Hodgkin’s lymphoma in Connecticut women Am J Epidemiol 2009; 15;169(2): 176-85. PMID: 19056833.
  • Shen M, Chapman RS, Vermeulen R, Tian L, Zheng T, et al. Coal Use, Stove Improvement, and Adult Pneumonia Mortality in Xuanwei, China: A Retrospective Cohort Study. Environ Health Perspect 2009; 117(2): 261-6
  • Chen Y, Zheng T, Lan Q, Foss F, Kim C, Chen X, Dai M, Li Y, Holford T, Leaderer B, Boyle P, Chanock S, Rothman N, Zhang Y. Cytokine polymorphisms in Th1/Th2 pathway, body mass index, and risk of non-Hodgkin lymphoma. Blood (in press).
  • Zheng T, Holford T, Mayne ST, Ward B, Carter D, Owens PH, Dubrow R, Zahm SH, Boyle P, Archibeque-Engle S, Tessari J. DDE and DDT in breast adipose tissue and risk of female breast cancer. Am J Epidemiol 1999; 150:453-458.
  • Zhang Y, Holford TR, Leaderer B, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Wise JP Sr, Qin Q, Kilfoy B, Han J, Zheng T. Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma. Am J Epidemiol. 2007;165(11):1255-64.
  • Zheng T, Holford TR, Leaderer B, Zhang Y, Zahm SH, Flynn S, Tallini G, Zhang B, Zhou K, Owens PH, Lan Q, Rothman N and Boyle, P. Diet and nutrient intakes and risk of non-Hodgkin’s lymphoma in Connecticut women. Am J Epidemiol 2004; 159:454-66.

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