Thomas Michael Gill, MD

Humana Foundation Professor of Medicine (Geriatrics) and Professor of Epidemiology (Chronic Diseases) and of Investigative Medicine; Director, Yale Program on Aging; Director, Claude D. Pepper Older Americans Independence Center; Director, Yale Center for Disability and Disabling Disorders; Director, Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research

Research Interests

Aging; Disability Evaluation; Epidemiology; Geriatrics; Geriatric Assessment; Clinical Trial

Public Health Interests

Aging; Chronic Conditions; Clinical Trials; Epidemiology Methods; Gerontology

Research Organizations

Internal Medicine: Geriatric Medicine

School of Public Health

Research Summary

Dr. Gill's research is directed towards understanding the mechanisms underlying the development of functional decline and disability among community-living older persons and towards developing preventive strategies to forestall the onset and progression of disability among those who are most vulnerable. The results from the Yale Precipitating Events Project (PEP), Dr. Gill's ongoing NIA-funded cohort study, which includes monthly assessments of functional status for over 16 years, are revolutionizing our understanding of disability, a problem of immense importance to older persons, their families, and society. In a landmark clinical trial, Dr. Gill's research group demonstrated that functional decline among frail older persons can be prevented through a prehabilitation program targeting underlying impairments in physical capabilities.

Extensive Research Description

Dr. Gill's research is directed towards understanding the mechanisms underlying the development of functional decline and disability among community-living older persons and towards developing preventive strategies to forestall the onset and progression of disability among those who are most vulnerable. The results from the Yale Precipitating Events Project(PEP), Dr. Gill's ongoing NIA-funded cohort study, which includes monthly assessments of functional status for over 16 years, are revolutionizing our understanding of disability, a problem of immense importance to older persons,their families, and society. In a landmark clinical trial, Dr. Gill's research group demonstrated that functional decline among frail older persons can be prevented through a prehabilitation program targeting underlying impairments in physical capabilities. Dr. Gill's other research interests include the epidemiology of frailty and the aging lung.

Current research includes three large multi-site clinical trials. The first is evaluating the effectiveness of a physical activity intervention inpreventing major mobility disability and other clinically relevant outcomes in at-risk older persons; the second is evaluating the benefit of testosterone treatment in symptomatic older men with low serum testosterone; while the third is testing the effectiveness of an individually tailored, multifactorial intervention to prevent serious fall injuries.

Dr. Gill directs the Center on Disability and Disabling Disorders, which conducts longitudinal studies and clinical trials to enhance the scientific knowledge base of the disablement process and to rigorously evaluate promising intervention strategies. The Center includes an expanding number of clinical investigators, across disciplines, who are pursuing aging research related to disability and disabling disorders. This includes functional assessment in general as well as the functional consequences of highly prevalent disease-specific conditions such as arthritis, heart failure, chronic obstructive pulmonary disease (COPD), influenza, diabetes, stroke, depression, and dementia.


1. Yale PEP Study: Epidemiology of Disability and Recovery in Older Persons?

2. STRIDE: Prevention of Serious Fall Injuries in Older Persons

3. LIFE Study: Physical Exercise to Prevent Disability

4. Testosterone Trial

Selected Publications

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Contact Info

Thomas Michael Gill, MD
Patient Care Locations
874 Howard Avenue
New Haven, CT 06519
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
Office Location
E.S. Harkness Memorial Hall, Building A
367 Cedar Street, Ste Rm 317a

New Haven, CT 06510
Mailing Address
20 York Street
New Haven, CT 06510

Curriculum Vitae

Yale Program on Aging