Tassos Constantino Kyriakides PhD
Associate Research Scientist in Medicine (AIDS) and in Public Health (Biostatistics)
Current Projects
- Analysis of data from a multi-national HIV therapy management clinical trial
- On-going clinical trial in repair strategies for abdominal aortic aneurysm
- On-going pilot HIV therapy trial
Research Summary
- Design, management, execution and data analysis of medical research projects (observational studies/randomized clinical trials)
- Infectious disease epidemiology background with emphasis on HIV treatment
- Teaching study design and methodology, epidemiology and statistical analysis
- Statistical analysis consultant
Selected Publications
- Lederle, FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM for the OVER Veteran Affairs Cooperative Study. Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm. NEJM 2012; 367 (21): 1988-1997
- Nicos Skordis, Elisavet Efstathiou, Tassos C. Kyriakides, Antria Savvidou, Savvas C. Savva, Leonidas A. Phylactou, Christos Shammas, Vassos Neocleous. Epidemiology of Type 1 diabetes mellitus in Cyprus: rising incidence at the dawn of the 21st century. Hormones 2012, 11(1):86-93
- Stroupe KT, Lederle FA, Matsumura JS, Kyriakides TC, Jonk YC, Ge Ling, Freischlag JA for the Open Versus Endovascular Repair (OVER) Veterans’ Affairs Cooperative Study Group. Journal of Vascular Surgery 2012; 56:901-10.
- Bedimo, R., Kyriakides, T., Brown, S., Weidler, J., Lie, Y., Coakley, E. and Holodniy, M. (2012), Predictive value of HIV-1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment-experienced patients. HIV Medicine. doi: 10.1111/j.1468-1293.2011.00981.x
- Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of treatment interruption and intensification of antiretroviral therapy on health-related quality of life in patients with advanced HIV: A randomized, controlled trial. Med Decis Making. 2012; 32(1):70-82.
- Contessa J., Nadzam G. and Kyriakides TC. Surgical Resident Attrition and the Menninger Morale Curve. Surgical Science, 2011 (2):397-401
- Contessa J., Kim D. and Kyriakides TC. Can Moral Reasoning Predict General Surgery Residents' Clinical Competence? Journal of Surgical Education. Available online August 2011, volume 69(1).
- Holodniy M, Brown ST, Cameron DW, Kyriakides TC, Angus B, et al. 2011 Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial. PLoS ONE 6(3): e14764. doi:10.1371/journal.pone.0014764
- Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of treatment interruption and intensification of antiretroviral therapy on health-related quality of life in patients with advanced HIV: A randomized, controlled trial. Med Decis Making. Prepublished March 7, 2011.
- Methodological Issues in Comparative Effectiveness Research: Clinical Trials Peter Peduzzi, Tassos Kyriakides, Theresa Z. O'Connor, Peter Guarino, Stuart R. Warren, Grant D. Huang. The American Journal of Medicine - December 2010 (Vol. 123, Issue 12, Supplement, Pages e8-e15, DOI: 10.1016/j.amjmed.2010.10.003)
Selected Publications
- Lederle, FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM for the OVER Veteran Affairs Cooperative Study. Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm. NEJM 2012; 367 (21): 1988-1997
- Nicos Skordis, Elisavet Efstathiou, Tassos C. Kyriakides, Antria Savvidou, Savvas C. Savva, Leonidas A. Phylactou, Christos Shammas, Vassos Neocleous. Epidemiology of Type 1 diabetes mellitus in Cyprus: rising incidence at the dawn of the 21st century. Hormones 2012, 11(1):86-93
- Stroupe KT, Lederle FA, Matsumura JS, Kyriakides TC, Jonk YC, Ge Ling, Freischlag JA for the Open Versus Endovascular Repair (OVER) Veterans’ Affairs Cooperative Study Group. Journal of Vascular Surgery 2012; 56:901-10.
- Bedimo, R., Kyriakides, T., Brown, S., Weidler, J., Lie, Y., Coakley, E. and Holodniy, M. (2012), Predictive value of HIV-1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment-experienced patients. HIV Medicine. doi: 10.1111/j.1468-1293.2011.00981.x
- Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of treatment interruption and intensification of antiretroviral therapy on health-related quality of life in patients with advanced HIV: A randomized, controlled trial. Med Decis Making. 2012; 32(1):70-82.
- Contessa J., Nadzam G. and Kyriakides TC. Surgical Resident Attrition and the Menninger Morale Curve. Surgical Science, 2011 (2):397-401
- Contessa J., Kim D. and Kyriakides TC. Can Moral Reasoning Predict General Surgery Residents' Clinical Competence? Journal of Surgical Education. Available online August 2011, volume 69(1).
- Holodniy M, Brown ST, Cameron DW, Kyriakides TC, Angus B, et al. 2011 Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial. PLoS ONE 6(3): e14764. doi:10.1371/journal.pone.0014764
- Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of treatment interruption and intensification of antiretroviral therapy on health-related quality of life in patients with advanced HIV: A randomized, controlled trial. Med Decis Making. Prepublished March 7, 2011.
- Methodological Issues in Comparative Effectiveness Research: Clinical Trials Peter Peduzzi, Tassos Kyriakides, Theresa Z. O'Connor, Peter Guarino, Stuart R. Warren, Grant D. Huang. The American Journal of Medicine - December 2010 (Vol. 123, Issue 12, Supplement, Pages e8-e15, DOI: 10.1016/j.amjmed.2010.10.003)
- Birgitt Dau, Dieter Ayers, Joel Singer, P. Richard Harrigan, Sheldon Brown, Tassos C. Kyriakides, D. William Cameron, Brian Angus, Mark Holodniy. Connection Domain Mutations in Treatment-Experienced Patients in the OPTIMA Trial. JAIDS 2010; 54(2): 160-166.
- Frank A. Lederle, Julie A. Freischlag, Tassos C. Kyriakides, Frank T. Padberg, Jon S. Matsumura, Ted R. Kohler, Peter H. Lin, Jessie M. Jean-Claude, Dolores F. Cikrit, Kathleen M. Swanson, Peter N. Peduzzi, for the Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Outcomes Following Endovascular vs. Open Repair of Abdominal Aortic Aneurysm. A Randomized Trial. JAMA 2009; 302 (14): 1535-1542.
- Aslam H. Anis, Bohdan Nosyk, Huiying Sun, Daphne P. Guh, Nick Bansback, Xin Li , Paul G. Barnett , Vilija Joyce , Kathleen M. Swanson , Tassos C. Kyriakides , Mark Holodniy, D. William Cameron, and Sheldon T. Brown, for the OPTIMA Team. Quality of Life of Patients with Advanced HIV/AIDS: Measuring the Impact of Both AIDS Defining Events and Non-AIDS Serious Adverse Events. JAIDS 2009; 51(5):631-639
- C. Bakhos, F. Alkhouri, T. Kyriakides, R. Reinhold, G. Nadzam. Early Post-Operative Hemorrhage After Open and Laparoscopic Roux-En-Y Gastric Bypass. Obesity Surgery 2009; 19(12):153-157.
- BVR Joyce, PG Barnett, AM Bayoumi, SC Griffin, TC Kyriakides, W Yu, V Sundaram, M Holodniy, ST Brown, W Cameron, M Youle, M Sculpher, AH Anis, DK Owens. Health-Related Quality of Life in a Randomized Trial of Antiretroviral Therapy for Advanced HIV Disease. JAIDS 2009; 50(1): 27-36
- NP Mastroyiannopoulos, E Chrysanthou, TC Kyriakides, JB Uney, MS Mahadevan and LA Phylactou. The effect of Myotonic Dystrophy Transcript Levels and Location on Muscle Differentiation. Biochemical & Biophysical Research Communications 2008; 377(2): 526-531.
- Desai S., Kyriakides T., Holodniy M., Al-Salman J., Griffith B., and Kozal M. Evolution of Genotypic Resistance Algorithms and Their Impact on the Interpretation of Clinical Trials: An OPTIMA Trial Substudy. HIV Clinical Trials 2007; 8(5):293-302
- Bakhos C, O’Connor J., Kyriakides T., Abou-Nukta F., Bonadies J., Vital Capacity as a Predictor of Outcome in Elderly Patients with Rib Fractures. Journal of Trauma-Injury, Infection and Critical Care 2006; 61(1):131-134
- Kyriakides TC., Babiker A., Singer J., Piaseczny M., Russo J. on behalf of the OPTIMA Team. Study Conduct, Monitoring and Data Management in a Tri-National AIDS Trial: The OPTIMA Model. Clinical Trials 2004; 1(3):277-281
- Kyriakides TC., Babiker A., Singer J., Cameron W., Schechter M., Brown S., Holodniy M., Youle M., Gazzard B. and the OPTIMA Team. An open-label randomized clinical trial of novel therapeutic strategies for HIV-infected patients in whom antiretroviral therapy has failed: rationale and design of the OPTIMA trial. Controlled Clinical Trials 2003; 24(4):481-500.
- Kyriakides TC., Eleftheriou A.,Michaelides N., Gogaki Z., Hadjianastasiou C., and Papantoniou L. 2002. Surveillance of Human Immunodeficiency Virus in the Army of the Republic of Cyprus (SHARC). Rationale, Design and Implementation of an Inexpensive System. Sexually Transmitted Infections 2002; 78(1): 50-52
- Kyriakides TC., and Heimer RH. 2001. Development and Application of a Genotypic AZT Resistance Assay. Quantitative Assessment of the Resistance Profile of Clinical Samples and the Relative Predictive Ability of a Resistance Index. JAIDS 2001; 28(3): 211-20
