Steven H Kleinstein PhD
Associate Professor of Pathology and of Immunobiology
Dr. Steven Kleinstein received a B.A.S. in Computer Science from the University of Pennsylvania and a Ph.D. in Computer Science from Princeton University. He is currently an Associate Professor of Pathology and Immunobiology at the Yale School of Medicine, and a member of the Interdepartmental Program in Computational Biology and Bioinformatics, and the Human Translational Immunology Program. While formally trained in Computer Science, Dr. Kleinstein has been working on applications in immunology for nearly 20 years. His research combines techniques from dynamic modeling, systems biology and bioinformatics to capitalize on recent advances in immune profiling methods to characterize diverse states of the human immune system (in health and disease, and following infection and vaccination). B cell adaptive immunity and somatic hypermutation have been a particular focus of his work. Recently, his lab has been developing computational methods for the processing and analysis of large-scale B cell immunoglobulin sequencing data sets generated by next-generation sequencing technologies. Another significant research focus involves the human immune response to influenza infection and vaccination.
Education & Training
- Princeton University (2002)