Scott A Strobel PhD

Vice President; Howard Hughes Medical Institute Professor; Henry Ford II Professor

Biographical Info

Professor Strobel's laboratory investigates the structural and mechanistic basis of RNA enzymes, with particular attention to two systems: self-splicing introns and peptide bond formation by the ribosome. The overriding question being addressed is: How does RNA, which is composed of building blocks best suited for a role in the storage of genetic information, catalyze biologically essential chemical reactions? To explore this question, they use chemical, biochemical, and biophysical methods ranging from organic synthesis to X-ray crystallography. These complementary approaches provide high-resolution biochemical and structural information about the RNAs under investigation. Their results have revealed that RNA uses catalytic strategies that are strikingly similar to those of proteins, the more adept and more common catalyst within cells. This includes catalysis promoted by active-site metal ions and substrate-assisted catalysis involving chemical groups on the reaction substrates.

International Activity

  • Ribosome Collaborations
    Professor Strobel's laboratory performed the synthesis of ribosomal substrate analogues. He and Professor Rodnina of Universitat Witten use these substrates in kinetic assays to characterize the chemical mechanism of the ribosome.

Education & Training

Postdoctoral Fellow
University of Colorado, Boulder, CO, Chemistry & Biochemistry (1992 - 1995)

Honors & Recognition

  • Beckman Young Investigator Award
    Arnold and Mabel Beckman Foundation (1997)
  • Professor
    Howard Hughes Medical Institute (2006)
  • Dylan Hixon Prize for Teaching Excellence in the Natural Sciences
    Yale University (2004)
  • Searle Scholar Award
    Searle Foundation (1997)
  • Graduate Mentoring Award
    Yale University (2007)
  • Beginning Investigator Award
    American Cancer Society (2002)
  • Schering Plough Research Institute Award
    American Society of Biochemistry and Molecular Biology (2008)

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