Ronald Stanton Duman, PhD

Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Neurobiology; Director, Abraham Ribicoff Research Facilities

Research Organizations

Interdepartmental Neuroscience Program

Neuroscience Microarray Center, Yale

NIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders

Psychiatry: Connecticut Mental Health Center | Molecular Psychiatry, Division of | Stress & Addiction Clinical Research Program | VA National Center for PTSD | VA-Yale Clinical Neurosciences PTSD Research Program

Research Summary

Studies in Dr. Duman's laboratory are focused on identifying the molecular and cellular adaptations that underlie the actions of antidepressant drugs and stress. This includes adaptations of receptors, signal transduction proteins, gene transcription factors, neurotrophic factors, and regulation of synaptic processes and even birth of new neurons (neurogenesis) in the adult brain. Preclinical and clinical studies support the hypothesis that neuronal atrophy and cell loss in response to stress contribute to mood disorders. Conversely, the therapeutic action of antidepressants may occur in part via blocking or reversing these damaging effects of stress. A variety of molecular approaches combined with cellular and behavioral studies are conducted to elucidate the basis of complex behavioral abnormalities.

Selected Publications

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Contact Info

Ronald Stanton Duman, PhD
Mailing Address
Department of Psychiatry34 Park Street
New Haven, CT 06508

Curriculum Vitae