Robert Walter Makuch, PhD

Professor of Public Health (Biostatistics) and in the Child Study Center; Director, Regulatory Affairs Track

Research Interests

Infant, Premature; Public Health; Smoking Cessation; Clinical Trials, Phase IV as Topic; Biostatistics

Research Organizations

School of Public Health: Global Health Concentration

Center for Nicotine and Tobacco Use Research at Yale (CENTURY)

Office of Cooperative Research

Research Summary

Professor Makuch's primary research interests involve methodologic issues in the design, conduct, and analysis of clinical studies. One area of particular interest is the appropriate design and analysis of active control equivalence studies, where he described in a series of papers how controls should be selected, how the sample size for these studies is determined, and what constitute appropriate methods of analysis. Design and sample size considerations for Phase IV studies is another active research area, in which a new class of hybrid designs has been proposed for scientific and regulatory purposes. Analytic areas of interest include prospective individual matching designs and methods for the analysis of longitudinal data. These methodological developments have been directed towards cancer and HIV. Dr. Makuch is currently developing a Biostatistics post-graduate program in Japan.

Specialized Terms: Clinical studies; Methodology

Extensive Research Description

  • Genetic and Brain Image Analysis of Premature Infants
  • Clinical Studies of Methods to Stop/Prevent Smoking
  • Biostatistical Design and Analysis Issues for Detection of Rare Adverse Events

Selected Publications

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Contact Info

Robert Walter Makuch, PhD
Office Location
Laboratory of Epidemiology and Public Health
60 College Street, Ste 203

New Haven, CT 06510
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Mailing Address
Yale School of Public HealthPO Box 208034
60 College Street

New Haven, CT 06520-8034

Curriculum Vitae