Richard Allan Ehrenkranz, MD

Professor of Pediatrics (Neonatology) and of Obstetrics, Gynecology, and Reproductive Sciences

Research Interests

Research Organizations

Pediatrics: Neonatal-Perinatal Medicine

Research Summary

My research interests include the nutritional requirements of very low birth weight (VLBW, birth weight

I coordinated Yale's participation in a multicenter research network of newborn intensive care units sponsored by the National Institute of Child Health and Human Development from 1991-2011. The purpose of this network was to design and perform collaborative clinical research investigations, both randomized clinical trials and observational studies. Examples of on-going or recently completed randomized clinical trials include projects evaluating the efficacy of parenteral glutamine supplementation in reducing the incidence of death or late-onset infection in extremely low birth weight infants, the efficiacy of induced hypothermia (body cooling) for hypoxic-ischemic encephalopathy in term infants, the efficacy of early erythropoietin therapy in reducing blood transfusions in infants <_3d_ 1250="" gm="" _birthweight2c_="" the="" efficacy="" of="" supplemental="" vitamin="" a="" therapy="" in="" prevention="" _cld2c_="" and="" dexamethasone="" treatment="" randomized="" trial="" aggressive="" vs="" conservative="" phototherapy="" extremely="" low="" birth="" weight="" infants="" _28_bw=""><_20_100020_gm29_2c_20_and20_the20_support20_trial20_that20_compared20_ventilation20_strategies20_and20_oxygenation20_target20_ranges20_beginning20_in20_the20_delivery20_room. 1000="" _gm29_2c_="" and="" the="" support="" trial="" that="" compared="" ventilation="" strategies="" oxygenation="" target="" ranges="" beginning="" in="" delivery="">

Extensive Research Description

My research interests include the nutritional requirements of very low birthweight (VLBW, birthweight

I also coordinate Yale's participation in a multicenter research network of newborn intensive care units sponsored by the National Institute of Child Health and Human Development. The purpose of this network is to design and perform collaborative clinical research investigations, both randomized clinical trials and observational studies.

Examples of on-going or recently completed randomized clinical trials include projects evaluating the efficacy of parenteral glutamine supplementation in reducing the incidence of death or late-onset infection in extremely low birth weight infants, the benefit of early vs. late inhaled nitric oxide therapy in the treatment of severe respiratory failure in term and near-term infants, the efficiacy of induced hypothermia (body cooling) for hypoxic-ischemic encephalopathy in term infants, the efficacy of early erythropoietin therapy in reducing blood transfusions in infants <_3d_ 1250="" gm="" _birthweight2c_="" the="" efficacy="" of="" supplemental="" vitamin="" a="" therapy="" in="" prevention="" _cld2c_="" and="" dexamethasone="" treatment="" randomized="" trial="" aggressive="" vs="" conservative="" phototherapy="" extremely="" low="" birth="" weight="" infants="" _28_bw="">

Examples of recently completed observational studies include the development of growth curves for VLBW infants and the validation of scales to assess gestational age and severity of illness in VLBW infants.

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain Disorders (ELGAN-2 Study)

This multicenter, neuroepidemiologic study is designed to test the hypothesis that children with elevated concentrations of inflammation-associated biomarkers in the blood in the highest quartile during the first 2 postnatal weeks, as compared to those without such elevations, have general cognitive ability deficits at 9 years. Study participants were enrolled in the ELGAN-1 Study and were all seen for neurodevelopmental follow-up at about 24 months corrected age.

Selected Publications

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Contact Info

Richard Allan Ehrenkranz, MD
Patient Care Locations
Yale NeonatalogyYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion, 2nd Floor

New Haven, CT 06504
Yale Pediatrics – NICU GRAD 1 Long Wharf Drive, Ste 2nd Floor
New Haven, CT 06511
Office Location
Yale-New Haven Hospital
20 York Street, Ste CH/WP 493

New Haven, CT 06510
Mailing Address
Yale Pediatrics333 Cedar ST
PO Box 208064

New Haven, CT 06520-8064

Curriculum Vitae