Peter S. Marshall MD, MPH

Assistant Professor of Medicine (Pulmonary); Medical Director, Medical Step-Down Unit YSC Yale-New Haven Hospital; Medical Director, Respiratory Care - Yale-New Haven Hospital

Research Interests

Risk stratification of patients with pulmonary embolism; Major pulmonary embolism treatment; Therapeutic hypothermia; Status asthmaticus

Current Projects

- Site Primary Investigator for the multi-center SEATTLE II Trial (Use of ultrasound accelerated throbolysis in the management of major pulmonary embolus). This project seeks to determine the safety and efficacy of ultrasound accelerated fibrinolysis in patients with life threatening pulmonary embolism.

- Site Primary Investigatory for "Retrievable Inferior Vena Caval Filters in Acute Pulmonary Embolism" multicetenter trial. This proposed study aims to determine the utility of retrievable filters in patients with varying severities of pulmonary embolism.

- Site Primary Investigator for the Venous Thromboembolism Prophylaxis Performance Improvement Project (VTE-PPIP) sponsored by the American College of Chest Physicians. This multi-center quality improvement project is designed to test an educational tool developed by the ACCP to improve compliance with DVT prophylaxis.

- Member of MICU biorepository. I am particularly interested in banking samples of patients managed with therapeutic hypothermia in hopes of identifying markers for prognosis and defining parameters for the application of therapeutic hypothermia.

Research Summary

Pulmonary embolism occurs when a clot blocks an artery that takes blood from the right side of the heart to the lungs. The condition is potentially life threatening. Finding methods to identify patients at greatest risk of harm (i.e. risk stratifying) from pulmonary embolism is important. Identifying patients at risk for harm allows us to offer aggressive interventions that may save lives.

Therapeutic hypothermia is the intentional cooling of patients for the purpose of improving outcomes. It is used in a variety of illnesses (most notably after cardiac arrest). The procedure is complex and has potential complications. Research into methods of improving methodology and minimizing complications is vital. This research may improve outcomes for patients treated with this intervention.

ICU patients are among the sickest in the hospital. They often have a long and complex hospital course. Studying the process and outcomes of these patients provides incites into the care they receive. Outcomes of interest include mortality, morbidity, length of stay and infections. Once information is gathered regarding the process and outcomes, interventions can be studied with the aims of improving outcomes for ICU patients in general.

Selected Publications

  • Marshall PS, Kerr KM, Auger WR; Chronic Thromboembolic Pulmonary Hypertension; Clinics in Chest Medicine; 34(4), December 2013
  • Marshall PS, Mathews K, Siegel MD; Management of Life Threatening Pulmonary Embolus; Journal of Intensive Care Medicine; 26(5) September/October 2011.
  • Marshall PS, Cain H; Upper Extremity Deep Vein Thrombosis; Clinics in Chest Medicine; 31(4), December 2010.
  • Marshall PS, Johnson K, Monteiro B, Siegel M Computed Tomography Can Predict Adverse Outcomes in Patients Presenting with Pulmonary Embolism Original research abstract presented at Chest 2005, November 1st, 2005.
  • Angelo SJ, Marshall PS et al Clinical Characteristics Associated with Poor Outcome in Patients Acutely Infected with Influenza A Connecticut Medicine 64(4): 199 – 205, April 2004.
  • Marshall PS, Possick J, Chupp G; ICU Management of Status Asthmaticus; Clinical Pulmonary Medicine 16(6), November 2009.
  • Marshall PS, Siegel MD; Therapeutic Hypothermia; PCCU Volume 23, Lesson 22, 2009 ( 22/index.php)
  • Marotta S, Belchikov Y, Banker K, Marshall PS; Emergency Management of Acute Severe Asthma Exacerbation in the Adult Population; Journal Of Asthma and Allergy Educators, October 2010.

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