Perry L Miller PhD, MD

Professor of Anesthesiology (Medical Informatics)

Research Interests

Biomedical informatics; Clinical informatics; Bioinformatics; Neuroinformatics


Research Summary

I am Director of the Yale Center for Medical Informatics (YCMI) and of the School of Medicine’s research training program in Biomedical Informatics, which is supported by the National Library of Medicine. Biomedical Informatics, a field at the intersection of biomedicine and the computing and information sciences, focuses on the creative use of computers in clinical medicine, biomedical research, and medical education. Research at the YCMI includes major projects in clinical, neuro-, and genome informatics. Current projects include

  1. Working with Prof. Gordon Shepherd (Neuroscience) on several neuroinformatics project, including the Yale SenseLab project and the national Neuroscience Information Framework (NIF) initiative;
  2. Working with several groups to develop University-wide informatics support for microarray research, mass-spectrometry proteomics research, and high throughput sequencing research;
  3. Developing databases and tools used by the laboratory of Prof. Kenneth Kidd (Genetics); and
  4. A growing number of clinical and genomic research projects based at the West Haven VA Medical Center.

Additional information is available at our web site.

Extensive Research Description

I am Director of the Yale Center for Medical Informatics (YCMI) and of the School of Medicine’s research training program in Biomedical Informatics, which is supported by the National Library of Medicine. Biomedical Informatics, a field at the intersection of biomedicine and the computing and information sciences, focuses on the creative use of computers in clinical medicine, biomedical research, and medical education. Research at the YCMI includes major projects in clinical, neuro-, and genome informatics. Current projects include 1) working with Prof. Gordon Shepherd (Neuroscience) on several neuroinformatics project, including the Yale SenseLab project and the national Neuroscience Information Framework (NIF) initiative; 2) working with several groups to develop University-wide informatics support for microarray research, mass-spectrometry proteomics research, and high throughput sequencing research; 3) developing databases and tools used by the laboratory of Prof. Kenneth Kidd (Genetics); and 4) a growing number of clinical and genomic research projects based at the West Haven VA Medical Center. Additional information is available at our web site.


Selected Publications

  • Marenco L, Li Y, Martone ME, Sternberg PW, Shepherd GM, Miller PL: Issues in the design of a pilot concept-based query interface for the Neuroinformatics Information Framework. Neuroinformatics 6(3):229-239, 2008.
  • Shifman MA. Li Y, Colangelo CM, Stone KL, Wu TL, Cheung KH, Miller PL, Williams KR: YPED: A Web-accessible database system for protein expression analysis. Journal of Proteome Research 6:4019-24, 2007.
  • Rozowsky J, Newburger D, Sayward F, Wu J, Jordan G, Korbel JO, Nagalakshmi U, Yang J, Zheng D, Guigo R, Gingeras T, Weissman S, Miller P, Snyder M, Gerstein M: The DART classification of unannotated transcription within the ENCODE regions: associating transcription with known and novel loci. Genome Research 2007 Jun;17(6):732-45.
  • Corwin J, Silberschatz A, Miller PL, Marenco L: Dynamic tables: An architecture for managing evolving, heterogeneous biomedical data in relational database management systems. Journal of the American Medical Informatics Association 14:86-93, 2007.
  • Dinu V, Miller PL, Zhao H: Evidence for association between multiple complement pathway genes and AMD. Genet Epidemiol 31:224-37, 2007.
  • Gerstein M, Greenbaum D, Cheung K, Miller PL: An interdepartmental Ph.D. program in Computational Biology and Bioinformatics: The Yale perspective. Journal of Biomedical Informatics 40:73-9, 2007.
  • Friedman CP, Altman RB, Kohane IS, McCormick KA, Miller PL, Ozbolt JG, Shortliffe EH, Stormo GD, Szczepaniak MC, Tuck D, and Jeffrey Williamson J: Training the next generation of informaticians: The impact of "BISTI" and bioinformatics—A report from the American College of Medical Informatics. Journal of the American Medical Informatics Association 11:167-172, 2004.
  • Miller PL, Nadkarni P, Singer M, Marenco L, Hines M, Shepherd G: Integration of multidisciplinary sensory data: a pilot model of the human brain project approach. Journal of the American Medical Informatics Association 8:34-48, 2001.
  • Miller PL: Tools for immunization guideline knowledge maintenance I: Automated generation of the logic “kernel” for immunization forecasting. Computers and Biomedical Research 31:172-189, 1998.
  • Miller PL, Frawley SJ, Brandt C, Sayward FG: Tools for immunization guideline knowledge maintenance II: Automated Web-based generation of user-customized test cases. Computers and Biomedical Research 31:190-208, 1998.

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