Oscar Rene Colegio MD, PhD
Assistant Professor of Dermatology
Squamous cell carcinoma; basal cell carcinoma; melanoma; tumor-associated macrophages; immunology; hypoxia; epithelial-mesenchymal transitions; solid organ transplantation
- The role of macrophages in progression of cutaneous squamous cell carcinomas
The focus of our lab is to characterize
the role of immune cells called macrophages in tumor progression. The
focus of these studies has been to identify pathways of tumorigenesis critical
to a variety of murine tumor types including lung carcinoma, melanoma, colon
carcinoma and cutaneous squamous cell carcinoma. In addition, we are performing parallel studies in identifying
tumor-promoting pathways produced by infiltrating macrophages in human squamous
cell carcinomas from immunosuppressed transplant recipients vs non-immunosuppressed patients.
- Liu LS, Colegio OR. Molecularly targeted therapies for nonmelanoma skin cancers. Int J Dermatol. 2013 Jun;52(6):654-65. doi: 10.1111/ijd.12017.
- Liu LS, Colegio OR. Molecularly targeted therapies for melanoma. Int J Dermatol. 2013 May;52(5):523-30. doi: 10.1111/j.1365-4632.2012.05829.x.
- Bangash HK, Colegio OR. Management of Non-Melanoma Skin Cancer in Immunocompromised Solid Organ Transplant Recipients. Curr Treat Options Oncol. 2012 May 17. [Epub ahead of print].
- Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25;484(7395):510-3.
- Colegio OR, Billingsley EM. Skin cancer in transplant recipients, out of the woods. Scientific retreat of the ITSCC and SCOPE. Am J Transplant. 2011 Aug;11(8):1584-91.
- Colegio OR, Kluger MS. Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by cutaneous squamous cell carcinoma? J Invest Dermatol. 2011 Jan;131(1):17-9.
- Colegio OR, Proby CM, Bordeaux JS, McGregor JM. Prognosis of pretransplant melanoma. Am J Tranplant. 2009 Apr;9(4):862.
- Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome
in the immunostimulatory properties of aluminum adjuvants. Nature. Published online May 21, 2008.
- Colegio OR, Van Itallie CM, Rahner C, Anderson JM. Extracellular domains of claudins determine paracellular
charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 2003 Jun
- Colegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol 2002 Jul; 283(1):C142-C147.