Nigel D. F. Grindley PhD

Professor Emeritus of and Senior Research Scientist in Molecular Biophysics and Biochemistry

Departments & Organizations

Molecular Biophysics and Biochemistry: DNA Replication and Repair

Research Interests

Serine recombinases; site specific recombination; mechanisms of protein-DNA transactions; DNA polymerases more...


  • Ph.D., London University, 1974

Selected Publications

  • Bai, H., Sun, M., Ghosh, P., Hatfull, G.F., Grindley, N.D.F. and Marko, J.F. (2011) Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase Proc. Nat. Acad. Sci. USA; published ahead of print April 18, 2011
  • Bermek, O., Grindley, N.D.F. and Joyce, C.M. (2011) Distinct roles of the active site Mg2+ ligands, D882 and D705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. J. Biol. Chem. 286, 3755-66 [E. pub. Nov. 16, 2010]
  • Santoso, Y., Joyce, C.M., Potapova, O., Le Reste, L.,Hohlbein, J., Torella, J.P., Grindley, N.D.F. and Kapanidis, A.N. (2010) Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Proc. Nat. Acad. Sci. USA 107, 715-20



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