Magnetic Resonance Imaging; Neurosciences; Obsessive-Compulsive Disorder; Stress Disorders, Post-Traumatic; Video Games; Neurofeedback; Psychiatry and Psychology
My lab is focused on the development and application of new functional brain imaging paradigms. These include resting state functional connectivity analyses and neurofeedback via real-time fMRI (rt-fMRI). Rt-fMRI neurofeedback has great potential as a clinical treatment for mental and neurological disorders. When used in conjunction with resting state functional connectivity assessments (collected before and after the neurofeedback), it provides a powerful perturb-and-measure approach for studying human brain function.
Extensive Research Description
1. We use neurofeedback of real-time fMRI data to train patients with tic disorders, OCD, and PTSD to control clinically relevant brain activity patterns. An important question is whether this training can improve their symptoms.
2. We evaluate changes in resting state functional connectivity between brain areas before and after neurofeedback. This allows us to investigate how neurofeedback alters brain networks. Also, by correlating changes in brain connectivity with symptom changes, we can gain insight into the neural circuitry that gives rise to symptoms.
3. We are examining the correlates of video game playing in adolescents. Fast-paced game players, slow-paced game players, and non-gamers are compared in terms of their brain function (assessed using resting state functional connectivity measures) and their behavior.
- Scheinost, D., Stoica, T., Wasylink, S., Saksa, J., Pittenger, C., Hampson, M. 2014. Resting state functional connectivity predicts neurofeedback response. Frontiers in Behavioral Neuroscience, 8: 338.
- Scheinost, D., Stoica, T., Saksa, J., Papademetris, X., Constable, R.T., Pittenger, C., Hampson, M. 2013. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry, 3, e250.
- Hampson, M., Driesen, N.R., Skudlarski, P., Gore, J.C., Constable, R.T. 2006. Brain connectivity related to working memory performance. The Journal of Neuroscience, 26(51): 13338-13343.
- Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. Hampson, M., Stoica, T., Saksa, J., Scheinost, D., Qiu, M., Bhawnani, J., Pittenger, C., Papademetris, X. 2011, Constable, R.T. (2011) Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety.
- Hampson, M., Scheinost, D., Qiu, M., Bhawnani, J., Lacadie, C., Leckman, J.F., Constable, R.T., Papademetris, X. 2011. Biofeedback from the supplementary motor area reduces functional connectivity to subcortical regions. Brain Connectivity, 1(1): 91-8.
- Hampson, M., Tokoglu, F., King, R.A., Constable, R.T., Leckman, J.F. 2009. Brain areas co-activating with motor cortex during chronic motor tics and intentional movements. Biological Psychiatry, 65(7): 594-9.
- Hoffman, R.E., Anderson, A.W., Varanko, M., Gore, J.C., Coric, V., Hampson, M. 2008. Time course of regional brain activation associated with onset of auditory/verbal hallucinations. British Journal of Psychiatry,193: 424-425.
- Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. Hampson, M., Tokoglu, F., Sun, Z. Schafer, R., Skudlarski, P., Gore, J.C., Constable, R.T., (2006) Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability.