Behavior and Behavior Mechanisms; Mental Disorders; Child Psychiatry; Nervous System Diseases; Neurobiology; Neurosciences; Nicotine; Pharmacology
Psychiatry: Center for Nicotine and Tobacco Use Research at Yale (CENTURY) | Connecticut Mental Health Center | Molecular Psychiatry, Division of | Neuroscience Research Training Program (NRTP) | Yale Tobacco Center of Regulatory Science | Yale Translational Center to Develop Gender-Sensitive Treatment for Tobacco Dependence
The goal of Dr. Picciotto's research team is to understand the role of single molecules in complex behaviors related to addiction, depression, feeding and learning. She and her colleagues use molecular genetic and pharmacological approaches to link the biochemical, cellular, and anatomical levels of investigation to behavior. Of primary interest is the role of nicotinic acetylcholine receptors in brain function and development.
Dr. Picciotto’s laboratory also studies signaling molecules downstream of nicotinic receptors, such as calcineurin, CaM kinases and adducins, which may mediate long-term changes in behavior downstream of these receptors.
Specialized Terms: Neuroscience; Molecular basis of behavior; Intracellular signaling; Mouse genetic models
Extensive Research Description
Our goal is to understand the role of single molecules in both typical behaviors and those related to psychiatric illness. We use molecular genetic and pharmacological approaches to link the biochemical, cellular, and anatomical levels of investigation to behavior. A primary focus is the role of nicotinic acetylcholine receptors in brain development and function.
We are also interested in signaling molecules downstream of nicotinic receptors that may mediate long-term changes in behavior following receptor activation. Ultimately, integration of studies at the molecular, cellular, and systems levels will be necessary to understand the neurobiological basis for expression and plasticity of complex behaviors.
- Developmental role of nicotinic acetylcholine receptors in cortico-thalamic circuits and related behavior
- Intracellular signaling pathways involved in the transition to behaviors related to nicotine addiction
- Nicotinic antagonists and partial agonists as novel antidepressants
- Circuits involved in nicotine's effects on feeding
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior
Jung, Y.-W., Hsieh, L.S., Lee, A.M., Zhou, Z., Coman, D., Heath, C.J., Hyder, F., Mineur, Y.S., Yuan, Q., Goldman, D., Bordey, A. and Picciotto, M.R. (2016) Nature Neuroscience, 19(7):905-14
Evaluation of the nicotinic acetylcholine receptor-associated proteome at baseline and following nicotine exposure in human and mouse cortext
McClure-Begley, T.D., Esterlis, I., Stone, K.L., Lam, T.T., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., Marks, M.J., Picciotto, M.R. (2016) eNeuro DOI: 10.1523/ENEURO.0166-16.2016
Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress
Mineur, Y.S., Fote, G.M., Blakeman, S., Cahuzac, E.L.M., Newbold, S.A. and Picciotto, M.R. (2016) Neuropsychopharmacology, 41(6):1579-87
Acetylcholine acts through nicotinic receptors to enhance the firing rate of a subset of hypocretin neurons in the mouse hypothalamus through distinct presynaptic and postsynaptic mechanisms
Zhou, WL, Gao, X.-B. and Picciotto, M.R. (2015) eNeuro, DOI: 10.1523/ENEURO.0052-14.2015
GABAergic and glutamatergic efferents of the mouse ventral tegmental area.
Taylor, S.R., Badurek, S., Dileone, R.J., Nashmi, R., Minichiello, L. and Picciotto, M.R. (2014) J Comp Neurol, 522(14):3308-34. PMC4107038