Lubna Pal MBBS, MRCOG (UK)

Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences; Director, Polycystic Ovary Syndrome (PCOS) Program; Director, Menopause Program

Research Interests

Decline in ovarian reserve and multisystem implications thereof; Polycystic Ovarian Syndrome (PCOS) and metabolic implications; Menopause; Vitamin D and Reproductive Function

Current Projects

1. Role of vitamin D in the pathophysiology of polycystic ovary syndrome (PCOS): Ongoing unblinded 3 month trial of vitamin D and Calcium supplementation to assess effects on glucose and insulin homeostasis.

2. Endometrial effects of Metformin in women with PCOS.


Research Summary

1. Ovarian reserve refers to the number of eggs available in the ovaries at any given age. While a decline in ovarian reserve with aging is clinically appreciable from mid 30's, as reflected by reduced likelihood to achieve pregnancy and increased risk of pregnancy losses, this process may be accelerated in some women. Our preliminary data sugest that declining ovarian reserve in premenopausal women is accompanied by deterioration in certain health parameters including the skeleton and surrogate markers for risk of cardiovascular disease.

2. Role of vitamin D insufficiency in reproductive physiology is suggested: Our preliminary data suggest that pregnancy rates following in vitro fertilization may be influenced by patient's vitamin D status.

3. Vitamin D insufficiency may be contributory to the pathophysiology of polycystic ovary syndrome. Ongoing clinical trial will hopefully clarify this hypothesis

Extensive Research Description

1. Ovarian reserve refers to the number of eggs available in the ovaries at any given age. While a decline in ovarian reserve with aging is clinically appreciable from mid 30's, as reflected by reduced likelihood to achieve pregnancy and increased risk of pregnancy losses, this process may be accelerated in some women. Our preliminary data sugest that declining ovarian reserve in premenopausal women is accompanied by deterioration in certain health parameters including the skeleton and surrogate markers for risk of cardiovascular disease.

2. Role of vitamin D insufficiency in reproductive physiology is suggested: Our preliminary data suggest that pregnancy rates following in vitro fertilization may be influenced by patient's vitamin D status.

3. Vitamin D insufficiency may be contributory to the pathophysiology of polycystic ovary syndrome. Ongoing clinical trial will hopefully clarify this hypothesis.


Selected Publications

  • Pal L, Zhang K, Zeitlian G, Santoro N. Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve.Fertil Steril. 2008 Dec 17. [Epub ahead of print]
  • Kummer N, Martin JR, Pal L.Diminished ovarian reserve in a woman with a balanced 13;21 translocation. Fertil Steril. 2009 Mar;91(3):931.e3-5. Epub 2008 Sep 30.

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