Lawrence J. Hirsch MD

Professor of Neurology; Chief, Division of Epilepsy and EEG; Co-Director, Yale Comprehensive Epilepsy Center; Co-Director, Critical Care EEG Monitoring Program

Research Interests

Epilepsy; Antiepileptic medication; Brain stimulation for epilepsy; Epilepsy surgery; Sudden death in epilepsy (SUDEP); Status epilepticus; ICU EEG monitoring; Critical care brain monitoring; Video-EEG monitoring; Intracranial EEG; Electrocorticography


Research Summary

Dr. Hirsch's interests and publications are on topics including brain monitoring in the critically ill, status epilepticus, epilepsy surgery, effectiveness and tolerability of antiepileptic drugs, brain stimulation for epilepsy, and sudden death in epilepsy.


Selected Publications

  • Gaspard N, Manganas L, Rampal N, Petroff OA, Hirsch LJ. Similarity of Lateralized Rhythmic Delta Activity to Periodic Lateralized Epileptiform Discharges in Critically Ill Patients. JAMA Neurol 2013 Aug 5. Epub ahead of print.
  • Hirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, Mani R, Arif H, Jette N, Minazad Y, Kerrigan JF, Vespa P, Hantus S, Claassen J, Young GB, So E, Kaplan PW, Nuwer MR, Fountain NB, Drislane FW. American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology: 2012 version. http://acns.org/ and J Clin Neurophysiol 2013;30(1):1-27.
  • Hirsch LJ. Intramuscular versus intravenous benzodiazepines for prehospital treatment of status epilepticus. N Engl J Med 2012; 366(7):659-60.
  • Foreman B, Claassen J, Abou Khaled K, Jirsch J, Alschuler DM, Wittman J, Emerson RG, Hirsch LJ. Generalized periodic discharges in the critically ill: a case control study of 200 patients. Neurology 2012;79(19):1951-1960.
  • Hirsch LJ, Donner EJ, So EL, Jacobs MP, Nashef L, Noebels JL, Buchhalter JR. Abbreviated Report of the NIH/NINDS workshop on Sudden Unexpected Death in Epilepsy (SUDEP). Neurology 2011;76(22):1932-8.

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