Julie Elizabeth Goodwin, MD

Assistant Professor of Pediatrics (Nephrology)

Research Interests

Glucocorticoids; Hypertension; Nephrology; Nephrotic Syndrome; Pediatrics; Steroids; Sepsis; Atherosclerosis

Research Organizations

Pediatrics: Pediatric Nephrology

Research Summary

The glucocorticoid receptor is found in nearly every cell type. It is the receptor for the body's endogenous steroid (cortisol) as well as for the many synthetic steroids (prednisone, dexamethasone) that are used therapeutically for a variety of conditions. Studies have clearly shown that this receptor has tissue-specific functions and that loss of the receptor in specific tissuess produces profound and unexpected phenotypes. I am interested in determining the role of this receptor in the endothelium, and more recently, in podocytes, the specialized cells which maintain the filtration barrier in the kdiney.

Specialized Terms: Glucocorticoid-induced hypertension; Vascular endothelial glucocorticoid receptor; Steroids and sepsis; Atherosclerosis; Podocyte glucocorticoid receptor and nephrotic syndrome

Extensive Research Description

  • Characterization and mechanism of glucocorticoid-induced hypertension in several mouse models with tissue-specific knockout of the glucocorticoid receptor
  • Effect of the knockout of the glucocorticoid receptor in the endothelium in a mouse model of LPS-induced sepsis, with and without steroid treatment
  • Role of the endothelial glucocorticoid receptor in the development of atherosclerosis
  • Role of the podocyte glucocorticoid receptor in the development of nephrotic syndrome

Selected Publications

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Contact Info

Julie Elizabeth Goodwin, MD
Patient Care Location
Yale Pediatric NephrologyYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor

New Haven, CT 06504
Lab Location
Sessa LabAmistad Street Building
10 Amistad Street, Ste 424

New Haven, CT 06519
Mailing Address
PO Box 208064
New Haven, CT 06520-8064