Jonathan Meiss Siner MD
Assistant Professor of Medicine (Pulmonary); Medical Director - Medical Intensive Care Unit, Yale-New Haven Hospital
Vascular Growth Factors; Sepsis pathophysiology; Host Response to Viral Infections
Dr. Siner currently conducts translational research examining the role of circulating growth factors in the sepsis syndrome and their relationship to outcomes in the intensive care unit. Patients with a diagnosis of sepsis are enrolled from the Medical Care Intensive Care Unit at Yale-New Haven Hospital. Plasma and DNA specimens are obtained and extensive clinical data is abstracted and entered into a clinical database. These investigations drawn on the extensive basic science activity conducted in the Pulmonary Section and examine these discoveries in humans with sepsis and ARDS (supported by an award from the CTSA). He was the recipient of an NIH National Research Service Award (NRSA) which supported his investigation of the role of VEGF and HO-1 in cytoprotection from hyperoxia induced acute lung inury. He is a site co-investigator on several ongoing multi-center trials investigating novel treatments for Sepsis, ARDS and Interstitial Lung Disease.