Anatomy; Spine; Health Care
Dr. Grauer's laboratory performs multiple studies critically evaluating aspects of orthopedic and spine clinical practice.
- Current clinical research studies
- Multiple national database outcome studies
- Multiple cohort studies
- Current basic / translational science studies
- Current clinical trials
- Pfizer, “Phase 2B, randomized, double-blind, placebo-controlled, study to evaluate the safety and efficacy of staphylococcus aureus 4-antigen (SA4AG) vaccine in adults undergoing elective posterior instrumented lumbar spinal fusion procedures”, co-investigator.
- Spinal Kinetics, “Concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics™ M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic cervical radiculopathy”, co-investigator.
- Orthofix, “Safety and efficacy of pulsed electromagnetic fields (Cervical-Stim®) as an adjunct to enhance union in conservatively treated Type II fractures of the odontoid process”, co-investigator
- Current grants
- Multiple Yale University School of Medicine Medical Student research supports awards
Extensive Research Description
Dr. Grauer directs an active research group that focuses on clinical outcomes of spine and orthopaedic patients. In an era of striving to optimize patient outcomes, it is crucial that we learn from our patients to advance clinical care.
National databases track large numbers of patients and allow for the study of such outcomes. Dr. Grauer works closely with his student and resident team to draw clinically meaningful messages from large data sets. What patients will do best from an intervention? Which technique is best for which person? Who is at risk for an adverse event? These are just some of the questions being addressed.
As with any type of research, studies based on national databases have both advantages and limitations. Balancing the use of such databases, Dr. Grauer’s team works to delineate the limitation of national database work and strives to optimize studies based on their data. In doing so, they work to draw the most meaningful and valid conclusions possible.
In addition to the above-noted studies, Dr. Grauer’s team is active with studies looking at patients treated locally. With studies evaluating diagnostic imaging modalities, patient characteristics, and patient outcomes, they are able to study more detailed local data.
Overall, Dr. Grauer mentors many Yale medical students and fellows in performing research studies. The team has received multiple awards. He and his group have given over 250 research talks at national and international meetings, and co-authored over 150 peer-reviewed scientific papers.
Three-Dimensional Isotropic MRI of the Cervical Spine: A Diagnostic Comparison With Conventional MRI.
Fu MC, Buerba RA, Neway WE 3rd, Brown JE, Trivedi M, Lischuk AW, Haims AH, Grauer JN. Clinical Spine Surgery 2016; 29: 66-71.
Incidence and Risk Factors for Pneumonia After Posterior Lumbar Fusion Procedures: An ACS-NSQIP Study.
Bohl DD, Mayo BC, Massel DH, Iantorno SE, Ahn J, Basques BA, Grauer JN, Singh K. Spine 2016; 41: 1058-1063.
How do Orthopaedic Devices Change After Their Initial FDA Premarket Approval?
Samuel AM, Rathi AM, Grauer JN, Ross JS. Clinical Orthopaedics and Related Research 2016; 474: 1053-1068.
Spinal Fracture in Patients With Ankylosing Spondylitis: Cohort Definition, Distribution of Injuries, and Hospital Outcomes.
Lukasiewicz AM, Bohl DD, Varthi AG, Basques BA, Webb ML, Samuel AM, Grauer JN. Spine 2016; 41: 191-196.
Nationwide Databases in Orthopaedic Surgery Research.
Bohl DD, Singh K, Grauer JN. Journal of the American Academy of Orthopedic Surgeons 2016; 24: 673-682.
Primary and Revision Posterior Lumbar Fusion Have Similar Short-Term Complication Rates.
Basques BA, Diaz-Collado PJ, Geddes BJ, Samuel AM, Lukasiewicz AM, Webb ML, Bohl DD, Ahn J, Singh K, Grauer JN. Spine 2016; E101-106.
Comparison of Agreement of Cervical Spine Degenerative Pathology Findings in Magnetic Resonance imaging studies.
Fu MC, Webb ML, Buerba RA, Neway WE, Brown JE, Trivedi M, Lischuk AW, Haims AH, Grauer JN. The Spine Journal 2016; 16: 42-48.
Factors Affecting Length of Stay and Complications After Elective Anterior Cervical Discectomy and fusion: A study of 2,164 patients from the American College of Surgeons National Surgical Quality Improvement Project Database (ACS NSQIP).
Gruskay JA, Fu M, Basques BA, Bohl DD, Buerba RA, Webb ML, Grauer JN. Clinical Spine Surgery 2016; 29: E34-E42.
How much do adverse event rates differ between primary and revision total joint arthroplasty?
Bohl DD, Samuel AM, Basques BA, Della Valle CJ, Levine BR, Grauer JN. Journal of Arthroplasty 2016; 31: 596-602.
A genetic test predicts Providence brace success for adolescent idiopathic scoliosis when failure is defined as progression to > 45 degrees.
Bohl DD, Telles CJ, Ruiz FK, Badrinath R, DeLuca PA, Grauer JN. Clinical Spine Surgery 2016; 29: E146-E150.
Preoperative nutritional status as an adjunct predictor of major postoperative complications following anterior cervical discectomy and fusion
Fu MC, Buerba RA, Grauer JN. Clinical Spine Surgery 2016; 29: 167-172.
Do we really know our patient population in database research? A comparison of the femoral shaft fracture patient populations in three commonly used national databases.
Samuel AM, Lukasiewicz AM, Webb ML, Bohl DD, Basques BA, Varthi AG, Leslie MP, Grauer JN. Bone Joint Journal 2016; 98-B: 425-432.
Incidence and risk factors for pneumonia following anterior cervical decompression and fusion procedures: an ACS-NSQIP study.
Bohl DD, Ahn J, Rossi VJ, Tabaraee E, Grauer JN, Singh K. The Spine Journal 2016; 16: 335-342.
Perioperative outcomes after cervical laminoplasty versus posterior decompression and fusion: Analysis of 779 patients in the ACS-NSQIP database.
Varthi AG, Basques BA, Bohl DD, Golinvaux N, Grauer JN. Clinical Spine Surgery 2016; 29: E226-E232
Variation in resource utilization for patients with hip and pelvic fractures despite equal Medicare reimbursement
Samuel AM, Webb ML, Lukasiewicz AM, Basques BA, Bohl DD, Varthi AG, Lane JM, Grauer JN. Clinical Orthopaedics and Research 2016; 474: 1486-1494.
Incidence and Risk Factors for Pneumonia following Anterior Cervical Decompression and Fusion Procedures: An ACS-NSQIP Study
Bohl DD, Ahn J, Rossi VJ, Tabaraee E, Grauer JN, Singh K. The Spine Journal 2016; 16:335-342
Most 30-day readmissions after anterior cervical discectomy and fusion are not due to surgical site-related issues: An analysis of 17,088 patients.
Samuel AM, Fu MC, Toy JO, Lukasiewicz AM, Webb ML, Bohl DD, Basques BA, Albert TJ, Grauer JN. Spine 2016; 41: 1801-1807.
Patient factors associated with 30-day morbidity, mortality, and length of stay after surgery for subdural hematoma: A study of the American College of Surgeons National Surgery Quality Improvement Program.
Lukasiewicz AM, Grant RA, Basques BA, Webb ML, Samuel AM, Grauer JN. Journal of Neurosurgery 2016; 124: 760-766.