John S Giuliano Jr MD

Assistant Professor of Pediatrics (Critical Care); Medical Director, Pediatric Transport Service; Associate Medical Director, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Service; Associate Medical Director, Pediatric Intensive Care Unit

Research Interests

Pediatric sepsis; Acute lung injury and the inflammatory response

Current Projects

• Describing the temporal kinetics of angiopoietin levels in children with varying degrees of sepsis.
• Implementing a transport risk assessment in pediatrics (TRAP) scoring system to help triage children safely when transported from outside institutions.

Research Summary

John Giuliano, M.D, has focused his research interests around inflammation and the host’s response to sepsis/acute lung injury. To this end, he is involved in a translational research project looking at the role angiopoietins play in capillary leak from pediatric sepsis. Additionally, he is looking at the incidence of morbidity and mortality in pediatric patients admitted to the ICU with the novel H1N1 influenza A virus. He is also evaluating appropriate levels of sedation in mechanically ventilated children and neonates using an EEG tool. Finally, he is investigating the use of an objective pediatric transport scoring system to aid in transported patient triage and transport team composition

Extensive Research Description

Giuliano Jr. JS, Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR, Wheeler DS. Plasma Angiopoietin-2 Levels Increase in Children Following Cardiopulmonary Bypass. Intensive Care Med 2008; 34(10):1851-7

Abboud PA, Lahni PM, Page K, Giuliano Jr. JS, Harmon K, Dunsmore KE, Wong HR, Wheeler DS. The Role of Endogenously Produced Extracellular Heat Shock Protein 72 in Mononuclear Cell Reprogramming. Shock 2008; 30(3):285-92

Giuliano Jr. JS, Lahni PM, Wong HR, Carcillo JA, Sukhatme VA, Parikh SM, Wheeler DS. Admission Angiopoietin Levels in Children with Septic Shock. Shock 2007;28(6):650-654

Weiderholt K, Sharanabasava BR, Giuliano Jr. JS, O’Donnell MJ, and McLaughlin LW. DNA-Tethered Hoechst Groove-Binding Agents: Duplex Stabilization and Fluorescence Characteristics. J Am Chem Soc 1996;118:7055-7062