João P. Pereira PhD

Assistant Professor of Immunobiology

Research Interests

Immunology; Hematopoiesis; B-lymphocyte development; Bone marrow niches; Cell migration

Research Summary

Research in this laboratory is focused on several aspects related to hematopoiesis, a fundamental and complex cell differentiation process that generates many different cell types including all blood cells. With the exception of T-lymphocytes, all other hematopoietic cells are predominantly generated in the bone marrow of adult mammals. Central to this process are the bone marrow niches where immune cells develop. These are sites where hematopoietic precursors travel to meet with specialized bone marrow stromal cells that provide lineage-specific signals necessary for their development and differentiation. Our laboratory is specifically interested in understanding the molecular mechanisms that regulate hematopoietic cell development, positioning and migration within bone marrow niches, and export into the periphery under normal homeostatic conditions. Our long-term goals are to understand at the molecular level how these mechanisms are regulated during changes in the environment such as inflammation, hormone imbalance, hypoxia, etc.

Selected Publications

  • Beck TC, Gomes AC, Cyster JG, and Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014 Nov 17. pii: jem.20140457. [Epub ahead of print]
  • Pereira JP, Cyster JG, Xu Y. A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One. 2010 Feb 18;5(2):e9277.
  • Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature. 2009 Aug 27;460(7259):1122-6. Epub 2009 Jul 13.
  • Pereira JP, An J, Xu Y, Huang Y, Cyster JG. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol. 2009 Apr 10(4):403-11.
  • Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol. 2010 Jun;22(6):413-9.

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