Anemia, Sickle Cell; Blood Transfusion; Hematology; Immune Tolerance; Plasmapheresis; Pregnancy Complications, Hematologic; Immunity, Humoral
The Hendrickson laboratory primarily studies complications of transfusion therapy, including the development of immune responses to antigens expressed on transfused blood products. Millions of blood products are transfused annually, and immune responses to transfused red blood cells or platelets or white blood cells may complicate future transfusions, pregnancies, or organ transplantation. Factors influencing alloimmunization, including those on the donor and recipient sides of the equation, are studied in the Hendrickson laboratory. Environmental and genetic variables that impact the intersections of innate and adaptive immunity are also studied. Some studies involve reductionist models with expression of authentic human blood group antigens, whereas others are more translational/patient focused. In addition to developing strategies to prevent alloimmunization in a transfusion setting, the Hendrickson laboratory is also working to develop strategies to prevent alloimmunization or to mitigate the dangers of existing maternal alloantibodies in a pregnancy setting.
Extensive Research Description
Please pubmed search Hendrickson JE to see the range of topics the Hendrickson lab is interested in. In general, the lab is interested in investigating clinically relevant issues in transfusion medicine using basic science models and translational research tools.
- Hendrickson JE, Eisenbarth SC, Tormey CA. Curr Opin Hematol. 2016 Nov;23(6):543-549.
- Natarajan P, Liu J, Santhanakrishnan M, Gibb DR, Slater LM, Hendrickson JE. Transfusion. 2016 Oct 13. doi: 10.1111/trf.13864.
- Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Blood. 2016 Sep 29. pii: blood-2016-06-724732.
- Arneja A, Salazar JE, Jiang W, Hendrickson JE, Zimring JC, Luckey CJ. Haematologica. 2016 Aug 4. pii: haematol.2016.149278.