Janghoo Lim PhD
Assistant Professor of Genetics
Mechanisms of neural development; Neurological disorders; Neurodegenerative diseases
Pathogenesis studies of polyglutamine diseases
Neurological disorders affect millions of people worldwide, and health care costs related to treating these illnesses are enormous. They include a broad spectrum of brain problems such as birth defects, mental retardation, neuropsychiatric disorders, and neurodegenerative diseases.
The overall goal of my laboratory is to better understand the fundamental mechanisms of neural development and function, as well as its relevance to the pathogenesis of diverse human neurological disorders. The lab is focused on two major questions. First, how is neurogenesis regulated during embryonic and adult stages and how does its malfunction contribute to neurological problems? Second, what is the molecular and cellular basis of neurodegenerative diseases?
To achieve this goal, we utilize the combined approaches of biochemistry, cell biology, behavior, and molecular genetics with in vivo animal (e.g. Drosophila and mouse) models.