Irvin M Modlin MD, DSc, FRCS (Eng & Ed), FCS (SA)

Biographical Info

Dr Modlin is currently Professor of Gastroenterological Surgery at Yale University, School of Medicine and director of the GI Pathobiology Research Group. Dr. Modlin was born in Cape Town, South Africa and educated (sic) in Cape Town, Dublin, Leeds and London. He received a M.B, Ch B. magna summa cum laude and the Gold Medals for Surgery by both the South African College of Surgeons and the Royal College of Surgeons of Edinburgh in 1975. He trained in gastrointestinal surgery, advanced endoscopy and endocrine surgery at the Royal Postgraduate Medical School, Hammersmith Hosp, University of London (1975-1977) before joining the faculty at UCLA and the Center for Ulcer Research Education (1977-1979). In 1980 he joined the faculty at SUNY, New York and in 1984 was appointed Vice Chairman of the department of Surgery at Yale and Chief of Surgery at the West Haven Veterans Administration Medical Center. In 1989, the University of Cape Town awarded Dr. Modlin a Ph.D. in molecular physiology.

In 1990 he received a Fulbright scholarship (1989-1990) and in 1991 the University of Gothenburg in Sweden awarded him a M.D. (Hon. Causa). In 2005 he received a DSc. in gastroenterology for his work in the field of neuroendocrine biology. He has delivered the I.N. Marks lecture (Johannesburg, 1994), the Jena Polya Memorial Lecture (Budapest, 1995), the Arris and Gale lecture (London, 1995) and the Theodor Kocher Oration (Bern, 1996). In 1997, he was appointed Huntarian Professor by the Royal College of Surgeons of England and in 1998 received a fellowship. In 1999, he delivered the Bayliss and Starling Lecture at Queen’s University, Belfast and in 2000 the Centenary Oration at the Japanese Surgical Society. In 2002, the Royal College of Surgeons of Edinburgh appointed him a James IV Professor and in 2005 he received the Mikulicz medal of the Polish surgical society. He has received the Yale surgical teaching award on numerous occasions.

Dr Modlin’s current clinical interests are in neuro endocrine tumor disease therapy and esophagitis and his research focuses on the molecular basis of enterochromaffin cell function, neoplastic transformation and the mathematical modeling and identification of genetic signatures of metastasis. In 2007 he chaired the NCI Summit Conference on Neuroendocrine Tumor Disease in Washington DC and in 2008 the Neuroendocrine Tumor Pathology Consensus Summit. His investigative studies have been funded by the US Federal government and the National institutes of Health for more than two decades. Dr Modlin has been the distinguished guest and state of the art lecturer in over a hundred universities and medical schools in more than thirty countries. He has authored ~ 450 peer reviewed scientific and clinical papers and written ~16 books on subjects including Neuro endocrine tumor disease, Acid peptic disease, pancreatic maladies, laparoscopic surgery, GI endoscopy, the evolution of therapy, the history of medicine, the medical evolution of cities (Vienna, Rome, Birmingham, New Orleans, Washington, etc) and Dutch art. Currently his activities focus on therapeutic consensus development, the identification of viable advances in translational research as well as biotechnology interface assessment and application.


International Activity

  • Goeteborg
    Goeteborg, Sweden   (2003)
    Perr Dubb Oration
  • Presentation- “The Molecular Basis of the ECL cell,” Per Dubb Oration
    Goeteborg, Sweden   (2003)
    Presentation- “The Molecular Basis of the ECL cell,” Per Dubb Oration
  • Hamburg, Germany   (2003)
    Presentation- Current Status of GERD management, German Endoscopic society
  • London, United Kingdom   (2003)
    Presentation- “From the Macula to the Mucosa,” Royal Society of Medicine
  • Amsterdam, Netherlands   (2002)
    Invited speaker, “Cancer of Esophagus and Gastric Cardia: From Gene to Cure”
  • Amsterdam, Netherlands   (2002)
    Invited speaker, “Perspectives and reflections on integrated digestive surgery,” The Future of Gastro-Entero-Hepato-Pancreatology is Bright
  • Amsterdam, Netherlands   (2002)
    Invited speaker, “Amsterdam and Netherlands Gastroenterology: a historical perspective,” The Future of Gastro-Entero-Hepato Pancreatology is Bright
  • Japan   (2002)
    Invited speaker, “Stem cells and mucosal dynamics: Regulation, repair and neoplasia,” Japanese Society of Ulcer Research
  • India   (2002)
    Keynote address, Indian Hepatobiliary Society, “Surgery of chronic pancreatitis”
  • Edinburgh, United Kingdom   (2002)
    James IV Oration, “Molecular strategies and 111In-labeled somatostatin analogs in defining the management of neuroendocrine tumor disease: A new paradigm for surgical management”
  • Oman   (2002)
    Examiner, University of Oman, Department Surgery
  • India   (2002)
    Keynote address, Indian Hepatobiliary Society
  • Edinburgh, United Kingdom   (2002)
    James the IV Oration
  • Iceland   (2001)
    Gastric Carcinoid Molecular Biology, Nordic Endocrine Society Meeting
  • Heidelberg, Germany   (2001)
    Invited Speaker International Pancreatic Meeting
  • Heidelberg, Germany   (2001)
    Invited Speaker International Pancreatic Meeting
  • Germany   (2001)
    Invited Speaker, International Pancreatic Meeting, “The surgery of chronic pancreatitis—A chronicle of confusion and despair?”
  • Tokyo, Japan   (2000)
    Invited Speaker: “From k-Ras to Kagoshima,” 100-year Anniversary of the Japanese Surgical Society
  • New Haven, United States   (2000)
    Presentation- “Beyond Wittgenst," The Eastern Surgical Society:
  • Bern, Switzerland   (2000)
    Presentation- “The Evolution of Chronic Pancreatitis,” International Chronic Pancreatitis Symposium
  • Paris, France   (2000)
    Presentation- “The Molecular and Historic Basis of Barrett’s Esophagus," International Esophageal Meeting,
  • Presentation
    Bermuda   (2000)
    “From the Pump to the Helix,” International Helicobacter pylori Meeting
  • Heidelberg, Germany   (2000)
    Keynote address: Minimally Invasive Endoscopic Society
  • Hunterian Professorship
    London, United Kingdom   (1999)
    Hunterian Professorship
  • Invited Speaker
    Veldhoven, Netherlands   (1999)
    Invited Speaker, The Dutch Gastro Society, “The Golden Age of Dutch Medicine”
  • Belfast, United Kingdom   (1999)
    Invited Speaker, British Society of Surgery, “Carcinoid Biology and Surgery”
  • Royal College of Surgeons of England
    London, United Kingdom   (1998)
    Royal College of Surgeons of England
  • Bern, Switzerland   (1996)
    Invited Speaker, The Theodor Kocher Memorial Lecture
  • Shimoda, Japan   (1996)
    Invited Speaker, Molecular Biology of Wound Healing, Japanese Gastroenterology Society
  • Bangkok, Thailand   (1996)
    Invited Speaker, Strategies of GERD management
  • Bern, Switzerland   (1996)
    Invited Speaker, Gastroesophageal Reflux Disease: Back to Surgery?
  • Berlin, Germany   (1996)
    Invited Speaker, Consensus Workshop for Surgical Treatment of Neuroendocrine Gastroenteropancreatic Tumors
  • Cape Town, South Africa   (1995)
    Co-Organizer/Session Chairman, International Meeting, Current Research in Gastrointestinal Disease: The African Perspective
  • Budapest, Hungary   (1995)
    Invited Speaker, Polya Memorial Lecture
  • London, England, United Kingdom   (1995)
    Invited Speaker, The Arris and Gale Lecture, "The Pathophysiology of the Fundic Enterochromaffin- like (ECL) Cell and Gastric Carcinoid Tumors"
  • Bern, Switzerland   (1995)
    Session Chairman, International Meeting, Five Years of Laparoscopic Cholecystectomy: A Reappraisal
  • Messina, Italy   (1995)
    Invited Speaker, International Workshop on New Trends in the management of Pancreatic Disease, The Managment of Acute Pancreatitis- Who Are We Kidding?
  • Edinburgh, Scotland, United Kingdom   (1994)
    Invited Speaker, British Society of Gastroenterology Prout Club Meeting
  • Bern, Switzerland   (1994)
    Invited Speaker, International Meeting, Pancreatic Diseases, New Horizons - Chronic Pancreatitis: Pre-cancerous disease?
  • Sun City, South Africa   (1994)
    Invited Speaker, SAGES Congress - Solly Marks lecture: The new gastric creed of the third milennium
  • Paris, France   (1994)
    Invited Speaker, Reunion Annuelle Du GRESZE - Experimental models of ECLomas
  • Invited Speaker
    Munchsmunster, Germany   (1994)
    Invited Speaker, Carcinoid Tumors - International Symposium on Pathology, Epidemiology, Clinical Aspects and Therapy
  • London, United Kingdom   (1994)
    Prout Club, London
  • Invited Speaker
    Tuebingen, Germany   (1993)
    Invited Speaker, Tissue Repair-Wound Healing Mechanisms, Therapeutic Implications
  • Berlin, Germany   (1993)
    Invited Speaker, Molecular and Cell Biological Aspects of Gastroenteropancreatic Neuroendocrine Tumor Disease
  • London, United Kingdom   (1993)
    Visiting Professor
  • Dublin, Ireland   (1993)
    Visiting Professor
  • London, England, United Kingdom   (1993)
    Visiting Professor
  • Glasgow, United Kingdom   (1993)
    Visiting Professor
  • United Kingdom   (1993)
    Visiting Professor
  • United Kingdom   (1993)
    Visiting Professor
  • Antalya, Turkey   (1993)
    Invited Speaker, Molecular Mechanisms of Mucosal Healing
  • Royal Club, Current Perspectives in Acute Pancreatitis
    Evian-les-Bains, France   (1992)
    Royal Club, Current Perspectives in Acute Pancreatitis
  • Medical and Surgical Management of Carcinoid Tumors
    Padova, Italy   (1992)
    Medical and Surgical Management of Carcinoid Tumors
  • Israel Gastroenterology Association
    Eilat, Israel   (1992)
    Israel Gastroenterology Association
  • London, United Kingdom   (1992)
    Athenaeum Club, London
  • London, United Kingdom   (1991)
    European Acid Suppression Workshop
  • Sydney, Australia   (1990)
    World Conference on Gastroenterology, Pathophysiology of Acute Pancreatitis
  • Pancreatitis Symposium
    Marburg an der Lahn, Germany   (1990)
    Pancreatitis Symposium, Subcellular Activation of Pancreatic Enzyme
  •   (1990)
    Chairman, Surgical Section of the Advisory Board, International Gastro-Surgical Club
  • Berlin, Germany   (1990)
    Experimental Ulcer Conference
  • Swedish Endocrine Society
    Goeteborg, Sweden   (1990)
    Swedish Endocrine Society
  • Freiburg, Germany   (1990)
    Falk Symposium, TGF a Secretory Regulation of Parietal Cells
  • Lund, Sweden   (1990)
    Oncogene Amplification in Gastric ECLoma Tumors
  • Hong Kong, China   (1989)
    Pathobiology of Acute Pancreatitis
  • Bleeding in Portal Hypertension
    Taormina, Italy   (1989 - 1989)
    Presentation- Pathophysiology of Bleeding in Portal Hypertension
  • Surgery of Peptic Ulceration
    Rome, Italy   (1989 - 1989)
    Surgery of Peptic Ulceration
  • Mechanisms of ECL Cell Neoplasia
    Florence, Italy   (1989 - 1989)
    Mechanisms of ECL Cell Neoplasia
  • Umea, Sweden   (1989)
    Pathobiology of the Endocrine Stomach
  • Bern, Switzerland   (1989)
    Mechanisms of Intracellular Zymogen Activation
  • Cape Town, South Africa   (1989)
    Surgical Management of Pancreatitis
  • Rome, Italy   (1989)
    The ECL Quincunx
  • South Africa   (1989)
    Pathogenesis of Pancreatitis
  • Cape Town, South Africa   (1989)
    From Prout to the Proton Pump
  • The Adoration of the Vagi
    Goeteborg, Sweden   (1988)
    The Adoration of the Vagi
  • Sweden   (1988)
    Nordic Endocrine Society, Cholecystokinin Receptor Antagonists
  •   (1987)
    International Gastro-Surgical Club
  • Examiner
    Edinburgh, United Kingdom   (1985 - 2003)
  • Stockholm, Sweden   (1982)
    World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion
  • Stockholm, Sweden   (1982)
    World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion
  • Florence, Italy   (1981)
    World Gut Hormone Symposium: The Release of Pancreatic Polypeptide by Xenopsin
  • World Gut Hormone Symposium
    Cambridge, United Kingdom   (1980)
    Release of Substance P by a Meal
  • World Gut Hormone Symposium
    Cambridge, United Kingdom   (1980)
    Cholinomimetric Modulation of PP Release
  • World Gut Hormone Symposium
    Cambridge, United Kingdom   (1980)
    Intestinal Phase of PP Release
  • Royal Society of Medicine of England
    United Kingdom   (1980)
    Royal Society of Medicine of England
  •   (1980)
    International Association of Endocrine Surgeons
  •   (1980)
    International Society of Surgery
  • Norway   (1978)
    World Gut Hormone Symposium: Atropine Resistant CCK Like Peptide Release
  • Oslo, Norway   (1978)
    World Gut Hormone Symposium: Effect of Motilin on Gastric Emptying
  • United Kingdom   (1977)
    VIP, British Society of Gastroenterology, A New Component of the Autonomic Nervous System
  • United Kingdom   (1977)
    British Regional Hospital Pharmaceutical Course, Adrenal Surgery
  • United Kingdom   (1977)
    Royal Postgraduate Medical School surgical Course: Aspects of Colonic Angiodysplasia
  • United Kingdom   (1977)
    British Surgical Research Society: Mechanisms of Motilin Release
  • Warsaw, Poland   (1977)
    European Surgical Research Society: Motilin Release in the Pig
  • United Kingdom   (1976)
    Royal Society of Medicine: Haemorrhage in Reduplications of the Duodenum
  • United Kingdom   (1976)
    British Endocrine Society.: VIP Release in Intestinal Ischemia
  • United Kingdom   (1976)
    University of London Surgical Endocrinology Symposium: Phaechromocytoma Management.
  • United Kingdom   (1976)
    British Postgraduate Medical Federation Gastroenterology Course: Multi Hormone Secreting Gut Tumors
  • United Kingdom   (1976)
    University of London MSc Course in Clinical Biochemistry: APUDomas of the Gut
  • London, United Kingdom   (1976)
    Postgraduate Gastroenterology Teaching Course, St. Charles Hospital
  • Lausanne, Switzerland   (1976)
    International Gut Hormone Symposium: VIP Pharmacokinetics
  • United Kingdom   (1976)
    British Society of Gastroenterology: VIP and Diarrhea
  • Edinburgh, United Kingdom   (1975)
    Royal College of Surgeons of Edinburgh
  • South Africa   (1975)
    South African College of Surgeons
  • United Kingdom  
    Visiting Professor
  • London, United Kingdom  
    ECL Cell Symposium
  • Oman  
    External Surgical Assessor
  • Iceland  
    Presentation- “Gastric Carcinoid Molecular Biology,” Nordic Endocrine Society Meeting

Education & Training

M.D.
University of Capetown, South Africa (1968)
Intern
Groote Schuur Hospital, Cape Town, South Africa
Intern
Military Hospital, Pretoria, South Africa
Senior House Officer
St. James Hospital, London, England, Accident Unit 
Registrar
Groote Schuur Hospital, Trauma Unit 
Resident
Groote Schuur Hospital, Cape Town, South Africa, Surgery 
Chief Surgical Officer
Hammersmith Hospital, London, England
Senior Surgical Registrar
Hammersmith Hospital, London, England
Visiting Scientist
University of California, Los Angeles, Center for Ulcer Research and Education (CURE), Los Angeles, CA, Gastroenterology 
Fellow
University of London, Gastroenterology/Endocrine 

Honors & Recognition

  • Master of Arts, Honoris Causa
    Yale University, New Haven, CT (1987)
  • Doctor of Medicine, Honoris Causa
    Goteborg, Sweden (1991)
  • Grand Global Award” for craftsmanship
    A History of Gastroenterology at the Millennium (2001)
  • University of Cape Town Entrance Scholarship
    University of Cape Town, Cape Town, South Africa (1963)
  • University Medal For Physiology
    University of Cape Town, Cape Town, South Africa (1964)
  • University Medal For Medicine
    University of Cape Town, Cape Town, South Africa (1966)
  • University Medal For Chemical Pathology
    University of Cape Town, Cape Town, South Africa (1967)
  • South African Society of Anaesthetists Medal
    South African Society of Anaesthetists (1967)
  • Urology Prize
    (1967)
  • Aaron Behrman Scholarship For The Best Student of The Year
    (1967)
  • Dowie Dunn Memorial Prize For Paediatrics
    (1968)
  • University Medal For Surgery
    University of Cape Town, Cape Town (1968)
  • Stabler Prize The Best Graduating Student In Surgery
    (1968)
  • Valedictorian
    University of Cape Town Medical School, Cape Town, South Africa (1963-1968)
  • University Gold Medal-Most Distinguished Graduate In Medicine
    University of Cape Town, Cape Town, South Africa (1968)
  • The University of Cape Town Post-graduate Scholarship In Medicine
    University of Cape Town, Cape Town, South Africa (1968)
  • Degree Cum Laude and With Distinction In The Final Professional Examination
    University of Cape Town, Cape Town, South Africa (1968)
  • F.R.C.S. (Edinburgh) G.B. Ong Gold Medal - Most Distinguished Candidate
    (1975)
  • F.C.S. (South Africa) Gold Medal - Most Distinguished Candidate
    (1975)
  • South African Medical Research Council Overseas Scholarship
    (1976)
  • Wellcome Foundation Travelling Scholarship to Lausanne
    Wellcome Foundation (1977)
  • Wellcome Foundation Travelling Scholarship to London
    Wellcome Foundation (1978)
  • E. Storer Teaching Award
    Yale University, New Haven, CT (1985)
  • Harvard Medical School Eisenberg Memorial Lecture
    Brigham Hospital, Boston, MA (1988)
  • Fulbright Scholarship
    (1989)
  • Surgical Resident, Teaching Award
    Yale University, New Haven, CT (1992)
  • State-of-the-Art Lecturer
    British Society of Gastroenterology (1993)
  • I. N. Marks Memorial Lecture
    South African Gastroenterology Society (1994)
  • Polya Memorial Lecture
    Semmelweis University (1994)
  • England-Arris and Gale Lecturer
    Royal College of Surgeons (1995)
  • Theodor Kocher Memorial Lecture
    Swiss Surgical Society (1996)
  • State-of-the-Art Lecturer
    Japanese Society of Gastrointestinal Surgery (1997)
  • Fulton Society Lecture
    (1997)
  • Prout Society Lecture
    (1997)
  • Hunterian Professorship
    Royal College of Surgeons of England (1998)
  • The Beaumont Lecture
    (1999)
  • John Callum Memorial Oration
    (1999)

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