Irvin M Modlin, MD, FRCS (Eng & Ed), FCS (SA)

Research Organizations

Surgery

Research Summary

Dr. Irvin M. Modlin is currently studying the basis of gastric cancer development. This involves the generation of low acid states and the quantification of the neuroendocrine cell hyperplasia that is generated. These cells subsequently become tumors and can be transplanted and grown in nude mice. The individual cells can be isolated, purified, and studied, allowing close examination of their histamine secretion. Furthermore, confocal microscopy can be used to visualize the cells so as to delineate their vesicle movement and exocytosis. The cells are also studied through the use of fluorescent dyes, which identify fluxes of intracellular pH and calcium. These studies actually resemble those done in biopsy material from patients. Dr. Modlin's overall research goal is to identify isolated neuroendocrine cell function, evaluate its generation of growth factors and interface this with the development of alterations in cell lineage or proliferation which culminate in the development of carcinoma. The other studies in his laboratory involve the use of isolated membrane preparations from the colon and small bowel; the measurement of motility in isolated segments of small and large bowel; and the evaluation of subcellular zymogen trafficking and exocytosis.

Extensive Research Description

Dr. Irvin M. Modlin is currently studying the basis of gastric cancer development. This involves the generation of low acid states and the quantification of the neuroendocrine cell hyperplasia that is generated. These cells subsequently become tumors and can be transplanted and grown in nude mice. The individual cells can be isolated, purified, and studied, allowing close examination of their histamine secretion. Furthermore, confocal microscopy can be used to visualize the cells so as to delineate their vesicle movement and exocytosis. The cells are also studied through the use of fluorescent dyes, which identify fluxes of intracellular pH and calcium. These studies actually resemble those done in biopsy material from patients. Dr. Modlin's overall research goal is to identify isolated neuroendocrine cell function, evaluate its generation of growth factors and interface this with the development of alterations in cell lineage or proliferation which culminate in the development of carcinoma. The other studies in his laboratory involve the use of isolated membrane preparations from the colon and small bowel; the measurement of motility in isolated segments of small and large bowel; and the evaluation of subcellular zymogen trafficking and exocytosis.

Selected Publications

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Contact Info

Irvin M Modlin, MD, FRCS (Eng & Ed), FCS (SA)
Patient Care Location
Yale Surgical SpecialtiesYale Physicians Building
800 Howard Avenue, Ste 3rd Floor

New Haven, CT 06519
Office Location
Tompkins Memorial Pavilion
789 Howard Avenue, Ste Room 202

New Haven, CT 06519
Mailing Address
Yale SurgeryPO Box 208062
New Haven, CT 06520-8062