Immunobiology Faculty

       

Flavell, Richard A

Chair

Research Interests: Animal Models; Autoimmunity; Diabetes; Gene Expression; Gene Transfer; Genes; Immune System; Lyme Borreliosis Or Lyme Disease; Molecular Cellular Entities; Recombinant DNA; Transgenic Animals; Autoimmunity; Knockout Mice; Lyme Disease; T Cell Lineages; Tolerance; Transgenic Mice

       

Pober, Jordan Stuart

Vice-Chair of Immunobiology for Human and Translational Immunology

Research Interests: Immunobiology of vascular endothelial cells; Cytokine actions and mechanisms; Transplantation immunology

       

Bender, Jeffrey R.

Research Interests: Inflammatory, Immune, Metabolic and Hormonal Effects on the Endothelium

Clinical Interests: Clinical cardiology; preventive cardiology

Bothwell, Alfred L. M.

Research Interests: Human T cell recognition; Inflammation and cancer; Type 1 diabetes; Function of PPARs

Clinical Interests: Studies of human T cell recognition of human endothelial cells. The research goals of the Bothwell lab are to characterize the development and function of T cells and to characterize mechanisms that affect T cell recognition and recruitment into vascular sites. In addition, humanized mouse models are being established to study type 1 diabetes and breast cancer.

Chen, Lieping

Research Interests: Lymphocyte activation and tolerance; Costimulation and coinhibition; Tumor site immune modulation; Immunotherapy of advanced human cancer; Immunotherapy of advanced autoimmune diseases

Chi, Tian H

Research Interests: Epigenetic memory; Transgenerational inheritance; Chromatin biology

Craft, Joseph Edgar

Research Interests: Autoimmunity; Cytokines; Lupus; T Cell Differentiation; Tolerance

Clinical Interests: Systemic Lupus, Autoimmune Diseases

Cresswell, Peter

Research Interests: Molecular mechanisms of antigen processing; Assembly and intracellular transport of CD1 molecules, Class I and Class II MHC molecules; Effector functions; mechanisms of action of interferon-induced proteins; Viral immunity

Dhodapkar, Madhav V.

Research Interests: Myeloma and related plasma cell disorders; Human immune system's interaction with growing tumors in patients; Preneoplastic monoclonal gammopathy and multiple myeloma, tumor and host related factors

Clinical Interests: Multiple myeloma; monoclonal gammopathy of unknown significance (MGUS); immunobiology of cancers

Dixit, Vishwa Deep

Research Interests: Immune-Metabolic Interactions, Aging and age-related inflammation, Obesity-associated inflammation and metabolic syndrome, Adipose tissue leukocytosis, Inflammasomes, Thymic involution and approaches for thymic rejuvenation, Neuroendocrine control of immune system

Eisenbarth, Stephanie C

Research Interests: Pattern Recognition Receptors; NOD-like Receptors (NLRs); Dendritic Cells; T cells; Allergy/Asthma; Vaccines/Adjuvants; Red Blood Cell Alloimmunization; Autoimmune Diabetes; Influenza

Clinical Interests: The Clinical Immunology Laboratory integrates standard diagnostic immunology testing with an active flow cytometry and molecular diagnostics laboratory and therefore services a large and diverse patient population. The Immune Monitoring Core provides a core resource for clinical and translational research protocols at Yale School of Medicine that involve immunotherapy and/or that affect the human immune system. In addition to performing assays beyond the scope of routine clinical tests, this facility is involved in developing and utilizing new technologies and assays as needed for basic and clinical human studies on-going at Yale.

Goldstein, Daniel Robert

Research Interests: Immunity in transplantation; Impact of aging on inflammation and immunity

Clinical Interests: Clinical cardiology; heart failure/cardiac transplantation

Haberman, Ann M

Research Interests: B lymphocytes; Germinal center formation; Cell migration in vivo; Two-photon laser scanning microscopy

Hafler, David

Research Interests: Neuroimmunology; Multiple Sclerosis; Autoimmunity; Genetics; Immunobiology

Clinical Interests: Neuroimmunology and Multiple Sclerosis

Herold, Kevan

Research Interests: Type 1 diabetes; Immune therapy; Autoimmunity

Clinical Interests: Diabetes mellitus; hypoglycemia; endocrinology

Iwasaki, Akiko

Research Interests: Innate immunity; Autophagy; Inflammasomes; Sexually transmitted infections; Herpes simplex virus; Human papillomavirus; Respiratory virus infections; Influenza infection; T cell immunity; Commensal bacteria

Kaech, Susan

Research Interests: Mechanisms of memory T cell development; Developmental Biology; Immunobiology; Immunology; Vaccine; Immunobiology; T-Cells; Vaccines; Adaptive immunity and immunological memory to viruses

Kavathas, Paula B

Research Interests: Gene Regulation; Immunology; Molecular Cellular Entities; Receptors; Structure or Function (Health or Safety or Medical); Transgenic Animals

Kriegel, Martin Alexander

Research Interests: Microbiome; Commensals; Lymphocytes; Autoimmunity; Th17 cells; Antiphospholipid syndrome; Beta2-glycoprotein; Lupus; Type 1 diabetes

Clinical Interests: General Rheumatology; Systemic Autoimmune Diseases; Antiphospholipid Syndrome; Systemic Lupus Erythematosus; Vasculitis; Myositis

Medzhitov, Ruslan M

Research Interests: Inflammation; Allergy; Immunology; Innate Immunity; Pathophysiology

Meffre, Eric RF

Research Interests: Human B-cell tolerance; Primary immunodeficiencies; Autoimmune diseases

Pereira, João P.

Research Interests: Immunology; Hematopoiesis; B-lymphocyte development; Bone marrow niches; Cell migration

Rothlin, Carla Vanina

Research Interests: Regulation of inflammation; Homeostatic control of the immune system

Schatz, David G.

Research Interests: Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; Lymphocyte development; Mechanisms of DNA repair; Function of the RAG1 and RAG2 proteins; Mechanisms of lymphomagenesis

Shlomchik, Warren D

Research Interests: Mechanisms of antigen presentation; T cell effector function; Regulation of Graft-vs.-Host Disease and Graft-vs.-Leukemia

Clinical Interests: Bone marrow transplant

Su, Bing

Research Interests: MAP Kinase pathways; mTOR regulation; Receptor signaling; Cell growth control; Lymphocyte development and differentiation