Heather G Allore PhD
Associate Professor of Medicine (Geriatrics); Director, Yale Program on Aging Biostatistics Core
Research Interests
State transition models; experimental design; longitudinal methods; missing data methods; marginal structural models; latent class models; trajectory models; dynamic stochastic models; joint models
Current Projects
Dr. Allore's current research includes functional and mobility disability in the elderly, differences in immune system function of between young and older persons, age–related macular degeneration, multiple morbidity analysis, and falls in the elderly. She is also developing a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in geriatrics called “gerontologic biostatistics.” This discipline would train biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology.Research Summary
Dr. Allore's research is focused on issues related to the design and analysis of studies of multi-component interventions and the design and analysis of observational studies of multifactorial geriatric health conditions. Other areas of her applied research include developing strategies for handling missing data that frequently occurs in studies of older persons, applying extended Cox models for state transitions in geriatrics, such as frailty and disability that consist of multiple discrete states in which both onset and recovery are possible, and determining the mechanisms of action of an effective multi-component intervention. She has collaborated on several projects in immunology and is introducing new analytic methods to account for correlations among elements of the innate immune system. She is currently engaged in developing a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in geriatrics called "gerontologic biostatistics." This discipline would train biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology. She currently serves on the NIH Aging Systems and Geriatrics study section, VA Human Rights Committee, and CDC Special Emphasis study section. She has served as a reviewer and editorial board member for a variety of medical journals.
Selected Publications
- Tinetti ME, McAvary GJ, Murphy TE, Gross CP, Lin H, Allore HG. Contribution Of Individual Diseases To Death In Older Adults With Multiple Diseases. 2012. J Am Geriatr Soc. 60(8):1448-56.
- Murphy TE, McAvay G, Carriero NJ, Gross CP, Tinetti ME, Allore HG, Lin H. Deaths Observed in Medicare Beneficiaries: Average Attributable Fraction and its Longitudinal Extension for Many Diseases. 2012. Statistics in Medicine. PMIC: 22415597
- Lin H, Allore HG, McAvay G, Tinetti ME, Gill TM, Gross CP, Murphy TE. A Method for Partitioning the Attributable Fraction of Multiple Time-Dependent Co-existing Risk Factors for an Adverse Health Outcome. Amer J Public Health. 2012 PMID:22515873
- Murphy TE, Allore HG, Leo-Summers L, Carlin BP. Bayesian hierarchical modeling for a non-randomized, longitudinal fall prevention trial with spatially correlated observations. Statistics In Medicine, 2011 Feb 28;30(5):522-30. PMID:21294148
- Gill TM, Han L, Gahbauer E, Allore HG. Trajectories in the Last Year of Life. N Engl J Med. 2010. 362(13):1173-80. PMID: 20357280 PMCID: PMC2877372
- Gill TM, Allore HG, Gahbauer E, Murphy TE. Change in Disability after Hospitalization or Restricted Activity in Older Persons. JAMA. 2010 Nov 3;304(17):1919-28.PMID: 21045098.
- Murphy TE, Han L, Allore HG, Peduzzi PN, Gill TM, Lin H. Treatment of Death in the Analysis of Longitudinal Studies of Gerontologic Outcomes. Journal of Gerontology: A Biol Sci Med Sci. 2011 Jan;66(1):109-14. PMID: 21030467
- Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic Biostatistics: The Statistical Challenges of Clinical Research with Older Study Participants 2010 J Am Geriatr Soc. PMID: 20533963
- Tinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG. Effect of dissemination of evidence in reducing injuries from falls. N Engl J Med. 2008 359(3):252-61.
- Lin H, Guo Z, Peduzzi PN, Gill TM, Allore HG: A semiparametric transition model with latent traits for longitudinal multistate data. Biometrics. 2008 64(4):1032-42.
Selected Publications
- Tinetti ME, McAvary GJ, Murphy TE, Gross CP, Lin H, Allore HG. Contribution Of Individual Diseases To Death In Older Adults With Multiple Diseases. 2012. J Am Geriatr Soc. 60(8):1448-56.
- Murphy TE, McAvay G, Carriero NJ, Gross CP, Tinetti ME, Allore HG, Lin H. Deaths Observed in Medicare Beneficiaries: Average Attributable Fraction and its Longitudinal Extension for Many Diseases. 2012. Statistics in Medicine. PMIC: 22415597
- Lin H, Allore HG, McAvay G, Tinetti ME, Gill TM, Gross CP, Murphy TE. A Method for Partitioning the Attributable Fraction of Multiple Time-Dependent Co-existing Risk Factors for an Adverse Health Outcome. Amer J Public Health. 2012 PMID:22515873
- Murphy TE, Allore HG, Leo-Summers L, Carlin BP. Bayesian hierarchical modeling for a non-randomized, longitudinal fall prevention trial with spatially correlated observations. Statistics In Medicine, 2011 Feb 28;30(5):522-30. PMID:21294148
- Gill TM, Han L, Gahbauer E, Allore HG. Trajectories in the Last Year of Life. N Engl J Med. 2010. 362(13):1173-80. PMID: 20357280 PMCID: PMC2877372
- Gill TM, Allore HG, Gahbauer E, Murphy TE. Change in Disability after Hospitalization or Restricted Activity in Older Persons. JAMA. 2010 Nov 3;304(17):1919-28.PMID: 21045098.
- Murphy TE, Han L, Allore HG, Peduzzi PN, Gill TM, Lin H. Treatment of Death in the Analysis of Longitudinal Studies of Gerontologic Outcomes. Journal of Gerontology: A Biol Sci Med Sci. 2011 Jan;66(1):109-14. PMID: 21030467
- Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic Biostatistics: The Statistical Challenges of Clinical Research with Older Study Participants 2010 J Am Geriatr Soc. PMID: 20533963
- Tinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG. Effect of dissemination of evidence in reducing injuries from falls. N Engl J Med. 2008 359(3):252-61.
- Lin H, Guo Z, Peduzzi PN, Gill TM, Allore HG: A semiparametric transition model with latent traits for longitudinal multistate data. Biometrics. 2008 64(4):1032-42.
- Hardy SE, Allore H, Studenski SA. Missing Data: A Special Challenge in Aging Research. J Am Geriatr Soc. 2009
- Allore HG, Murphy TE. An Examination of Effect Estimation in Factorial and Standardly-Tailored Designs. Clin Trials 2008 5:121-130.
- Allore HG, Tinetti ME, Gill TM, Peduzzi PN. Experimental Designs for Multicomponent Interventions Among Persons With Multifactorial Geriatric Syndromes . Clin Trials 2005 2:13–21.
- Peduzzi P, Guo Z, Marottoli RA, Gill TM, Araujo K, Allore HG. Improved self–confidence was a mechanism of action in two geriatric trials evaluating multi–component physical interventions. J Clin Epid. 2007 60(1):94–102 .
- Van Ness PH, Murphy TE, Araujo KLB, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. J Clin Epidemiol. 2007 Dec60(12):1239-45.
- Allore HG, Tinetti ME, Araujo KL, Hardy S, Peduzzi PN. A case study found that a regression tree outperformed multiple linear regression in predicting the relationship between impairments and social and productive activities scores. J Clin Epid. 2005 58(2):154–161.
- Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore HG, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. . N Engl J Med. 2002 347:1068–1074.
- Fried TR, Bradley EH, Towle VR, Allore HG. Understanding seriously ill patients’ preferences for treatments and their outcomes. N Engl J Med. 2001 346:1061–1066.
