Hajime Tokuno MD

Assistant Professor of Neurology

Research Interests

Peripheral nerve injury; Muscle physiology; Clinical electrophysiology; EMG; EEG; chronic myofascial pain syndromes

Current Projects

1. The effect of botulinum toxins on chronic myofascial pain syndromes. We have one active study and one study in preparation looking at the benefits from botulinum toxins in individuals with chronic neck and back pain. The concept behind the use of botulinum toxins in subjects with chronic myofascial pain is based a belief that a significant part of the pain is due to uncontrolled muscular contraction due fibrosis and spasm.

2. The development of novel pain scoring. We are developing several new pathways of pain scoring that may better predict outcomes in new treatment modalities for chronic pain patients.

Research Summary

I have an interest in studying patients with chronic pain syndromes. I focus on subjects with myofascial pain syndromes, neuropathic pain and complex regional pain syndrome (a.k.a. reflex sympathetic dystrophy).

Selected Publications

  • Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Tokuno HA, Bradberry CW, Everill B, Agulian SK, Wilkes S, Baldwin RM, Tamagnan GD, Kocsis JD. Brain Res. 2004 Jan 23;996(2):159-67.
  • Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord. Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. J Neurosci. 2006 Feb 8;26(6):1803-12.

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