Guadalupe Garcia-Tsao MD
Professor of Medicine (Digestive Diseases); Chief, Digestive Diseases, VA-CT Healthcare System; Director, Clinical and Translational Core, Yale Liver Center; Program Director, VA-CT Hepatitis C Resource Center
Cirrhosis; natural history of cirrhosis; gastroesophageal varices; variceal hemorrhage; ascites; spontaneous bacterial peritonitis; hepatorenal syndrome
I am primarily involved in clinical research which focuses on cirrhosis and its complications. A major area of interest is describing the natural history of cirrhosis and its complications and the predictors of death at different stages. Another major area of interest is in the pathophysiology and treatment of portal hypertension, investigating the usefulness of portal-pressure reducing drugs and their impact in the prevention and treatment of gastroesophageal varices and variceal hemorrhage. I am also involved in the research of the development of bacterial infections in cirrhosis, a complication that is often overlooked and constitutes a rising complication of cirrhosis. Another area of research involves therapeutic modalities in the treatment of ascites which include the use of large volume paracentesis and transjugular intrahepatic portosystemic shunts, as well as therapeutic modalities to prevent the post-paracentesis circulatory dysfunction and the treatment of hepatorenal syndrome.