Genetics Faculty
Richard Lifton
Chairman
Sterling Professor of Genetics and Professor of Medicine (Nephrology)
Chair, Department of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Molecular genetics of common human diseases
Clinical Interests:Genetics
Allen Bale
Professor of Genetics
Director, DNA Diagnostic Lab
Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor
Clinical Interests:Cancer genetics; general genetics
Susan Baserga
Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology
Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing
William Breg, Jr
Professor Emeritus of Genetics
Martina Brueckner
Associate Professor of Pediatrics (Cardiology) and of Genetics
Research Interests:Development of left-right asymmetry; Heterotaxy syndrome; Kartagener syndrome; Situs inversus
Clinical Interests:General pediatric cardiology; genetics of congenital heart disease
Judy Cho
Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and Professor of Genetics and of Pediatrics (Gastroenterology)
Director, Inflammatory Bowel Disease Center
Research Interests:Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)
Clinical Interests:Inflammatory Bowel Disease (IBD)
Lynn Cooley
C. N. H. Long Professor of Genetics and Professor of Cell Biology and of Molecular, Cellular, and Developmental Biology
Director, Combined Program in the Biological & Biomedical Sciences
Research Interests:Molecular Genetics of Drosophila Oogenesis; Actin Cytoskeleton Regulation; Drosophila; Oogenesis; Ring Canal; Ovarian Muscle Function
Chris Cotsapas
Assistant Professor of Neurology and of Genetics
Research Interests:We use genetics, computational biology and cell-based approaches to discover and understand the mechanisms that give rise to disease. We are particularly interested in disorders of the immune system and brain.
Daniel DiMaio
Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center
Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence ; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus
Wayne Fenton
Research Scientist in Genetics
Research Interests:Protein folding; chaperonins; protein misfolding; amyotrophic lateral sclerosis; Lou Gehrig's disease
Patrick Gallagher
Professor of Pediatrics (Neonatology), of Genetics and of Pathology
Director, Yale Center for Blood Disorders
Director, Expression and Genomics Core, Yale Center of Excellence in Molecular Hematology
Research Interests:Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis
Clinical Interests:Neonatal medicine; Respiratory and circulatory failure; Shock; Prematurity; Newborn hematology and blood problems; Neonatal infectious disease; Genetic disorders
Joel Gelernter
Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neurobiology
Director, Division of Human Genetics (Psychiatry)
Research Interests:Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Gene mapping
Antonio Giraldez
Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies
Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish
Peter Glazer, MD, PhD
Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics
Chair, Department of Therapeutic Radiology
Research Interests:Gene targeting and gene therapy; Genetic instability in cancer; Mutagenesis; DNA repair; Radiation resistance; Cellular responses to radiation
Clinical Interests:General radiation therapy; breast cancer; prostate cancer; lung cancer
Valentina Greco
Assistant Professor of Genetics and of Dermatology
Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer
Jeffrey Gruen
Professor of Pediatrics (Neonatology) and of Genetics
Research Interests:Complex inherited traits including bladder exstrophy; Genetic susceptibility to newborn disorders; Genetics of reading disability (dyslexia)
Clinical Interests:Neonatal medicine; Inherited diseases; Neonatal hemochromatosis; newborn intensive care; dyslexia
Murat Gunel
Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology
Co-Director, Yale Program on Neurogenetics
Director, Neurovascular Surgery
Research Interests:Molecular genetics and biology of brain aneurysms and cavernous malformations; molecular genetics of brain development
Clinical Interests:Brain aneurysms; arterio-venous malformations (AVM); cavernous malformations; occlusive vascular disorders, carotid surgery; stereotactic radiosurgery; neurovascular intensive care unit (ICU); stroke
Marc Hammarlund
Assistant Professor of Genetics
Research Interests:Axon regeneration and degeneration; Neuronal plasticity; Femtosecond laser surgery; C. elegans neurobiology
Arthur Horwich
Sterling Professor of Genetics and Professor of Pediatrics
and Investigator HHMI
Research Interests:Chaperones in protein folding; ALS (Lou Gehrig's Disease)
Clinical Interests:Inborn errors of metabolism; Inherited neurodegenerative disease
Andrew Hudson
Research Scientist in Genetics
Natalia Ivanova
Assistant Professor of Genetics
Research Interests:Embryonic and somatic stem cells; Vertebrate development; Functional genomics; Systems biology
Mustafa Khokha
Associate Professor of Pediatrics (Critical Care) and of Genetics
Research Interests:Establishment of vertebrate body plan; Embryonic patterning and gene regulatory networks; Xenopus (frog) genetics
Clinical Interests:Genetics of congenital malformations, especially those that lead to critical illness
Judith Kidd
Research Interests:Human population genetics; forensic genetics
Kenneth Kidd
Professor of Genetics, of Ecology and Evolutionary Biology and of Psychiatry
Research Interests:Complex Human Disorders; Neuropsychiatric Disorders; Human Population ; Genetics; Human Evolution
Tae Hoon Kim
Assistant Professor of Genetics
Member, Yale Cancer Center
Member, Yale Stem Cell Center
Research Interests:Transcriptional Regulatory Elements and Chromatin Structure; Expression of the Cancer Genome; Epigenomics
Peining Li
Associate Professor of Genetics
Research Interests:Cytogenetic and genomic analysis; Dissection of genetic mechanisms for growth regulation, mental development, and cancer progression
Clinical Interests:Cytogenetics
Janghoo Lim
Assistant Professor of Genetics
Research Interests:Mechanisms of neural development, neurological disorders, and neurodegenerative diseases
Haifan Lin
Professor of Cell Biology and of Genetics
Director, Yale Stem Cell Center
Research Interests:RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells
Clinical Interests:Stem cell research
Jun Lu
Assistant Professor of Genetics
Research Interests:Non-coding RNAs in blood stem cell differentiation and malignancies; MicroRNA-mediated control of embryonic stem cell fates; MicroRNA mechanisms
Maurice Mahoney
Professor of Genetics, of Obstetrics, Gynecology, and Reproductive Sciences and of Pediatrics
Co-Chair, Embryonic Stem Cell Research Oversight Committee
Executive Director, Human Investigation Committee
Research Interests:Clinical Genetics; Diagnosis and Therapy of Human Fetal Disease; Research Ethics as Applied to Human Subjects
Clinical Interests:Prenatal Diagnosis; Clinical Genetics
Shrikant Mane
Senior Research Scientist in Genetics
Co-Director, MBB Keck Biotech Services
Director, Yale Center for Genome Analysis
Arya Mani
Associate Professor of Medicine (Cardiology) and of Genetics
Director, Cardiovascular Genetics Program
Research Interests:Identification of cardiovascular disorders that have strong familial pattern
Clinical Interests:General cardiology; adult familial cardiovascular disorders; congenital heart disease; coronary Computed Tomography (CT); arrythmia; cardiac echocardiography; cardiac nuclear stress testing; cardiovascular stress testing; fainting; nuclear cardiography; tachycardias; transesophageal echocardiography; CT angiography
Ellen Matloff
Research Scientist in Genetics
Director, Cancer Genetic Counseling
Research Interests:BRCA1; BRCA2; HNPCC; hereditary cancer; genetic patents; genetic counseling; genetic testing; sexuality and cancer; providers of genetic counseling
Clinical Interests:BRCA1; BRCA2; hereditary breast cancer; breast cancer; hereditary ovarian cancer; ovarian cancer; HNPCC; Lynch Syndrome; MSH2; MLH1; MSH6; hereditary colon cancer; FAP; Cowden syndrome; rare cancer syndromes; hereditary cancer syndromes; hereditary thyroid cancer; hereditary melanoma; hereditary pancreatic cancer; hereditary gastric cancer/lobular breast cancer; CDH1; retinoblastoma.
James McGrath
Research Scientist in Comparative Medicine, in Genetics and in Pediatrics
Research Interests:Developmental Genetics; Genetic Imprinting; Embryogenesis; Spermatogenesis
Clinical Interests:Clinical Genetics; Dysmorphology; Cardiac Genetics
Michael Nitabach
Associate Professor of Cellular and Molecular Physiology and of Genetics
Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior
James Noonan
Assistant Professor of Genetics
Member, Kavli Institute for Neuroscience
Member, Yale Cancer Center
Research Interests:Human Evolution; Evolutionary Dynamics of Gene Regulation; Synthetic Biology; Applications of Ultra-High Throughput Sequencing Technologies; Comparative and Functional Genomics in Vertebrates
In-Hyun Park
Assistant Professor of Genetics
Yale Stem Cell Center
Research Interests:Reprogramming; iPS cells; neurodevelopment; epigenetics
Charles Radding
Professor Emeritus of Genetics
Valerie Reinke
Associate Professor of Genetics
Research Interests:Functional genomic analysis of global gene expression mechanisms; C. elegans germline development; germline stem cells
G Shirleen Roeder
Eugene Higgins Professor Emeritus of Molecular, Cellular, and Developmental Biology and Professor of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Meiotic Chromosome Behavior; Cell Cycle Checkpoints; Meiotic Recombination; Synaptonemal Complex
Margretta Seashore
Professor of Genetics, of Laboratory Medicine and of Nursing
Interim Director, Biochemical Disease Detection Laboratory
Research Interests:Clinical Genetics; Inborn errors of metabolism, diagnosis and treatment
Clinical Interests:Genetic disorders; metabolic disorders; urea cycle disorders; organic acid and amino acid disorders in adults and children; mitochondrial disorders; newborn screening; genetic causes of developmental disability; inherited cardiomyopathies in adults and children.
Gerald Shadel
Professor of Pathology and of Genetics
Director, Pathology Research
Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling
Carolyn Slayman
Sterling Professor of Genetics and Professor of Cellular and Molecular Physiology
Deputy Dean for Academic & Scientific Affairs
Research Interests:Genetics of Ion Transport
Stefan Somlo
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Genetics
Chief, Section of Nephrology
Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function
Clinical Interests:Polycystic kidney disease; inherited or familial kidney disease; genetic aspects of kidney disease; polycystic liver disease
Matthew State
Donald J. Cohen Professor (Adjunct) in the Child Study Center and Professor of Genetics and of Psychiatry
Co-Director, Yale Program on Neurogenetics
Deputy Chairman for Research, Department of Psychiatry
Research Interests:Genetic mechanisms; neuropsychiatric disorders of childhood
Clinical Interests:Child and adolescent psychiatry; genetic syndromes; Tourette's syndrome; Obsessive/Compulsive Disorder (OCD); developmental delay; mental retardation
Zhaoxia Sun
Associate Professor of Genetics
Research Interests:Zebrafish genetics; Cilium; Kidney development; Polycystic kidney disease (PKD); Ciliopathy
Joann Sweasy
Professor of Therapeutic Radiology and of Genetics
Vice-Chair for Basic Research
Research Interests:Genome Stability; Mutagenesis; DNA Replication; DNA Repair; Carcinogenesis
Peter Tattersall
Professor of Laboratory Medicine and of Genetics
Research Interests:Biochemistry; Genetics; Parvoviruses; DNA replication; Gene therapy; Oncolytic virus; Vaccines; Vectors; Viral replication and vectors
Scott Weatherbee
Assistant Professor of Genetics
Research Interests:Limb development; Developmental genetics; Organogenesis; Mouse genetics; Signaling pathways; Embryogenesis
Sherman Weissman
Sterling Professor of Genetics
Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics
Andrew Xiao
Assistant Professor of Genetics
Research Interests:Chromatin biology: histone variants, modifications and chromatin remodeling complexes; Cellular reprogramming (iPS) and stem cell biology; Mammalian neural crest cell; Mammalian DNA damage response
Tian Xu
Professor of Genetics
Vice Chairman of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Genetic methodology; Cancer biology; Food and metabolism; Developmental mechanisms
Hui Zhang
Assistant Professor of Genetics and of Pediatrics
Clinical Interests:congenital malformations; dysmorphology; developmental delays; mental retardations; autism; craniofacial anomalies; hearing loss; ophthalmological disorders; CNS abnormalities.
Hongyu Zhao
Ira V. Hiscock Professor of Public Health (Biostatistics) and Professor of Genetics and of Statistics
Research Interests:statistical genomics; computational biology; genetic epidemiology; genome wide association studies; complex diseases; risk prediction; high dimensional data; dimension reduction; network models; graphical models; bioinformatics; next generation sequencing analysis; cancer genomics; epigenetics; herbal medicine; microbiome; proteomics
