Gang-Qing Yao MD

Research Scientist in Comparative Medicine; Director, Vector Design and Engineering Service

Departments & Organizations

Comparative Medicine

Research Interests

Molecular Biology of Bone Metabolism; Bone Metabolism; Endocrine effects on bone loss. Dr. Yao’s research interest focuses on cellular and molecular mechanisms of Colony Stimulating Factor-1 isoforms in bone. Selective deletion of the isoform in vivo is being pursued to better define their separate roles. The lab also provides a complete vector design and construction for knockout and knockin mice, as well as transgenic mice.

Education

• M.D., Shandong University, 1984

Selected Publications

• Yao GQ, Wu JJ, Troiano N, Zhu ML, Xiao XY, Insogna K. Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass and hypertriglyceridemia in mice. J Bone Miner Metab. In press.
• Yao GQ, Wu JJ, Troiano N, Insogna K. (2011) Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. J Bone Miner Metab 29:141–148
• Yao GQ, Wu JJ, Ovadia S, Troiano N, Sun BH, Insogna K.(2009) Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. American journal of physiology 296:E714-720