Enrique M. De La Cruz, PhD

Professor of Molecular Biophysics and Biochemistry

Research Organizations

Molecular Biophysics and Biochemistry: E De La Cruz Lab

Research Summary

Identifying the chemical and physical principles of work production by molecular motor protein enzymes and polymers has emerged as a major area in contemporary Biochemistry and Biophysics. My research program integrates comprehensive kinetic and thermodynamic analyses of catalytic reaction pathways with computational and mathematical modeling to develop and test predictive models of work output by molecular motor proteins, enzyme function and adaptation, and biopolymer fragmentation. Our work has revealed how enzymatic adaptations among evolutionary related molecular motor proteins determine their biological function, and how cells regulate the length and assembly dynamics of polymers that drive cell movement.

Our current and future efforts focus primarily in three areas:

A) identifying the molecular origins of actin filament elasticity and the mechanical basis of filament severing by regulatory proteins;

B) defining how ATP utilization by DEAD-box proteins (DBPs) is coupled to duplex rRNA unwinding; and

C) determining the catalytic pathways, specificities and biological activities of nucleotide pyrophosphatase/phosphodiesterase (NPP) enzymes.

Extensive Research Description

Persistence software can be found on our Lab page.

Selected Publications

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Contact Info

Enrique M. De La Cruz, PhD
Mailing Address
MB and BPO Box 208114
260 Whitney Avenue

New Haven, CT 06520-8114

Lab Site