Deepak Cyril D'Souza, MBBS, MD

Professor of Psychiatry; Director Schizophrenia Research Program VACHS; Director, Neurobiological Studies Unit, VACHS; Director, VA-CMHC Schizophrenia Research Clinic

Research Interests

Behavior and Behavior Mechanisms; Mental Disorders; Behavioral Disciplines and Activities; Psychological Phenomena and Processes; Psychiatry and Psychology

Research Organizations

Psychiatry: Clinical Neuroscience Research Unit | Schizophrenia Research Clinic

Research Summary

Our group has been studying the treatment and pathophysiology of schizophrenia. Our work involves the use of various psychopharmacological probes (ketamine, delta-9-THC, iomazenil, etc) to evaluate the contributions of various neurotransmitter systems (NMDA, cannabinoid, GABA, etc) to the pathophysiology of schizophrenia; laboratory studies of comorbid substance abuse in schizophrenia, (alcohol, cannabis and nicotine) and clinical trials with novel agents for schizophrenia.

Extensive Research Description


    • Neurobiology of Cannabis
    • Cannabinoids, Neural Synchrony and Information Processing
    • Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    • Imaging Nicotinic Acetylcholine Receptors in Schizophrenia
    • GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis
    • GABA Deficits and Vulnerability to Amphetamine-Induced Psychosis
    • Ketamine Nicotine Interactions in Humans
    • Ketamine Interactions with GLYT1 inhibitor in Humans
    • Cognitive Remediation in the Schizophrenia Trials Network
    • Varenicline for Smoking Cessation in Schizophrenia
  • Selected Publications

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    Contact Info

    Deepak Cyril D'Souza, MBBS, MD
    Patient Care Locations
    Clinical Neuroscience Research InstituteConnecticut Mental Health Center
    34 Park Street, Ste 3rd Floor

    New Haven, CT 06519
    Psychiatry ServiceVA Connecticut Healthcare
    950 Campbell Avenue, Ste Suite 116A

    West Haven, CT 06516
    Lab Location
    Neurobiological Studies UnitVA Connecticut Healthcare
    950 Campbell Avenue, Ste 9th Floor

    West Haven, CT 06516
    Office Location
    VA Connecticut Healthcare
    950 Campbell Avenue, Ste 7th Floor

    West Haven, CT 06516
    Mailing Address
    Psychiatry Service 116A, VACHS950 Campbell Avenue
    West Haven, CT 06516