Deborah Denise Proctor, MD

Professor of Medicine (Digestive Diseases); Medical Director, Inflammatory Bowel Disease Program; Site Director, Universidad del Valle, Cali, Columbia and Yale/Stanford, Johnson and Johnson Global Health Scholar Program; Board of Directors and Treasurer, Honduras Children's Project

Research Interests

Colitis, Ulcerative; Crohn Disease; Gastrointestinal Hemorrhage; Ileitis; Rectal Fistula; Telangiectasia, Hereditary Hemorrhagic; Global Health; Inflammatory Bowel Diseases

Public Health Interests

Global Health

Research Organizations

Internal Medicine: Digestive Diseases

Faculty Research

Office of Cooperative Research

Research Summary

Our IBD Program group does clinical research with inflammatory bowel disease (IBD) patients including evaluating and treating depression in patients with inflammatory bowel disease and setting up databases to correlate genotype with phenotypic expression. We participate in several international multi-center trials for different medications and databases.

Our HHT group does clinical research in patients with hereditary hemorrhagic telangiectasia (HHT) who also have gastrointestinal (GI) bleeding.

Specialized Terms: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Hereditary Hemorrhagic Telangiectasia

Extensive Research Description

Inflammatory bowel disease - our IBD Program group does clinical research with inflammatory bowel disease (IBD) patients including evaluating and treating depression in patients with inflammatory bowel disease and setting up databases to correlate genotype with phenotypic expression. We participate in several international multi-center trials for different medications and databases.

HHT - Along with other members of our HHT Center, our group does clinical research in patients with hereditary hemorrhagic telangiectasia (HHT) who also have gastrointestinal (GI) bleeding.

GI Match - Collaborating with other colleagues, we have done research on the GI fellowship match.

1. Treating depression in patients with inflammatory bowel disease

2. Multi-center trials for new drugs in inflammatory bowel disease

3. Correlation of genotype with phenotypic expression in patients with inflammatory bowel disease

4. Global health training attitudes in trainees

Selected Publications

  • EMerging BiomARKers in inflammatory bowel disease (EMBARK) study identifies fecal calprotectin, serum MMP9 and serum IL-22 as a novel combination of biomarkers for Crohn's disease activity - role of cross-sectional imaging.

    Faubion WA, Fletcher JG, O'Byrne S, Feagan BG, de Villiers WJS, Salzberg B, Plevy S, Proctor DD, Valentine JF, Higgins PD, Harris JM, Diehl L, Wright L, Tew GW, Luca D, Basu K, Keir ME. EMerging BiomARKers in inflammatory bowel disease (EMBARK) study identifies fecal calprotectin, serum MMP9 and serum IL-22 as a novel combination of biomarkers for Crohn's disease activity - role of cross-sectional imaging. American Journal of Gastroenterology 2013; 108:1891–1900; doi:10.1038/ajg.2013.354; published online 15 October 2013.

  • Missionary work – it’s about more than doing endoscopies. Proctor DD. Missionary work – it’s about more than doing endoscopies. AGA Perspectives 2013;9(3):22-23.
  • The influence of depression on quality of life in patients with inflammatory bowel disease.

    Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD. The influence of depression on quality of life in patients with inflammatory bowel disease. Inflammatory Bowel Diseases 2013;19(8):1732-1739.

  • The process of applying for gastroenterology fellowship.

    DeCross AJ, Proctor DD. The process of applying for gastroenterology fellowship. Gastroenterology 2012;142(7):1405-1408.

  • A genome-wide scan of Ashkenazi Jewish Crohn’s disease suggests novel susceptibility loci.

    Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, McGovern DPB, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I. A genome-wide scan of Ashkenazi Jewish Crohn’s disease suggests novel susceptibility loci. PLoS Genetics 2012;8(3):e1002559.

  • Getting to the core of the women’s curriculum – it’s time to change the way we train our fellows.

    Proctor DD. Getting to the core of the women’s curriculum – it’s time to change the way we train our fellows. Digestive Diseases and Sciences 2011;56(3):626-628 (Editorial).

  • The match: five years later.

    Proctor DD, DeCross AJ, Willis CE, Jones TN, Pardi DS. The match: five years later. Gastroenterology 2011;140(1):15-18.

  • Report of the AGA Institute Education and Training Committee Task Force on Physician Reentry.

    DeCross AJ, Pardi DS, Proctor DD. Report of the AGA Institute Education and Training Committee Task Force on Physician Reentry. Gastroenterology 2010;139:e17-e26.

  • Response to the Institute of Medicine’s recommendations on resident duty hours: the medical residency program and GI fellowship viewpoints.

    Katzka DA, Proctor DD. Response to the Institute of Medicine’s recommendations on resident duty hours: the medical residency program and GI fellowship viewpoints. Gastroenterology 2009;136(4):1147-1148.

  • Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository.

    Bhat M, Nguyen GC, Pare P, Lahaie R, Deslandres C, Bernard EJ, Aumais G, Jobin G, Wild G, Cohen A, Langelier D, Brant S, Dassopoulos T, McGovern D, Torres E, Duerr R, Regueiro M, Silverberg MS, Steinhart H, Griffiths AM, Elkadri A, Cho J, Proctor D, Goyette P, Rioux J, Bitton A. Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository. Am J Gastro 2009;104(9):2233-40.

  • Ulcerative colitis-risk loci on chromosomes 1p36 and 12p15 identified by genome-wide association study.

    Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Pare P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH. Ulcerative colitis-risk loci on chromosomes 1p36 and 12p15 identified by genome-wide association study. Nature Genetics, 41:216-220, 2009.

  • International guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia.

    Faughnan ME, Palda VA, Garcia-Tsao G, Geisthoff UW, McDonald J, Proctor DD, Spears J, Brown DH, Buscarini E, Chesnutt MS, Cottin V, Ganguly A, Gossage JR, Guttmacher AE, Hyland RH, Kennedy SJ, Korzenik J, Mager JJ, Ozanne AP, Piccirillo JF, Picus D, Plauchu H, Porteous MEM, Pyeritz RE, Ross DA, Sabba C, Swanson K, Terry P, Wallace MC, Westermann CJJ, White RI, Young LH, Zarrabeitia R. International guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia. Journal of Medical Genetics 2011;48:73-87. First published online: 23 June 2009; doi:10.1136/jmg.2009.069013.

  • The gastroenterology fellowship match – the first two years.

    Niederle M, Proctor DD, Roth AE. The gastroenterology fellowship match – the first two years. Gastroenterology 2008;135(2):344-346.

  • Rockey DC, Harrison SA, Wong RKH, Schiller LR, Proctor DD, Wolfe MM, Chutkan R, Vargo JJ, Waxler A. The gastroenterology core curriculum, third edition – May 2007. Gastroenterology 2007132(5):2012-2018.
  • Hormonal therapy for the treatment of gastrointestinal bleeding in hereditary hemorrhagic telangiectasia.

    Proctor DD, Henderson KJ, Dziura JD, White RI. Hormonal therapy for the treatment of gastrointestinal bleeding in hereditary hemorrhagic telangiectasia. J Clin Gastroenterology 2007.

  • JAK2 disease-risk variants are gain of function and JAK signaling threshold determines innate receptor-induced proinflammatory cytokine secretion in macrophages. Hedl M, Proctor DD, Abraham C. JAK2 disease-risk variants are gain of function and JAK signaling threshold determines innate receptor-induced proinflammatory cytokine secretion in macrophages. Journal of Immunology 2016;197:3695-3704.
  • Global health education in gastroenterology fellowship: a national survey. Jirapinyo P, Hunt RS, Tabak YP, Proctor DD, Makrauer FL. Global health education in gastroenterology fellowship: a national survey. Digestive Diseases and Sciences 2016; 61:3443-3450.
  • A pleiotropic missense variant in SLC39A8 is associated with Crohn’s disease and human gut microbiome composition. Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, DAmato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Buning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan S, Torkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DPB, Duerr RH. A pleiotropic missense variant in SLC39A8 is associated with Crohn’s disease and human gut microbiome composition. Gastroenterology 2016;151:724-732.
  • Appendectomy does not decrease the risk of future colectomy in ulcerative colitis: results from a large cohort and meta-analysis. Parian A, Limketkai B, Koh J, Brant SR, Bitton A, Cho JH, Duerr RH, McGovern DP, Proctor DD, Reguiero MD, Rioux JD, Schumm PP, Taylor KD, Silverberg MS, Steinhart AH, Hernaez R, Lazarev M. Appendectomy does not decrease the risk of future colectomy in ulcerative colitis: results from a large cohort and meta-analysis. Gut 2016;0:1-8.
  • Introduction to the “Fellows and Young GIs Section”. To U, Proctor DD. Introduction to the “Fellows and Young GIs Section”. Digestive Diseases and Sciences, 2016.
  • Bernasko N, Proctor D. Invited commentary. Characteristics and Behavior of Elderly-Onset Inflammatory Bowel Disease: A Multi-Center US Study. PracticeUpdate website. Available at: http://www.practiceupdate.com/content/characteristics-and-behavior-of-elderly-onset-inflammatory-bowel-disease/43340/65/9/1. Accessed September 08, 2016. 

Full List of PubMed Publications

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Contact Info

Deborah Denise Proctor, MD
Patient Care Locations
Yale Digestive DiseasesTemple Medical Center
40 Temple Street, Ste Suite 1A

New Haven, CT 06510
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Yale Digestive DisordersYale Health Center
55 Lock Street

New Haven, CT 06511
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Yale Digestive DiseasesYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Mailing Address
40 Temple Street
Suite 1A

New Haven, CT 06510

Curriculum Vitae

Research Image 1

Honduras Children's Project's President Davey Proctor teaching at Copprome Orphanage June 2014

Research Image 2

Honduras Children's Project took the children swimming June 2014

Research Image 3

Honduras Children's Project at Copprome Orphanage June 2013