David A. Calderwood PhD
Associate Professor of Pharmacology and of Cell Biology
Departments & Organizations
Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Cytoskeleton and Cell Morphogenesis | Biochemistry, Biophysics and Structural Biology: Cell Cycle and Signal Transduction; Membrane Biology and Motion; Protein Folding, Dynamics and Degradation
Signal Transduction
Vascular Biology and Therapeutics Program
Cell Biology
Pharmacology
Diabetes Endocrinology Research Center
Signal Transduction
Research Interests
Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology more...
Education
- Ph.D., University of Manchester, UK, 1996
Selected Publications
- Goult B. T, Bouaouina, M., Elliott, P.R., Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL. (2010) Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 29(6):1069-80.
- Harburger DS, Bouaouina M, Calderwood DA. (2009) Kindlin-1 and -2 directly bind the C-terminal region of ß integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem. 284(17):11485-97. Epub 2009 Feb 23.
- Chiswell B. P., Zhang R., Murphy J. W., Boggon T. J. and Calderwood D. A. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. U.S.A. 105, 20677-20682
