Chuhan Chung, MD

Associate Professor of Medicine (Digestive Diseases)

Departments & Organizations

Internal Medicine: Digestive Diseases | Liver Center

Faculty Research

Stem Cell Center, Yale

Office of Cooperative Research


I am a clinician-scientist with an interest in the matricellular proteins, PEDF and TSP-1, which are best known as inhibitors of angiogenesis. The recent identification of the PEDF null state as the cause of Osteogenesis Imperfecta (OI) Type VI has illuminated its biology. Specifically, the phenotypes associated with high PEDF conditions (metabolic syndrome, adiposity) and null PEDF states (OI Type VI) indicate that PEDF functions to regulate mesenchymal stem cell (MSC) lineage specification. Based on these clinical insights, we have demonstrated that PEDF can direct MSC fate. This is significant because previous unbiased proteomic screens have postulated PEDF's role in stem cell pluripotency. This rare single gene null state has allowed us to interrogate PEDF's role in other more common disease conditions.

Education & Training

MD Medical College of Pennsylvania (1998)
BA Wesleyan University (1989)
Research Fellow Northwestern University School of Medicine
Clinical Fellow Northwestern University School of Medicine
Resident Northwestern University
Intern Northwestern University School of Medicine

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Contact Info

Chuhan Chung, MD
Patient Care Location
Yale Digestive DiseasesYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Mailing Address
PO Box 208056
333 Cedar Street

New Haven, CT 06520-8056
The PEDF null state in mice recapitulates human Osteogenesis Imperfecta Type VI

Identification of the PEDF null state in humans (OI Type VI) has distilled PEDF biology.