Diagnostic Imaging; Education, Medical; Emergency Medicine; Pulmonary Embolism; Ultrasonography; Renal Colic
Dr. Moore's research interests are primarily in the area of diagnostic imaging in the emergency department, including ultrasound and CT. He is currently funded by the Agency for Healthcare Research and Quality (AHRQ) to disseminate the appropriate use of reduced-dose CT protocols for renal colic (kidney stone).
Other interests include bedside ultrasound, pulmonary embolism (PE), aortic dissection, kidney stones, bedside echocardiography, and emergency ultrasound education.
In 2009 Dr. Moore received the Society for Academic Emergency Medicine "Ultrasound Achievement Award"; a national award for "Exceptional Academic Accomplishments and Leadership in Emergency Ultrasound".
Extensive Research Description
My research has focused around the use of diagnostic imaging in the emergency department patient. I am fellowship trained in emergency ultrasound, and much of my research has focused the application of "point-of-care" or bedside ultrasound in the emergency patient. This led me to an interest in reducing unnecessary CT scans, particularly in patients with suspected kidney stone. Our work, currently funded by the Agency for Healthcare Research and Quality (AHRQ) has led to development of the "STONE score", a clinical prediction tool for ureteral stone, as well as efforts to optimize radiation dose in CT scan and to disseminate this practice nationally.
Ultrasound has been described as "the stethoscope of the future" and with advances in machine size, quality, this is finally beginning to be a reality. However, ultrasound is a user-dependent technology whose efficacy is largely dependent on the training of the person obtaining and interpreting images. I remain interested in investigating how this tool is best used in the emergency department and other settings as well as providing effective education and assessment of competency.
I have now run a fellowship in emergency ultrasound for twelve years as well as rotations for residents and medical students. Prior work I have completed has focused on the bedside evaluation of left ventricular function in patients with hypotension or dyspnea. We have also looked at screening for abdominal aortic aneurysms and the prognostic value of peritoneal free fluid in patients with suspected ectopic pregnancy. I have also looked at issues regarding penetration of ultrasound technology into academic and community settings.
In addition to our work on imaging in renal colic we have ongoing projects include expanding the utility of bedside ultrasound in the evaluation of fluid responsiveness and pulmonary embolism, and a multi-center trial of ribaraoxavan for outpatient treatment of pulmonary embolism.
- Hall MK, Taylor RA, Luty S, Allen IE, Moore,CL. American Journal of Emergency Medicine, 2016; 34(6), 1022–1030. http://doi.org/10.1016/j.ajem.2016.02.059
- Moore CL, Daniels B, Singh D, Luty S, Gunabushanam G, Ghita M, Molinaro A, Gross CP. Radiology 2016, 151691. http://doi.org/10.1148/radiol.2016151691
- Pare JR., Liu R, Moore CL, Sherban T, Kelleher MS, Thomas S, Taylor RA. American Journal of Emergency Medicine, 34(6), 1022–1030. http://doi.org/10.1016/j.ajem.2016.02.059
- Hall MK, Omer T, Moore CL, Taylor RA: Cost-Effectiveness of the Cardiac Component of the FAST Examination in Blunt Trauma. Acad Emerg Med. 2016 Feb 9
- Daniels, B., Gross, C. P., Molinaro, A., Singh, D., Luty, S., Jessey, R., & Moore, C. L. (2015). STONE PLUS: Evaluation of Emergency Department Patients With Suspected Renal Colic, Using a Clinical Prediction Tool Combined With Point-of-Care Limited Ultrasonography. Ann Emerg Med. 2015 Dec 31
- Kanzaria, H. K., Hall, M. K., Moore, C. L., & Burstin, H. (2015). Emergency Department Diagnostic Imaging: The Journey to Quality. Acad Emerg Med. 2015 Dec;22(12):1380-4
- Moore CL, Broder J, Gunn ML, Bhargavan-Chatfield M, Cody D, Cullison K, Daniels B, Gans B, Hall MK, Gaines BA, Goldman S, Heil, J, Liu R, Marin J, Melnick E, Novelline RA, Pare J, Repplinger MD, Taylor RA, Sodickson AD. Acad Emerg Med 2015; 20:1465-1473.
- Pare JR, Moore CL. Journal of Patient Safety, 2015, 1–3. http://doi.org/10.1097/PTS.0000000000000233
- Moore CL. Annals of Emergency Medicine 2015;66(2), 215. http://doi.org/10.1016/j.annemergmed.2015.04.015
- Walsh BM, Moore CL. Journal of Emergency Medicine, 2015; 49(3), 301–304. http://doi.org/10.1016/j.jemermed.2014.12.089
- Hall MK, Rizzollo L, Moore CL. The student’s dilemma, liver edition: Incorporating the sonographer’s language into clinical anatomy education. Anat Sci Education 2015 8(3):283-8.
- Russell FM, Moore CL, Courtney DM, Kabrhel C, Smithline HA, Nordenholz KE, Richman PB, O'Neil BJ, Plewa MC, Beam DM, Mastouri R, Kline JA. Am J Emerg Med, 2015; 33(4), 542–547. http://doi.org/10.1016/j.ajem.2015.01.026
- Hall MK, Coffey D, Herbst M, Liu R, Pare J, Taylor RA, Thomas S, Moore CL. The “5Es” of Emergency Physician-performed Focused Cardiac Ultrasound: a Protocol for Rapid Identification of Effusion, Ejection, Equality, Exit, and Entrance. Acad Emerg Med, 2015; 22(5):583-93.
- Samim M, Goss S, Luty S, Weinreb J, Moore CL. Incidental findings on CT for suspected renal colic in emergency department patients: prevalence and types in 5,383 consecutive examinations. J Am Coll Radiol, 2015; 12:63-69.
- Herbst MK, Camargo CA, Perez A, Moore CL. Use of point-of-care ultrasound in Connecticut emergency departments. J Emerg Med,2015; 48(2):191-196.
- Moore CL, Daniels B, Ghita M, Gunabushanam G, Luty S, Molinaro AM, Singh Dinesh, Gross CP. Accuracy of reduced-dose computed tomography for ureteral stones in emergency department patients. Ann Emerg Med, 2015;65(2):189-98.
- Ashurst JV, Cherny AR, Evans EM, Hall MK, Hess EP, Kline JA, Mitchell AM, Mills AM, Weigner MB, Moore CL. Research priorities for the influence of gender on diagnostic imaging choices in the emergency department setting. Acad Emerg Med, 2014; 21:1431-1437.
- Moore CL. Ultrasound first, second, and last for vascular access. J Ultrasound Med 2014;33:1135-1142.
- Moore CL, Bomann S, Daniels B, Luty S, Molinaro A, Singh D, Gross CP. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone – the STONE score: retrospective and prospective observational cohort studies. BMJ 2014;348:g2191.
- Lukasiewicz A, Bhargavan M, Coombs L, Ghita M, Weinreb J, Gunabushanam G, Moore CL. Radiation Dose Index of Renal Colic Protocol CT Scans in the United States: A Report from the American College of Radiology National Radiology Data Registry. Radiology 2014; 271: 445-451.
- Taylor RA, Moore CL. Accuracy of emergency physician-performed limited echocardiography for right ventricular strain. Am J Emerg Med 2014;32:371-374.
- Kotlyar S, Nteziyaremye J, Oluput-Oluput P, Akech SO, Moore CL, Maitland K. Spleen volume and clinical manifestations of severe Plasmodium falciparum malaria in African children. Trans R Soc Trop Med Hyg 2014;108(5):283-9.
- Herbst MK, Rosenberg G, Daniels B, Gross CP, Singh D, Molinaro AM, Luty S, Moore CL. Effect of provider experience on clinician performed ultrasound for hydronephrosis in patients with suspected renal colic. Ann Emerg Med 2013; 20:470-478. http://www.ncbi.nlm.nih.gov/pubmed/24630203
- Thomas S, Moore CL. The Vanishing Target Sign: Confirmation of Intraluminal Needle Position for Ultrasound Guided Vascular Access. Acad Emerg Med 2013 20(10):e17-e18. http://www.ncbi.nlm.nih.gov/pubmed/24127720
- Hall MK, Spiro DM, Sabbaj A, Moore CL, Hopkins KL, Meckler GD. Bedside optic nerve sheath diameter ultrasound for the evaluation of suspected pediatric ventriculoperitoneal shunt failure in the emergency department. Childs Nerv Syst 2013; 29:2275-2280.
- Taylor RA, Davis J, Moore CL. Point-of-care Focused Cardiac Ultrasound for Prediction of Pulmonary Embolism Adverse Outcomes. J Emerg Med 2013; 45(3): 392-399. http://www.ncbi.nlm.nih.gov/pubmed/23827166
- Daniels B, Singh D, Luty S, Molinaro A, Gross C. Prevalence and Clinical Importance of Alternative Causes of Symptoms Using a Renal Colic Computed Tomography Protocol in Patients with Flank or Back Pain and Absence of Pyuria. Acad Emerg Med 2013; 20(5): 470-478. http://www.ncbi.nlm.nih.gov/pubmed/23672361
- Moore CL (chair of committee), AIUM Practice Guideline: Use of ultrasound to guide vascular access procedures. J Ultrasound Med 2013; 32: 191-215. http://www.aium.org/resources/guidelines/usgva.pdf
- Moore CL, Scoutt Leslie. Sonography first for acute flank pain? J Ultrasound Med 2012; 31: 1703-1711.http://www.ncbi.nlm.nih.gov/pubmed/23091240
- Venkatesh AK, Kline JA, Courtney DM, Camargo CA, Plewa MC, Nordenholz KE< Moore CL, Richman PB, Smithline HA, Beam DM, Kabrhel C. Evaluation of pulmonary embolism in the emergency department and consistency with a national quality measure: quantifying the opportunity for improvement. Arch Intern Med 2012; 1028-1032. http://www.ncbi.nlm.nih.gov/pubmed/22664742
- Dodge KA, Lynch CA, Moore CL, Birosack BJ, Evans LV. Use of ultrasound guidance improves central venous catheter insertion success rates among junior residents. J Ultrasound Med 2012; 31:1519-1526. http://www.ncbi.nlm.nih.gov/pubmed/23011614
- Kotlyar S, Larkin GL, Moore CL, D’Onofrio G. S100B Immunoassay: an assessment of diagnostic utility in minor head trauma. J Emerg Med 2011; 41(3):285-293. http://www.ncbi.nlm.nih.gov/pubmed/20692788
- Gilbert JW, Johnson KM, Larkin GL, Moore CL. Atraumatic headache in US emergency departments: recent trends in CT/MRI utilisation and factors associated with severe intracranial pathology. Emerg Med J 2012;29(7):576-81. http://www.ncbi.nlm.nih.gov/pubmed/21856709
- Moore CL. Ultrasound-guided procedures in emergency medicine. Ultrasound Clin 2011; 6(2): 277-289. http://www.ultrasound.theclinics.com/article/S1556-858X%2811%2900018-1/abstract
- Manson WC, Bonz JW, Carmody K, Osborne M, Moore CL. Identification of Sonographic B-lines with Linear Transducer Predicts Elevated B-Type Natriuretic Peptide Level. West J Emerg Med 2011; 12(1):102-106. http://www.ncbi.nlm.nih.gov/pubmed/21691481
- Moore CL. Credentialing and reimbursement in point-of-care ultrasound. Clin Ped Emerg Care 2011. 12(1): 73-77. http://www.sciencedirect.com/science/article/pii/S1522840110000923
- Moore CL, Copel JA. Current concepts: point-of-care ultrasonography. N Engl J Med 2011; 364(8): 749-757. http://www.nejm.org/doi/full/10.1056/NEJMra0909487
- Markowitz JE, Hwang JQ, Moore CL. Development and validation of a web-based assessment tool for the extended focused assessment with sonography in trauma examination. J Ultrasound Med 2011; 30:371-375. http://www.ncbi.nlm.nih.gov/pubmed/21357559
- Maru DS, Schwarz R, Andrews J, Basu S, Sharma A, Moore CL. Turning a blind eye: the mobilization of radiology services in resource-poor regions. Globalization and Health 2010; 6(18): 1-8. http://www.ncbi.nlm.nih.gov/pubmed/20946643
- Evans LV, Dodge KL, Shah TD, Kaplan LJ, Siegel MD, Moore CL, Hamann CJ, Lin ZQ, D’Onofrio GD. Simulation training in central venous catheter insertion: improved performance in clinical practice. Acad Med 2010; 85(9): 1462-1469. http://www.ncbi.nlm.nih.gov/pubmed/20736674
- Moore CL, Tham ET, Samuels KJ, McNamara RL, Galante NJ, Stachenfeld N, Shelley K, Dziura J, Silverman DG. Tissue Doppler of early mitral filling correlates with simulated volume loss in healthy subjects. Acad Emerg Med 2010; 17(11): 1162-1168. http://www.ncbi.nlm.nih.gov/pubmed/21175513
- Courtney DM, Kline JA, Kabrhel C, Moore CL, Smithline HA, Nordenholz KE, Richman PB, Plewa MC. Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study. Ann Emerg Med 2010; 55(4): 307-315. http://www.ncbi.nlm.nih.gov/pubmed/20045580
- Beam DM, Courtney DM, Kabrhel C, Moore CL, Richman PB, Kline JA. Risk of thromboembolism varies, depending on category of immobility in outpatients. Ann Emerg Med 2009; 54(2):147-152. http://www.ncbi.nlm.nih.gov/pubmed/19135280
- Schuster KM, Lofthouse R, Moore CL, Lui F, Kaplan LJ, Davis KA. Pulseless electrical activity, focused abdominal sonography for trauma, and cardiac contractile activity as predictors of survival after trauma. J Trauma, 2009; 67(6): 1154-1157. http://www.ncbi.nlm.nih.gov/pubmed/20009660
- Moore CL, Meyers AB, Capotasto J, Bokhari J. Prevalence of abnormal CT findings in patients with proven ovarian torsion and a proposed triage schema. Emerg Radiol 2009; 16:115–120. http://www.ncbi.nlm.nih.gov/pubmed/18679730
- Kabrhel C, Courtney DM, Camargo CA, Moore CL, Richman PB, Plewa MC, Nordenholz KE, Smithline HA, Beam DA, Brown MD, Kline JA. Potential impact of adjusting the threshold of the quantitative D-dimer based on pretest probability of acute pulmonary embolism. Acad Emerg Med, 2009; 16(4):325-332. http://www.ncbi.nlm.nih.gov/pubmed/19298619
- Moore CL, Holliday SR, Hwang JQ, Osborne MR. Screening for abdominal aortic aneurysm in asymptomatic at-risk patients using emergency ultrasound. Am J Emerg Med 2008; 26: 883-887. http://www.ncbi.nlm.nih.gov/pubmed/18926345
- Kotlyar S, Moore CL. Assessing the utility of ultrasound in Liberia. J Emerg Trauma Shock 2008; 1:1: 10-14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700563/
- Kline JA, Courtney DM, Kabrhel C, Moore CL, et al. Prospective multicenter validation of the pulmonary embolism rule-out criteria. J Thromb Haem, 2008; 6: 772-780. http://www.ncbi.nlm.nih.gov/pubmed/18318689
- Moore CL. Current issues with emergency cardiac ultrasound probe conventions. Acad Emerg Med 2008; 15(3): 278-284. http://www.ncbi.nlm.nih.gov/pubmed/18304059
- Chen L, Kim Y, Moore CL. Diagnosis and guided reduction of forearm fractures in children using bedside ultrasound. Ped Emerg Care 2007; 23(8): 528-531. http://www.ncbi.nlm.nih.gov/pubmed/17726410
- Moore CL, Todd WM, O'Brien EA, Lin H. Free fluid in Morison's pouch on bedside ultrasound predicts need for operative intervention in suspected ectopic pregnancy. Acad Emerg Med 2007; 14(8): 755-758. http://www.ncbi.nlm.nih.gov/pubmed/17554008
- Moore CL, Molina A, Lin H. Ultrasound in community emergency departments in the United States: access to ultrasound performed by consultants and status of emergency physician performed ultrasound. Ann Emerg Med 2006; 47:147-153. http://www.ncbi.nlm.nih.gov/pubmed/16431225
- Chen L, Hsiao A, Moore CL, Dziura J, Santucci K. Utility of bedside bladder ultrasound before urethral catheterization in young children. Pediatrics 2005; 115: 108-111. http://www.ncbi.nlm.nih.gov/pubmed/15629989
- Monico EB, Moore CL, Calise A. The impact of evidence-based medicine and evolving technology on the standard of care in emergency medicine. J Law Health Ethics 2005; 3(2). http://ispub.com/IJLHE/3/2/12735
- Moore CL, Gregg S, Lambert MJ. Performance, training, quality assurance, and reimbursement of emergency physician-performed ultrasound at academic medical centers. J Ultrasound Med 2004; 23:459-466. http://www.ncbi.nlm.nih.gov/pubmed/15098862
- Moore CL, Promes S. Ultrasound in pregnancy. Emerg Med Clin N Amer 2004;22 (3):697-722. http://www.ncbi.nlm.nih.gov/pubmed/15301847
- Moore CL, Lambert MJ. Emergency ultrasound: diagnosis of deep venous thrombosis. Emerg Med Reports 2003; 24:11-27. http://www.ahcmedia.com/articles/26931-emergency-ultrasound-part-ii-diagnosis-of-deep-venous-thrombosis
- Moore CL, Rose GA, Arrowood JA, Sullivan DM, Tayal VS, Kline JA. Determination of left ventricular function in hypotensive emergency department patients by emergency physician echocardiography. Acad Emerg Med 2002; 9:186-193. http://www.ncbi.nlm.nih.gov/pubmed/11874773
- Cope JT, Mauney MC, Banks D, Binns OA, Moore CL, Rentz JJ, Shockey KS, King RC, Kron IL, Tribble CG. Intravenous phenylephrine preconditioning of cardiac grafts from non-heart-beating donors. Ann Thorac Surg 1997; 63:1664-1668 http://www.ncbi.nlm.nih.gov/pubmed/9205165
- Yuan R, Plurde R, Shoemaker MR, Moore CL, Hanson DE. A mimic of a torsionally-distorted peptide state and the transition state for peptide bond hydrolysis: synthesis of a spiro[4.4]nonyl derivative. J Organ Chem 1995; 60:5360-5364. http://pubs.acs.org/doi/abs/10.1021/jo00121a072