Chiang-Shan Ray Li MD PhD

Associate Professor of Psychiatry and of Neurobiology

Research Interests

Systems neuroscience; Psychophysics; Neural imaging; Cognitive control; Addiction; Psychostimulant; Alcohol; Anxiety disorders

Research Summary

Our research focuses on combining psychophysics, neural imaging, and computation to understand how brain works at the systems level. In particular, we are interested in the neural processes of cognitive control and how deficits in these processes may contribute to the pathogenesis of substance use disorders and other psychiatric conditions. Our research also focuses on the neurochemical basis of cognition. We employ phamacological manipulation and resting state as well task-based brain imaging to examine the catecholaminergic circuits of importance to neuropsychiatric conditions.

Selected Publications

  • Li C-SR, Ide JS, Zhang S, Hu S, Chao HH, Zaborszky L (2014) Resting state functional connectivity of the basal nucleus of Meynert in humans. NeuroImage 97:321-32.
  • Farr OM, Hu S, Matuskey D, Zhang S, , Abdelghany O, Li C-SR (2014). The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults. Exp Clin Neuropsychopharmacol. 22(2):154-65.
  • Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr O, Hong K-I, Sinha R, Mazure CM, Li C-SR (2013) Error processing and gender shared and specific neural predictors of relapse in cocaine dependence. Brain 136: 1231-1244.
  • Hu S, Tseng YC, Winkler A, Li C-SR (2014) Neural bases of individual variation in decision time. Human Brain Mapp. 35(6):2531-42.
  • Ide JS, Shenoy P, Yu AJ, Li C-SR (2013) Bayesian evaluation and prediction in the anterior cingulate cortex. J Neurosci. 33: 2039-47.
  • Zhang S, Ide JS, Li C-SR (2012) Resting state functional connectivity of the medial superior frontal cortex. Cereb Cortex 22: 99-111.
  • Ide JS, Li C-SR (2011) A cerebellar thalamic cortical circuit for error-related cognitive control. NeuroImage 54: 455-464.
  • Li C-SR, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JLK, Rounsaville, BJ, Ding YS, Malison RT (2010) Biological markers of the effects of methylphenidate on improving inhibitory control in cocaine dependent patients. Proc Natl Acad Sci USA. 107: 14455-14459.
  • Duann J-R, Ide S, Luo, X, Li C-SR (2009) Functional connectivity delineates distinct roles of the inferior frontal cortex and pre-supplementary motor area during stop signal inhibition. J Neurosci 29: 10171-10179.
  • Li C-SR, Chao HH-A, Lee TW (2009) The neural correlates of speeded compared to delayed responses in a stop signal task: an indirect analogue of risk taking and association with an anxiety trait. Cereb Cortex 19: 839-848.


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