Asht Mangal Mishra PhD

Research Interests

Abscence Epilepsy; Electrophysiology; Epilepsy; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Neurophysiology

Current Projects

  • Functional MRI and electrophysiology in absence seizures.
  • Resting functional connectivity studies of absence seizures.
  • Diffusion tensor imaging studies of microstructural changes in seizure-prone brain regions in WAG/Rij rat's brain treated with different anti-epilepsy medicines
  • In vivo electrophysiology and fMRI recordings from animal models of epilepsy

Research Summary

Epilepsy research combines my interests in understanding abnormal brain connectivity, and combating human disease. My long term future career plan is to understand the basic neurobiological mechanisms of epilepsy using functional neuroimaging, DTI, electrophysiology, and molecular techniques.

Selected Publications

  • Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased subcortical cholinergic arousal in focal seizures. Neuron. 2015 Feb 4;85(3):561-72. doi: 10.1016/j.neuron.2014.12.058. PubMed PMID: 25654258
  • Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Frohlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H. Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures. Neuroimage. 2015 Apr 1;109:368-77. doi: 10.1016/j.neuroimage.2014.12.066. Epub 2015 Jan 3. PubMed PMID: 25562830
  • Mishra AM, Bai X, Sanganahalli BG, Waxman SG, Shatillo O, Grohn O, Hyder F, Pitkänen A, Blumenfeld H. Decreased resting functional connectivity after traumatic brain injury in the rat. PLoS One. 2014 Apr 18;9(4):e95280. doi: 10.1371/journal.pone.0095280. eCollection 2014. PubMed PMID: 24748279
  • van Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Lüttjohann A, Hyder F, Blumenfeld H, van Rijn CM. Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiol Dis. 2013 Dec;60:126-38. doi: 10.1016/j.nbd.2013.08.013. Epub 2013 Aug 23. PubMed PMID: 23978468
  • Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, Desalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. J Neurosci. 2011 Oct 19;31(42):15053-64. PMID: 22016539
  • Mishra AM, Bai H, Gribizis A, and Blumenfeld H. Neuroimaging biomarkers of epileptogenesis. Neuroscience Letters 2011 Jun 27;497(3):194-204. Epub 2011 Feb 16. PMID: 21303682.
  • Desalvo MN, Schridde U, Mishra AM, Motelow JEM, Purcaro MJ, Hyder F, Blumenfeld H. Focal BOLD-fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. NeuroImage 2010;50(3):902-909.
  • Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. Neuroimage. 2009;47(2):459-466. PMID 19398019.
  • Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H. Cortical deactivation induced by limbic seizures or lateral septal stimulation. Journal of Neuroscience 2009;29(41):13006-18.
  • Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, and Blumenfeld H. Remote effects of focal hippocampal seizures on the rat neocortex. J Neuroscience 2008;28(36):9066-9081. PMID: 18768701


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