Asht Mangal Mishra PhD

Research Interests

Abscence Epilepsy; Electrophysiology; Epilepsy; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Neurophysiology

Current Projects

  • Functional MRI and electrophysiology in absence seizures.
  • Resting functional connectivity studies of absence seizures.
  • Diffusion tensor imaging studies of microstructural changes in seizure-prone brain regions in WAG/Rij rat's brain treated with different anti-epilepsy medicines
  • In vivo electrophysiology and fMRI recordings from animal models of epilepsy

Research Summary

Epilepsy research combines my interests in understanding abnormal brain connectivity, and combating human disease. My long term future career plan is to understand the basic neurobiological mechanisms of epilepsy using functional neuroimaging, DTI, electrophysiology, and molecular techniques.

Selected Publications

  • Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, Desalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. J Neurosci. 2011 Oct 19;31(42):15053-64. PMID: 22016539
  • Mishra AM, Bai H, Gribizis A, and Blumenfeld H. Neuroimaging biomarkers of epileptogenesis. Neuroscience Letters 2011 Jun 27;497(3):194-204. Epub 2011 Feb 16. PMID: 21303682.
  • Desalvo MN, Schridde U, Mishra AM, Motelow JEM, Purcaro MJ, Hyder F, Blumenfeld H. Focal BOLD-fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. NeuroImage 2010;50(3):902-909.
  • Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. Neuroimage. 2009;47(2):459-466. PMID 19398019.
  • Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H. Cortical deactivation induced by limbic seizures or lateral septal stimulation. Journal of Neuroscience 2009;29(41):13006-18.
  • Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, and Blumenfeld H. Remote effects of focal hippocampal seizures on the rat neocortex. J Neuroscience 2008;28(36):9066-9081. PMID: 18768701
  • Ellens DJ, Hong E, Giblin K, Singleton MJ, Bashyal C, Englot DJ, Mishra AM, Blumenfeld H. Development of spike-wave seizures in C3H/HeJ mice. Epilepsy Research 2009; 85(1), pp. 53-59. PMID: 19409755.
  • M Prakash, Gupta RK, Jha D, Mishra AM, Jaggi RS, Husain M. Brain abscess: MRI demonstration of rare cause of intraventricular hemorrhage. Eur J Radiol Extra 2004;51:91-93.
  • Kale RA, Gupta RK, Saraswat VA, Hasan, KM, Trivedi R, Mishra AM, Ranjan P, Pandey CM, Narayana PA. Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy. HEPATOLOGY 2006;43(4):698-706. PMID: 16557540
  • Prasad KN, Mishra AM, Gupta D, Husain N, Husain M, Gupta RK. Analysis of microbial etiology and mortality in patients with brain abscess. J Infect 2006;53(4):221-227. PMID: 16436297


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