Nephrology; Developmental Biology
Our laboratory is currently interested in understanding how G-protein coupled chemokine receptor Cxcr4 modulates kidney development and fibrosis
Extensive Research Description
My laboratory is currently interested in determining what role chemokine receptor Cxcr4 plays in a developing and in an adult kidney. Cxcr4 is a seven-transmembrane G-protein coupled receptor protein known for its co-receptor activity for HIV-I and stem-cell homing. Its role in a developing kidney is only now being studied, partly because the Cxcr4 null mice die in-utero.Our laboratory has recently determined that it is also expressed in epithelial compartments of a developing and adult kidney. We observed that Cxcr4 positively contributes to ureteric-bud branching and may be involved in mesenchymal-to-epithelial transition (MET).
We also determining its potential involvement in the progression of renal fibrosis.
1. Understanding role of chemokine receptor, Cxcr4 in kidney development
2. Role of Cxcr4 in renal fibrosis
3. Determine whether a sub-population of Cxcr4 positive circulating myeloid cells can be used as biomarker for progressive chronic kidney disease
- Anti-fibrosis therapy and diabetic nephropathy. Karihaloo A. Curr Diab Rep. 2012 Aug;12(4):414-22. PMID: 22644874
- Macrophages promote cyst growth in polycystic kidney disease. Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG. J Am Soc Nephrol. 2011 Oct;22(10):1809-14. Epub 2011 Sep 15. PMID: 21921140 [PubMed - in process]
- Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Takiar V, Nishio S, Seo-Mayer P, King JD Jr, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2462-7. Epub 2011 Jan 24.
- Joseph Ueland, Amy Yuan, Arnaud Marlier, Anna-Rachel Gallagher and Anil Karihaloo. A novel role for the chemokine receptor Cxcr4 in kidney morphogenesis, an in-vitro study. Dev Dynamics. 2009; 238 (5): 1083-91
- Marlier A, Schmitt-Ott K, Gallagher AR, Barasch J, Karihaloo A. Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric-bud. Mech Dev. 126 (2009) 91-98
- Anil Karihaloo, Feng Wei, Zhiheng Yu, Arnaud Marlier, Pankaj Seth, Sekiya Shibazaki, Tong Wong, Vikas Sukhatme, Stefan Somlo, and Lloyd G Cantley. Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo.
- Americo E. Esquibies, Alia Bazzy-Asaad, Farshid Ghassemi, Hitoshi Nishio, Anil Karihaloo, and Lloyd G. Cantley. VEGF attenuates hyperoxic injury through decreased apoptosis in explanted rat embryonic lung. Pediatric research. 2008, 63 (1), 20-5.
- Karihaloo A Grimm DH**, Cai Y, Somlo S, Cantley LG, and Caplan MJ. Polycystin-2 regulates proliferation and branching morphogenesis in renal epithelial cells. JBC. 2006, 6; 281(1): 137-44
- Karihaloo A, Karumanchi SA, Cantley WL, Venkatesha S, Cantley LG, and Kale S. VEGF Induces Branching Morphogenesis/Tubulogenesis in Renal Epithelial Cells in a Neuropilin Dependent Fashion. Mol Cell Biol. 2005, 25(17); 7441-8