Americo E Esquibies, MD

Assistant Professor of Pediatrics (Respiratory)

Research Interests

Hypoxia, Brain; Lung; Pediatrics; Respiration; Hyperoxia; Vascular Endothelial Growth Factor A

Research Organizations

Pediatrics: Pediatric Respiratory Medicine

Research Summary

Bronchopulmonary dysplasia (BPD) occurs primarily in preterm infants who require mechanical ventilation and supplemental oxygen. High inspired oxygen levels can cause arrested lung development. My ultimate goal is to design strategies to treat preterm infants who are at risk for BPD in a manner that promotes normal lung development in the face of therapeutic interventions including supplemental oxygen.

Specialized Terms: Hypoxia; Lung development; VEGF; Hyperoxia; Prostaglandin D synthase

Extensive Research Description

The goal of our research is to understand the cellular and molecular mechanisms that underlie hyperoxic injury, and to identify potential protective mechanisms in the developing lung. Defining these mechanisms will set the stage for our long term goal of fully understanding the injury and repair process in the developing lung and the development of therapeutic strategies for the prevention and/or reversal of these processes. Specific VEGF isoform mice ( i.e. VEGF188+/+) are an important tool to elucidate the specific role of each isoform during lung development and hyperoxia. Preliminary work showed that VEGF 165 partly attenuates lung growth retardation and since VEGF 188 is expressed in greater amounts than VEGF 165, we speculate that VEGF 188 plays a major protective role against hyperoxic injury and also preventing lung growth failure

Selected Publications

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Contact Info

Americo E Esquibies, MD
Patient Care Locations
Yale Pediatric Respiratory Medicine Hospital for Special Care
2150 Corbin Avenue, Ste Pediatric Unit

New Britain, CT 06053
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Yale Pediatric Specialty Center - Long Wharf1 Long Wharf Drive, Ste 210
New Haven, CT 06511
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Yale Pediatric Respiratory MedicineYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion, 2nd Floor

New Haven, CT 06504
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Office Location
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 511

New Haven, CT 06519
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Mailing Address
PO Box 208064
FMP 511

New Haven, CT 06520-8064

Curriculum Vitae