Alan Dardik MD-PhD, FACS, FAHA

Professor of Surgery (Vascular); Chief, Vascular Surgery, VA Connecticut Healthcare Systems, West Haven, CT

Biographical Info

Dr. Alan Dardik is a surgeon-scientist who seeks to use the power of molecular biology to achieve a modern understanding of vascular disease, and to use the basic science laboratory to perform cutting edge research to ultimately benefit patients with vascular disease. Dr. Dardik trained at Yale, the University of Pennsylvania, and the Johns Hopkins Hospital before his appointment to the Yale faculty in 2001. Dr. Dardik concentrates his clinical practice in vascular surgery at the VA Connecticut where he is the Chief of the Vascular Surgery section, focusing his practice on teaching of medical students, residents, and fellows.

Dr. Dardik is currently the Vice-President of the International Society for Vascular Surgery and the Recorder for the Association of VA Surgeons.

The Dardik laboratory studies the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular bypass surgery. We are currently trying to understand the fundamental molecular mechanisms by which vein graft adaptation results in positive remodeling and successful adaptation to the arterial environment, yet often proceeds, in the long-term, to neointimal hyperplasia and graft failure. The laboratory has made the original observation that vein graft adaptation is associated with diminished Eph-B4 expression (Kudo et al., ATVB 27:1562, 2007). We are currently investigating the importance of modulating Eph-B4 function in vein graft adaptation, and have recently published that Eph-B4 is active in adult veins, regulates venous remodeling, and that Eph-B4 function depends on receptor phosphorylation and association with caveolin-1 signaling (Muto et al., J Exp Med 208:561, 2011).

The laboratory is funded from the NIH, the VA, as well as from the Yale Department of Surgery Ohse award. As part of Yale's Vascular Biology and Therapeutics program, the lab is located on the 4th floor of the Amistad building. Members of the Dardik laboratory include surgery residents from Yale and other programs as well as postdoctoral fellows and students from Japan, China, Lebanon and France.


International Activity

  • Invited Lecture, Controversies & Updates in Vascular Surgery 2014
    Paris, France(2014 - 2014)
    CEA: What is the current best patch if any? CEA. Quel est le meilleur patch (s’il existe) ?
  • Visiting Professor lecture, University of Milan
    Milano, Italy(2014 - 2014)
    Changing veins into arteries: How does Eph-B4 regulate vessel identity?
  • Faculty organizer, ISVS 2014 China meeting
    Guangzhou, China(2014 - 2014)
    Faculty organizer of the International Society for Vascular Surgery meeting in Guangzhou, China.
  • Vice President, International Society for Vascular Surgery
    United States(2013)
    The mission of the International Society for Vascular Surgery is: To educate other healthcare professionals, government agencies and the general public concerning the unique services and valuable benefits provided by Vascular Surgery practitioners who are well trained and committed to the specialty in all its nuances. To identify and provide recognition to individuals who meet certain guidelines, which qualify them as, committed and accomplished vascular surgeons. To provide scholarships, travel, poster and abstract awards to fellows in training, in an effort to improve the delivery of care in their respective country.
  • Visiting Professor lecture, Surgical Grand Rounds, Royal National Orthopaedic Hospital, University College of London
    Stanmore, United Kingdom(2013 - 2013)
    What do animal models of ischemia teach us about therapeutic angiogenesis?
  • Visiting Professor lecture, Surgical Grand Rounds, Universidade Federal de Minas Gerais
    Belo Horizonte, Brazil(2013 - 2013)
    Preoperative Management of the Surgical Patient
  • Visiting Professor lecture, Department of Vascular Surgery, Hôpital St. Roch, University of Nice
    Nice, France(2013 - 2013)
    Changing veins into arteries: How does Eph-B4 regulate vessel identity?
  • Visiting Professor lecture, Sun-Yat Sen University School of Medicine
    Guangzhou, China(2013 - 2013)
    Do surgeons turn veins into arteries?
  • Invited lectures, 1st annual Chinese Chapter Congress of the International Union of Angiology
    Beijing, China(2013 - 2013)
    1) Advanced Age and Disease Predict Lack of Satisfaction After Iliac Stent Placement. 2) Factors for consideration for endovascular repair of aortic dissections: A Yale University perspective. 3) Current trends in the treatment of diabetic foot in America (associated Diabetic Foot Symposium).
  • Visiting Professor, XuanWu Hospital, Capital Medical University
    Beijing, China(2013 - 2013)
    Visiting Professor lectures, performance of surgical cases in the operating room.
  • Invited lectures, 40th annual meeting of the Japanese Society of Vascular Surgery
    Nagano-shi, Japan(2012 - 2012)
    1) Endovascular Therapy by vascular surgeons in USA. 2) Therapy for PAD: Strategies by Vascular Surgeons in the USA
  • Invited Lectures, 12th annual meeting of the Encontro Mineiro De Angiologia e Cirurgia Vascular
    Belo Horizonte, Brazil(2012 - 2012)
    1) Behavior of venous grafts and pericardial patches after surgery. 2) Is endovascular treatment the first choice for all patients with PAD? Is there still a role for open surgery? 3) Is it possible to treat TASC D lesions with endovascular techniques? 4) Management of carotid stenosis: What is best, CEA CAS or medical therapy? What do the randomized studies say?
  • Invited lecture, 11th annual Yale-Cambridge Joint Research Program
    Cambridge, United Kingdom(2012 - 2012)
    Understanding vein adaptation to the arterial environment
  • Invited lectures, 11th annual China National Congress of Vascular Surgery
    Changsha, China(2012 - 2012)
    1) How do pericardial patches heal after surgery? 2) Durability considerations for EVAR : selection choices and long term outcomes. 3) Factors for Consideration for Endovascular repair of aortic dissections: a Yale University perspective
  • Invited Lecture, Controversies & Updates in Vascular Surgery 2011
    Paris, France(2011 - 2011)
    Does a high risk patient for carotid endarterectomy (CEA) exist? / Y-a-t-il des patients à haut risque pour une endartériectomie carotidienne (EAC)
  • Keynote Speaker, 4th China national symposium on vascular disease
    Changsha, China(2011 - 2011)
    New Research on the Etiology of Abdominal Aortic Aneurysms
  • Visiting Professor lecture, Royal Free Hospital
    London, United Kingdom(2011 - 2011)
    Can surgeons turn veins into arteries?
  • Invited lecture - The Litchfield Lecturership
    Oxford, United Kingdom(2011 - 2011)
    Can we turn veins into arteries?
  • Visiting professor lecture, Leeds General Infirmary
    Leeds, United Kingdom(2011 - 2011)
    Healing of vascular grafts and patches: Lessons for tissue engineers
  • Invited lecture, Controversies & Updates in Vascular Surgery 2010
    Paris, France(2010 - 2010)
    La veine peut-elle devenir une artère? Do vein grafts arterialize?
  • Keynote Address, 11th annual congress of the Asian Society for Vascular Surgery
    Kyoto, Japan(2010 - 2010)
    The Future of Bypass Surgery: Lessons from the Embryo
  • Invited Lecture, 9th annual Yale-Cambridge Joint Research Program
    Cambridge, United Kingdom(2010 - 2010)
    Understanding Eph-B4 Control of Vein Graft Adaptation
  • Invited Lectures, CIPRAME (International Conference of Medical Practices) Cardiovascular Disease
    Belo Horizonte, Brazil(2010 - 2010)
    1) Peripheral arterial disease: Diagnosis and Treatment. 2) Cerebrovascular disease: Diagnosis and Treatment
  • Invited lectures, 7th annual Western Vascular Institute Symposium
    Gaillimh, Ireland(2009 - 2009)
    1) Regulation of vessel identity during vein graft adaptation – Are we closer to preventing neointimal hyperplasia?” 2) What’s Happening With Stem Cell Treatments For Lower Limb Ischemia?
  • Invited lecture, 6th annual Western Vascular Institute Symposium
    Gaillimh, Ireland(2008 - 2008)
    Regulation of vessel identity during vein graft adaptation
  • Vascular Biology
    China(2008)
    This program is a collaboration between Yale faculty (Dr Alan Dardik) and Central-South University (Dr Chang Shu), encouraging the study of vascular biology. Both basic science (Yale campus) investigations as well as clinical (China campus) investigations are performed.
  • Vascular Biology
    Tokyo, Japan(2007)
    This program is a collaboration between Yale faculty (Dr Alan Dardik) and Tokyo Medical University (Dr Toshiya Nishibe), encouraging the study of blood vessels and blood vessel substitutes as used in vascular surgery. Both basic science (Yale campus) investigations as well as clinical (Japan campus) investigations are performed.
  • Invited lecture, 35th Annual Meeting of Japanese Society for Vascular Surgery
    Nagoya-shi, Japan(2007 - 2007)
    Peripheral bypass strategy for infrainguinal vascular disease
  • Keynote address, 35th Annual Meeting of Japanese Society for Vascular Surgery
    Nagoya-shi, Japan(2007 - 2007)
    Venous identity is lost but arterial identity is not gained during vein graft adaptation
  • Invited lecture, Tokyo Medical and Dental University
    Tokyo, Japan(2006 - 2006)
    U.S. update report: Carotid endarterectomy vs. carotid artery stenting
  • Invited lecture, 13th Annual National Conference of the Vascular Society of India
    New Delhi, India(2006 - 2006)
    Carotid endarterectomy: community gold standard for high risk patients
  • Invited lecture, Fujita Health University
    Nagoya-shi, Japan(2005 - 2005)
    Effects of aging on vascular healing
  • Invited lecture, The John Radcliffe Hospital, Oxford University
    Oxford, United Kingdom(1999 - 1999)
    How to build a better blood vessel

Education & Training

B.S.
Yale University, New Haven, CT (1986)
M.D./Ph.D.
University of Pennsylvania (1993)
Resident
The Johns Hopkins Hospital, Baltimore, MD, General Surgery (1993 - 1999)
Postdoctoral Fellow
The Johns Hopkins Hospital, Baltimore, MD, General Surgery (1995 - 1997)
Specialist Registrar
The John Radcliffe Hospital, Oxford, UK, Surgery
Chief Resident
The Johns Hopkins Hospital, Baltimore, MD, General Surgery (1999 - 2000)
Fellow
The Johns Hopkins Hospital, Baltimore, MD, Vascular Surgery (2000 - 2001)

Honors & Recognition

  • Valedictorian
    The Frisch School, Paramus, NJ (1982)
  • Phi Beta Kappa
    Yale University, New Haven, CT (1984)
  • Tau Beta Pi
    Yale University, New Haven, CT (1985)
  • Summa Cum Laude
    Yale University, New Haven, CT (1986)
  • Keynote speaker, 35th annual meeting; Nagoya, Japan
    Japanese Society for Vascular Surgery (2007)
  • Keynote Speaker, 11th annual congress; Kyoto, Japan
    Asian Society for Vascular Surgery (2010)
  • Keynote Speaker, 4th annual meeting; Changsha, China
    Chinese National Symposium on Vascular Disease (2011)
  • Distinction in the Major, Computer Science
    Yale University, New Haven, CT (1986)
  • The Litchfield Lecturership
    Oxford University, Oxford, UK (2011)
  • William D Carey Science Award (for an outstanding graduate student in science and engineering)
    American Association for the Advancement of Science (1991)
  • Keynote speaker, 12th annual meeting; Belo Horizonte, Brazil
    Encontro Mineiro De Angiologia e Cirurgia Vascular, Brazil (2012)
  • Balduin Lucke Memorial Prize (for superior research in experimental medicine and biology)
    University of Pennsylvania School of Medicine, Philadelphia, PA (1992)
  • Keynote Speaker; 11th annual China National Congress of Vascular Surgery, Changsha, China
    Chinese Society for Vascular Surgery (2012)
  • Sandoz Surgical Student Research Award (for superior accomplishment in biomedical research)
    Association for Academic Surgery (1993)
  • International Vascular Biology Travel Award
    North American Vascular Biology Organization (2002)
  • Franklin Martin Faculty Research Fellowship (highest ranking faculty research proposal)
    American College of Surgeons (2002)
  • Upjohn Award for Clinical Research (for outstanding clinical research by a resident member of the Department of Surgery)
    Johns Hopkins University Department of Surgery, Baltimore, MD (1996)
  • Surgical Resident and Fellows Award
    Baltimore Academy of Surgery, Baltimore, MD (1997)
  • Upjohn Award for Clinical Research
    Johns Hopkins University Department of Surgery, Baltimore, MD (1997)
  • First Place, Fellow and Resident Paper Competition
    Chesapeake Vascular Society, Annapolis, MD (2000)
  • E.J.Wylie Traveling Fellowship
    Lifeline Foundation (2002)
  • Dennis Jahnigen Career Development Scholar Award
    American Geriatrics Society (2002)
  • Wylie Scholar in Academic Vascular Surgery Award
    Pacific Vascular Research Foundation (2002)
  • Faculty Teaching Award
    Surgical Residents of St Mary’s Hospital, Waterbury, CT (2002)
  • The William J. von Liebig Vascular Academic Award
    Peripheral Vascular Surgery Society (2004)
  • Faculty Teaching Award
    Surgical Residents of St Mary’s Hospital, Waterbury, CT (2004)
  • Honorable Mention, C. Elton Cahow Award for Outstanding Faculty Teaching
    Department of Surgery, Yale University School of Medicine, New Haven, CT (2005)
  • American College of Surgeons Traveling Fellowship to Japan
    American College of Surgeons (2006)
  • The William J. von Liebig Award (highest ranking vascular surgery basic science research proposal)
    Lifeline Foundation/American Vascular Association (2006)
  • C. Elton Cahow Award for Outstanding Faculty Teaching
    Department of Surgery, Yale University School of Medicine, New Haven, CT (2006)
  • Distinguished Fellowship
    Society for Vascular Surgery (2007)
  • Fellow (FAHA)
    American Heart Association (2014)

Professional Service

  • Vice-President, International Society for Vascular Surgery (7/1/2013)
  • Research Council, Society for Vascular Surgery (7/1/2013)
  • Councilor, Class of 2002, Association for Academic Surgery (7/1/2010 - 6/30/2012)
  • Treasurer, International Society for Vascular Surgery (7/1/2009 - 6/30/2012)
  • Representative to the Advisory Council for Vascular Surgery, American College of Surgeons, Peripheral Vascular Surgery Society (7/1/2006 - 6/30/2012)
  • Regional Councilor - North America, International Society for Vascular Surgery (7/1/2005 - 6/30/2008)
  • Recorder, Association of VA Surgeons (4/1/2014)
  • Research Committee, Association of VA Surgeons (2009 - 2012)
  • Grant reviewer for VCMB study section, challenge grants, NIH NHLBI (2009 - 2009)
  • Program Committee, Chairman, Association of VA Surgeons (2008 - 2009)
  • Awards Committee, New England Society for Vascular Surgery (2008)
  • Program Committee, Peripheral Vascular Surgery Society (2008 - 2008)
  • Program Committee, Section for Surgical and Related Medical Specialties, American Geriatrics Society (2007 - 2009)
  • Program Committee, Association for Academic Surgery (2007 - 2009)
  • Advisory Council for Vascular Surgery, American College of Surgeons (2006)
  • Issues Committee, Eastern Vascular Society (2006 - 2010)
  • Constitution and By-Laws Committee, Society for Clinical Vascular Surgery (2006 - 2009)
  • Institutional Representative, Association for Academic Surgery (2005 - 2007)
  • Program Committee, Association of VA Surgeons (2005 - 2009)
  • Young Vascular Surgeons Committee, Eastern Vascular Society (2005)
  • Program Committee, New England Society for Vascular Surgery (2004 - 2009)
  • Membership Committee, Peripheral Vascular Surgery Society (2004 - 2004)
  • Informatics and Technology Committee, Association for Academic Surgery (2003 - 2005)
  • Program Committee, Chairman, Peripheral Vascular Surgery Society (2003 - 2004)
  • Chair for SURG 1 study section, VA (11/01/2011 - 12/31/2012)
  • Grant reviewer for SURG 1 study section, VA (1/1/2010 - 12/31/2012)
  • Associate Editor, Journal of Surgical Research (07/01/2013)
  • Chair, Research and Education Committee, Society for Vascular Surgery (07/01/2009 - 06/30/2013)
  • Vascular Cures (Pacific Vascular Research Foundation) (07/01/2007)
  • Research and Education Committee, Chairman, Society for Vascular Surgery (06/01/2009 - 05/30/2013)
  • Program Committee, Society for Vascular Surgery (06/01/2009 - 05/30/2013)
  • Research and Education Committee, Society for Vascular Surgery (06/01/2006 - 05/30/2013)
  • BTSS study section, NIH NHLBI (01/01/2012)
  • Program Committee, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Spring Conference, American Heart Association (01/01/2009 - 04/30/2013)
  • Editorial Board, Vascular (01/01/2007)
  • Editorial Board, Annals of Vascular Surgery (01/01/2007)
  • Editorial Board, Journal of Vascular Surgery (01/01/2006 - 12/31/2012)

Edit Profile