Alan Dardik, MD/PhD, FACS, FAHA

Professor of Surgery (Vascular); Chief, Vascular Surgery, VA Connecticut Healthcare Systems, West Haven, CT

Departments & Organizations

NIH T32 Program

Office of Student Research

Surgery: Vascular Surgery

Vascular Biology and Therapeutics Program: Dardik Lab

Biography

Dr. Alan Dardik is a surgeon-scientist who seeks to use the power of molecular biology to achieve a modern understanding of vascular disease, and to use the basic science laboratory to perform cutting edge research to ultimately benefit patients with vascular disease. Dr. Dardik trained at Yale, the University of Pennsylvania, and the Johns Hopkins Hospital before his appointment to the Yale faculty in 2001. Dr. Dardik concentrates his clinical practice in vascular surgery at the VA Connecticut where he is the Chief of the Vascular Surgery section, focusing his practice on teaching of medical students, residents, and fellows.

Dr. Dardik is currently the President of the International Society for Vascular Surgery and the Recorder for the Association of VA Surgeons.

The Dardik laboratory studies the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular bypass surgery. We are currently trying to understand the fundamental molecular mechanisms by which vein graft adaptation results in positive remodeling and successful adaptation to the arterial environment, yet often proceeds, in the long-term, to neointimal hyperplasia and graft failure. The laboratory has made the original observation that vein graft adaptation is associated with diminished Eph-B4 expression (Kudo et al., ATVB 27:1562, 2007). We are currently investigating the importance of modulating Eph-B4 function in vein graft adaptation, and have recently published that Eph-B4 is active in adult veins, regulates venous remodeling, and that Eph-B4 function depends on receptor phosphorylation and association with caveolin-1 signaling (Muto et al., J Exp Med 208:561, 2011).

The laboratory is funded from the NIH, the VA, as well as from the Yale Department of Surgery Ohse award. As part of Yale's Vascular Biology and Therapeutics program, the lab is located on the 4th floor of the Amistad building. Members of the Dardik laboratory include surgery residents from Yale and other programs as well as postdoctoral fellows and students from around the world.

Education & Training

MD/PhD University of Pennsylvania (1993)
BS Yale University, New Haven, CT, Computer Science (1986)
Fellow The Johns Hopkins Hospital
Chief Resident The Johns Hopkins Hospital
Postdoctoral Fellow (NIH F32) Johns Hopkins University
Resident The Johns Hopkins Hospital
Specialist Registrar The John Radcliffe Hospital

Honors & Recognition

  • Keynote speaker; European Society for Vascular Surgery Spring meeting; Frankfurt, GermanyEuropean Society for Vascular Surgery (2015)

  • FellowAmerican Surgical Association (2015)

  • Master of Arts Degree (honorary)Yale University, New Haven, CT (2015)

  • Fellow (FAHA)American Heart Association (2014)

  • Keynote Speaker; 11th annual China National Congress of Vascular Surgery, Changsha, ChinaChinese Society for Vascular Surgery (2012)

  • Keynote speaker, 12th annual meeting; Belo Horizonte, BrazilEncontro Mineiro De Angiologia e Cirurgia Vascular, Brazil (2012)

  • The Litchfield LecturershipOxford University, Oxford, UK (2011)

  • Keynote Speaker, 4th annual meeting; Changsha, ChinaChinese National Symposium on Vascular Disease (2011)

  • Keynote Speaker, 11th annual congress; Kyoto, JapanAsian Society for Vascular Surgery (2010)

  • Distinguished FellowshipSociety for Vascular Surgery (2007)

  • Keynote speaker, 35th annual meeting; Nagoya, Japan Japanese Society for Vascular Surgery (2007)

  • American College of Surgeons Traveling Fellowship to JapanAmerican College of Surgeons (2006)

  • The William J. von Liebig Award (highest ranking vascular surgery basic science research proposal)Lifeline Foundation/American Vascular Association (2006)

  • C. Elton Cahow Award for Outstanding Faculty TeachingDepartment of Surgery, Yale University School of Medicine, New Haven, CT (2006)

  • Honorable Mention, C. Elton Cahow Award for Outstanding Faculty TeachingDepartment of Surgery, Yale University School of Medicine, New Haven, CT (2005)

  • The William J. von Liebig Vascular Academic AwardPeripheral Vascular Surgery Society (2004)

  • Faculty Teaching AwardSurgical Residents of St Mary’s Hospital, Waterbury, CT (2004)

  • Franklin Martin Faculty Research Fellowship (highest ranking faculty research proposal)American College of Surgeons (2002)

  • International Vascular Biology Travel AwardNorth American Vascular Biology Organization (2002)

  • E.J.Wylie Traveling FellowshipLifeline Foundation (2002)

  • Dennis Jahnigen Career Development Scholar AwardAmerican Geriatrics Society (2002)

  • Wylie Scholar in Academic Vascular Surgery AwardPacific Vascular Research Foundation (2002)

  • Faculty Teaching Award Surgical Residents of St Mary’s Hospital, Waterbury, CT (2002)

  • First Place, Fellow and Resident Paper Competition Chesapeake Vascular Society, Annapolis, MD (2000)

  • Surgical Resident and Fellows AwardBaltimore Academy of Surgery, Baltimore, MD (1997)

  • Upjohn Award for Clinical ResearchJohns Hopkins University Department of Surgery, Baltimore, MD (1997)

  • Upjohn Award for Clinical Research (for outstanding clinical research by a resident member of the Department of Surgery) Johns Hopkins University Department of Surgery, Baltimore, MD (1996)

  • Sandoz Surgical Student Research Award (for superior accomplishment in biomedical research) Association for Academic Surgery (1993)

  • Balduin Lucke Memorial Prize (for superior research in experimental medicine and biology) University of Pennsylvania School of Medicine, Philadelphia, PA (1992)

  • William D Carey Science Award (for an outstanding graduate student in science and engineering)American Association for the Advancement of Science (1991)

  • Summa Cum LaudeYale University, New Haven, CT (1986)

  • Distinction in the Major, Computer ScienceYale University, New Haven, CT (1986)

  • Tau Beta PiYale University, New Haven, CT (1985)

  • Phi Beta KappaYale University, New Haven, CT (1984)

  • ValedictorianThe Frisch School, Paramus, NJ (1982)

Professional Service

  • Advisory Council for Vascular Surgery 2009 - , Liaison to the ACS Program Committee American College of Surgeons (2006)

  • Program Committee, Section for Surgical and Related Medical Specialties American Geriatrics Society (2007 - 2009)

  • Program Committee, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Spring Conference American Heart Association (2009 - 2013)

  • Informatics and Technology Committee Association for Academic Surgery (2003 - 2005)

  • Executive Committee; Councilor, Class of 2002 Association for Academic Surgery (2010 - 2012)

  • Program Committee Association for Academic Surgery (2007 - 2009)

  • Program Committee Association of VA Surgeons (2005 - 2009)

  • Local arrangements committee, Chairman Association of VA Surgeons (2013 - 2014)

  • Research Committee Association of VA Surgeons (2009 - 2012)

  • Young Vascular Surgeons Committee Eastern Vascular Society (2005 - 2009)

  • Issues Committee Chairman 2009-2010 Eastern Vascular Society (2006 - 2010)

  • Research and Education Committee; Chairman 2009-2013 Society for Vascular Surgery (2006 - 2013)

  • Program Committee New England Society for Vascular Surgery (2004 - 2009)

  • Executive Committee, Councilor-At-Large New England Society for Vascular Surgery (2008 - 2014)

  • Program Committee, Chairman Peripheral Vascular Surgery Society (2003 - 2004)

  • Membership Committee Peripheral Vascular Surgery Society (2004 - 2004)

  • Research Council; Chairman 2015 - Society for Vascular Surgery (2013)

  • Chair, Surgical Case and Other Invasive Procedure (SOIP) Committee VA Connecticut Healthcare Systems, West Haven, CT (2001)

  • Preservation-Amputation Care and Treatment (PACT) Committee VA Connecticut Healthcare Systems, West Haven, CT (2005)

  • Compensation and Pay Committee VA Connecticut Healthcare Systems, West Haven, CT (2006)

  • Senior Faculty Allotment Committee Yale University School of Medicine (2013)

  • Program Committee Society for Vascular Surgery (2009 - 2013)

  • review internal grant applications for the Ohse awards Yale University School of Medicine, Dept of Surgery (2014)

  • Associate Editor Journal of Surgical Research (2013)

  • Editorial Board Journal of Vascular Surgery (2006 - 2012)

  • Editorial Board Vascular (2007)

  • Editorial Board Annals of Vascular Surgery (2007)

  • VCMB study section NIH NHLBI (2009 - 2009)

  • VA Merit Study section; Chair 2011-2012 VA (2010 - 2012)

  • NIH NHLBI Institutional Training Mechanism (NITM) Review Committee NIH NHLBI (2012)

  • Wylie Scholar Award Committee Vascular Cures (Pacific Vascular Research Foundation) (2007)

  • Chair, study section for K08/K23/Wylie traveling/resident/student grants and awards Society for Vascular Surgery (2009 - 2013)

  • Vice-President International Society for Vascular Surgery (2013 - 2014)

  • Regional Councilor - North America International Society for Vascular Surgery (2005 - 2008)

  • Treasurer International Society for Vascular Surgery (2009 - 2013)

  • Executive Committee; Councilor, Class of 2002 Association for Academic Surgery (2010 - 2012)

  • Recorder Association of VA Surgeons (2014)

  • President International Society for Vascular Surgery (2014)

  • Society Representative to the American College of Surgeons Advisory Council for Vascular Surgery Peripheral Vascular Surgery Society (2006 - 2012)

  • Chair of SVS R&E Committee; Faculty Chairman and Course Director of Vascular Research Initiatives Conference (VRIC); Chair, K08/K23/Wylie traveling awards committee Society for Vascular Surgery (2009 - 2013)

International Activity

  • Keynote lecture, European Society for Vascular Surgery spring meeting Frankfurt am Main, Germany (2015 - 2015)

    Surgical alchemy: Do surgeons turn veins into arteries?

  • Invited Lecture, Controversies & Updates in Vascular Surgery 2014 Paris, France (2014 - 2014)

    CEA: What is the current best patch if any? CEA. Quel est le meilleur patch (s’il existe) ?

  • Visiting Professor lecture, University of Milan Milano, Italy (2014 - 2014)

    Changing veins into arteries: How does Eph-B4 regulate vessel identity?

  • President, International Society for Vascular Surgery United States (2014)

    The mission of the International Society for Vascular Surgery is: To educate other healthcare professionals, government agencies and the general public concerning the unique services and valuable benefits provided by Vascular Surgery practitioners who are well trained and committed to the specialty...

  • Faculty organizer, ISVS 2014 China meeting Guangzhou, China (2014 - 2014)

    Faculty organizer of the International Society for Vascular Surgery meeting in Guangzhou, China.

  • Invited lecture, Institute of Biomedical Engineering, University College of London London, United Kingdom (2014 - 2014)

    Hypoxia-activated mesenchymal stem cells: A novel therapy for diabetic wounds

  • Visiting Professor lecture, Surgical Grand Rounds, Royal National Orthopaedic Hospital, University College of London Stanmore, United Kingdom (2013 - 2013)

    What do animal models of ischemia teach us about therapeutic angiogenesis?

  • Visiting Professor lecture, Surgical Grand Rounds, Universidade Federal de Minas Gerais Belo Horizonte, Brazil (2013 - 2013)

    Preoperative Management of the Surgical Patient

  • Visiting Professor lecture, Department of Vascular Surgery, Hôpital St. Roch, University of Nice Nice, France (2013 - 2013)

    Changing veins into arteries: How does Eph-B4 regulate vessel identity?

  • Visiting Professor lecture, Sun-Yat Sen University School of Medicine Guangzhou, China (2013 - 2013)

    Do surgeons turn veins into arteries?

  • Invited lectures, 1st annual Chinese Chapter Congress of the International Union of Angiology Beijing, China (2013 - 2013)

    1) Advanced Age and Disease Predict Lack of Satisfaction After Iliac Stent Placement. 2) Factors for consideration for endovascular repair of aortic dissections: A Yale University perspective. 3) Current trends in the treatment of diabetic foot in America (associated Diabetic Foot Symposium).

    ... ...

  • Visiting Professor, XuanWu Hospital, Capital Medical University Beijing, China (2013 - 2013)

    Visiting Professor lectures, performance of surgical cases in the operating room.

  • Invited lectures, 40th annual meeting of the Japanese Society of Vascular Surgery Nagano-shi, Japan (2012 - 2012)

    1) Endovascular Therapy by vascular surgeons in USA. 2) Therapy for PAD: Strategies by Vascular Surgeons in the USA

  • Invited Lectures, 12th annual meeting of the Encontro Mineiro De Angiologia e Cirurgia Vascular Belo Horizonte, Brazil (2012 - 2012)

    1) Behavior of venous grafts and pericardial patches after surgery. 2) Is endovascular treatment the first choice for all patients with PAD? Is there still a role for open surgery? 3) Is it possible to treat TASC D lesions with endovascular techniques? 4) Management of carotid stenosis: What is...

  • Invited lecture, 11th annual Yale-Cambridge Joint Research Program Cambridge, United Kingdom (2012 - 2012)

    Understanding vein adaptation to the arterial environment

  • Invited lectures, 11th annual China National Congress of Vascular Surgery Changsha, China (2012 - 2012)

    1) How do pericardial patches heal after surgery? 2) Durability considerations for EVAR : selection choices and long term outcomes. 3) Factors for Consideration for Endovascular repair of aortic dissections: a Yale University perspective

  • Modern Alchemy: Turning veins into arteries Oxford, United Kingdom (2011 - 2011)

  • Invited Lecture, Controversies & Updates in Vascular Surgery 2011 Paris, France (2011 - 2011)

    Does a high risk patient for carotid endarterectomy (CEA) exist? / Y-a-t-il des patients à haut risque pour une endartériectomie carotidienne (EAC)

  • Keynote Speaker, 4th China national symposium on vascular disease Changsha, China (2011 - 2011)

    New Research on the Etiology of Abdominal Aortic Aneurysms

  • Visiting Professor lecture, Royal Free Hospital London, United Kingdom (2011 - 2011)

    Can surgeons turn veins into arteries?

  • Invited lecture - The Litchfield Lecturership Oxford, United Kingdom (2011 - 2011)

    Can we turn veins into arteries?

  • Visiting professor lecture, Leeds General Infirmary Leeds, United Kingdom (2011 - 2011)

    Healing of vascular grafts and patches: Lessons for tissue engineers

  • Invited lecture, Controversies & Updates in Vascular Surgery 2010 Paris, France (2010 - 2010)

    La veine peut-elle devenir une artère? Do vein grafts arterialize?

  • Keynote Address, 11th annual congress of the Asian Society for Vascular Surgery Kyoto, Japan (2010 - 2010)

    The Future of Bypass Surgery: Lessons from the Embryo

  • Invited Lecture, 9th annual Yale-Cambridge Joint Research Program Cambridge, United Kingdom (2010 - 2010)

    Understanding Eph-B4 Control of Vein Graft Adaptation

  • Invited Lectures, CIPRAME (International Conference of Medical Practices) Cardiovascular Disease Belo Horizonte, Brazil (2010 - 2010)

    1) Peripheral arterial disease: Diagnosis and Treatment. 2) Cerebrovascular disease: Diagnosis and Treatment

  • Invited lectures, 7th annual Western Vascular Institute Symposium Gaillimh, Ireland (2009 - 2009)

    1) Regulation of vessel identity during vein graft adaptation – Are we closer to preventing neointimal hyperplasia?” 2) What’s Happening With Stem Cell Treatments For Lower Limb Ischemia?

  • Invited lecture, 6th annual Western Vascular Institute Symposium Gaillimh, Ireland (2008 - 2008)

    Regulation of vessel identity during vein graft adaptation

  • Vascular Biology China (2008)

    This program is a collaboration between Yale faculty (Dr Alan Dardik) and Central-South University (Dr Chang Shu), encouraging the study of vascular biology. Both basic science (Yale campus) investigations as well as clinical (China campus) investigations are performed.

  • Invited lecture, 35th Annual Meeting of Japanese Society for Vascular Surgery Nagoya-shi, Japan (2007 - 2007)

    Peripheral bypass strategy for infrainguinal vascular disease

  • Keynote address, 35th Annual Meeting of Japanese Society for Vascular Surgery Nagoya-shi, Japan (2007 - 2007)

    Venous identity is lost but arterial identity is not gained during vein graft adaptation

  • Vascular Biology Tokyo, Japan (2007)

    This program is a collaboration between Yale faculty (Dr Alan Dardik) and Tokyo Medical University (Dr Toshiya Nishibe), encouraging the study of blood vessels and blood vessel substitutes as used in vascular surgery. Both basic science (Yale campus) investigations as well as clinical (Japan...

  • Invited lecture, Tokyo Medical and Dental University Tokyo, Japan (2006 - 2006)

    U.S. update report: Carotid endarterectomy vs. carotid artery stenting

  • Invited lecture, 13th Annual National Conference of the Vascular Society of India New Delhi, India (2006 - 2006)

    Carotid endarterectomy: community gold standard for high risk patients

  • Invited lecture, Fujita Health University Nagoya-shi, Japan (2005 - 2005)

    Effects of aging on vascular healing

  • Invited lecture, The John Radcliffe Hospital, Oxford University Oxford, United Kingdom (1999 - 1999)

    How to build a better blood vessel

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Contact Info

Alan Dardik, MD/PhD, FACS, FAHA
Patient Care Location
Department of SurgeryVA Connecticut Healthcare
950 Campbell Avenue, Ste Bldg 1, Room 4-220

West Haven, CT 06516
Lab Location
Yale School of Medicine - Dardik LabAmistad Street Building
10 Amistad Street, Ste Room 414

New Haven, CT 06519
Office Location
Yale School of Medicine - Vascular Biology and TherapeuticsAmistad Street Building
10 Amistad Street, Ste Room 437

New Haven, CT 06519
Mailing Address
Yale University School of MedicineVascular Biology and Therapeutics
10 Amistad Street; PO Box 208089

New Haven, CT 06520-8089

Curriculum Vitae

Dardik laboratory