The departments and sections encompassed by the YCCMD have well-established records of attracting junior faculty who are bright, young scientists with excellent potential for developing into established investigators in the field of musculoskeletal disease. The primary purpose of the Pilot and Feasibility Program will be to provide these junior faculty members with start-up funds to establish their programs of investigation. In addition to supporting new investigators, the Program is also designed to support established members of the YCCMD who wish to test new ideas related to the research focus of the Core, but not directly related to their current research focus. The Pilot and Feasibility program supports the investigation of animal or cellular models of musculoskeletal disorders. It will not support human clinical studies.