Featured Investigator and Recipient of a Pilot and Feasibility Project Award
Gang-Qing Yao, M.D. is an Associate Research Scientist in the Section of Comparative Medicine. He received his MD degree from Shangdong Academy of Medical Sciences, China in 1984. After completing training in Oncology and Virology at the Cancer Institute of the Chinese Academy of Medical Sciences, a WHO Cancer Research Center, he came to Yale in 1989. He initially worked with Dr. Yung-chi Cheng (Pharmacology), and joined the faculty in Comparative Medicine in 1994. The current focus of Dr. Yao's work is the biologic function of CSF-1 isoforms in bone remodeling and the regulation of CSF-1 gene expression by PTH and TNF. To explore the role of the cell surface isoform of CSF in bone, targeted overexpression of this isoform in transgenic mice has recently been accomplished.
Flow cytometric analysis of PTH-treated osteoblasts
Saos-2 cells were treated with either vehicle or PTH for 24h and analyzed by flow cytometry. Treatment with PTH was associated with an increase in flourescence as compared with untreated cells (Fig. 1).
Examples of some of Dr. Yao's recent publications
- Yao GQ, Corrias S, Chen YC, Identification of two oligodeoxyribonucleotide binding proteins on plasma membranes of human cell lines. Biochem Pharmacol 51:431-436, 1996.
- Sun BH, Mitnick M, Elelson C, Yao GQ, Paliwal I, Insogna KL, Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy. Endocrinology 138:3918-3924, 1997.
- Yao GQ, Sun BH, Hammond E, Spencer E, Horowitz MC, Insogna KL, Weir EC, The cell-surface form of colony-stimulating factor-1 (CSF-1) is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells. J Biol Chem 273:4119-4128, 1998.