Administrative Core


Karl L. Insogna, M.D., Director, YCCMD
Karl Insogna, M.D.  
Dr. Karl L. Insogna, Professor of Medicine in the Department of Medicine (Endocrine), Director, Yale Bone Center, and Director, Yale Core Center for Musculoskeletal Disorders. Well known in the field of bone biology, his research interests range from basic bone cell biology to clinical research in metabolic bone diseases. He is responsible for supervising all the activities of the YCCMD including scientific and administrative affairs. He, together with Dr. Gundberg, manages the Pilot and the Feasibility Studies Program.

Co-Director and Cell Core Director

Mark C. Horowitz, Ph.D., Director, Cell Core

Mark C. Horowitz, Ph.D., Co-Director, YCCMD, and Director, Cell Core

Mark Horowitz, Ph.D.
Professor of Orthopaedics and Rehabilitation. Dr. Horowitz is internationally recognized for his work in cytokine biology and signal transduction and its role in bone metabolism. His research interests include interactions among the skeletal, hematopoietic and immune sysems and is internationally recognized for his work in cytokine biology and signal transduction and its role in bone metabolism.

Pilot and Feasibility Program

Caren Gundberg, Ph.D., Director, Pilot & Feasibility Project
Dr. Caren Gundberg

Dr. Caren Gundberg, Professor, Department of Orthopaedics and Rehabilitation, directs the Pilot and Feasibility Program. Dr. Gundberg is a well-established investigator in the field of bone biology and has wide ranging interests and experience. She has ample experience in reviewing grant proposals, having served as a reviewer of small grants, NSF, North Carolina Biotechnology Institute and Browne Cox Fellowships at Yale. She has been a reviewer for the NCI and the Veterans Administration as well as an ad hoc reviewer for NIH study sections. She is assisted in evaluating Pilot and Feasibility proposals by internal and external review committees chosen for their expertise in scientific areas relevant to the proposals.


Molecular Core

William Philbrick, Ph.D.
Associate Professor of Medicine and Director of the Molecular Core. He is a molecular and cellular biologist with extensive experience in gene expression systems both in cultured cells and in animal models. Bill has been actively involved in training others in the use of the methodologies offered by the Core for the past 15 years. He currently also serves as the Director of the Molecular Core of the Yale Diabetes Endocrine Research Center.

Physiology Core

Thomas O. Carpenter, M.D., Director, Physiology Core, YCCMD
Thomas O. Carpenter, M.D.

Thomas O. Carpenter, M.D., is Director of the Physiology Core. He is a pediatric endocrinologist with a long-standing interest in vitamin and mineral metabolism. He has investigated the regulation of phosphate homeostasis in humans and other mammalian systems throughout his career, with particular attention to the study of clinical disorders of calcium and phosphate metabolism. He has worked extensively in cell culture, as well as both animal and human investigation. He has recently focused attention on the FGF23/FGFR/Klotho system as relates to renal as well as skeletal effects. 


Kathryn Kristofik
Yale School of Medicine
Department of Internal Medicine Section of Endocrinolgy 
333 Cedar St.
PO Box 208020
New Haven Ct. 06520- 8020

Phone (203) 737-2871
Fax (203) 785-6462