The Yale Core Center for Musculoskeletal Disorders is dedicated to fostering research in disorders of skeletal tissue and muscle, with the ultimate goal of improving human health. The Center is particularly interested in supporting the development and comprehensive investigation of animal models of musculoskeletal disorders. Investigators whose interests include cellular models of disease, the investigation of novel physiologic pathways or therapeutic interventions are also welcome. To encourage and sustain these efforts, the Center has established core laboratories with expertise in whole-animal and skeletal-tissue analysis, molecular methods and bone-cell culture. The Center also sponsors a seminar series to highlight research by Core members and a pilot project program that will provide scientific, technical and financial support to investigators whose work is relevant to the Center's mission.