Research

Our faculty members conduct laboratory-based, translational, and clinical research on the rheumatic and autoimmune diseases. 

Laboratory-based and Translational Research

Laboratory and translational research programs are aimed toward understanding the pathogenesis of autoimmune, inflammatory, and infection-related rheumatic diseases, including Lyme disease, and the effects of aging and immunosuppression on human immunity. 

Laboratory-based and translational investigators in rheumatology collaborate closely with other Yale faculty with similar research interests through a variety of interdisciplinary programs in basic science departments, including: the Department of Immunobiology and its Human Translational Immunology Program. Faculty in Immunobiology often serve as mentors for our trainees. 

Outcomes Research

Clinical research activities focus on medical and shared decision-making, outcomes measurement (including a focus on patient-reported outcomes), technology assessment and decision analysis, clinical trials and quality measurement. Our clinical investigators collaborate with faculty members in the Yale School of Public Health, the National Clinician Scholars Program, and the Yale Program on Aging, as well as with national and international leaders in health services research. The Yale Center for Clinical Investigation and the VA CT HealthCare System, West Haven campus, provide infrastructure and support for human subjects research.

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Immune Profiling

Harness recent advances in technology to identify molecular signatures of diverse clinical conditions

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Inflammation and Innate Immunity

The Section of Rheumatology’s research laboratories explore the role of innate immunity and inflammatory pathways in initiating and perpetuating autoimmunity in different rheumatologic...

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Lyme Disease

Lyme borreliosis is an infectious disease caused by the Ixodes tick-transmitted spirochete Borrelia burgdorferi.

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Lupus

An essential part of the Yale Lupus Program is ongoing clinical and translational research, with the goal of better understanding lupus and advancing treatment

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Microbiome Research in Systemic Autoimmune Diseases

The collection of commensal bacteria that permanently colonize humans are called the microbiota and its gene content the microbiome.