Research

Our faculty members conduct laboratory-based, translational, and clinical research on the rheumatic and autoimmune diseases. Laboratory and translational research programs are aimed toward understanding the pathogenesis of autoimmune, inflammatory, and infection-related rheumatic diseases, including Lyme disease, and the effects of aging and immunosuppression on human immunity. Laboratory-based and translational investigators in rheumatology collaborate closely with other Yale faculty with similar research interests through a variety of interdisciplinary programs in basic science departments, including the Department of Immunobiology and its Human Translational Immunology Program. Faculty in Immunobiology often serve as mentors for our trainees. Clinical research focuses on medical decision-making, outcomes, and quality measures in healthcare delivery, with clinical investigators collaborating with a number of faculty members in the Yale School of Public Health the Robert Wood Johnson Clinical Scholars Program, and the Yale Program on Aging. The Yale Center for Clinical Investigation and the VA CT HealthCare System, West Haven campus, provide infrastructure and support for human subjects research.

Training faculty for our fellows and students are listed below, with their research interests and accomplishments, although we encourage our trainees to work with a variety of highly qualified mentors across the Yale School of Medicine and Yale University.

Bockenstedt, Linda Kathryn

Harold W. Jockers Professor of Medicine (Rheumatology)
Associate Dean, Faculty Development and Diversity

Research Interests: Pathogenesis of Lyme disease; Tick-borne infections; Innate immunity; Multiphoton imaging; Faculty development in context of team science

  • Office: (203) 785-2453
  • Lab: (203) 785-7661

Bucala, Richard

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology and Residential College Associate Fellow in Faculty of Arts and Sciences

Research Interests: Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of the MIF cytokine family; MIF's role in malaria and global infectious diseases; Pharmacologic immuniomodulation of the MIF pathway; Role of fibrocytes in different systemic fibroses

  • Office: (203) 785-2453
  • Lab: (203) 737-5103

Chen, Lieping

United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)
Director, Cancer Immunology Program at Yale Cancer Center

Research Interests: Lymphocyte activation and tolerance; Costimulation and coinhibition; Tumor site immune modulation; Immunotherapy of advanced human cancer; Immunotherapy of advanced autoimmune diseases

  • Office: (203) 737-6338

Concato, John

Professor of Medicine (General Medicine)
Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Research Interests: Screening, prognosis, and treatment strategies; improving methods of research design and statistical analysis

  • Office: (203) 932-5711 x2993

Fikrig, Erol

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis
Investigator, Howard Hughes Medical Institute
Section Chief, Infectious Diseases

Research Interests: Vector-borne diseases; Lyme disease; Human granulocytic ehrilichiosis; West Nile virus

  • Office: (203) 785-4140
  • Appt: (203) 785-2454

Flavell, Richard A

Sterling Professor of Immunobiology
Investigator, Howard Hughes Medical Institute
Department Chair, Immunobiology

Research Interests: Animal Models; Autoimmunity; Diabetes; Gene Expression; Gene Transfer; Genes; Immune System; Lyme Borreliosis Or Lyme Disease; Molecular Cellular Entities; Recombinant DNA; Transgenic Animals; Autoimmunity; Knockout Mice; Lyme Disease; T Cell Lineages; Tolerance; Transgenic Mice

  • Office: (203) 737-2216

Fraenkel, Liana

Associate Professor of Medicine (Rheumatology)
Section Chief of Rheumatology, CT Veterans Administration Medical Center

Research Interests: Epidemiology, provision of health services in rheumatic disease

  • Office: (203) 932-5711 x5914
  • Appt: (203) 737-5430

Fried, Terri R

Professor of Medicine (Geriatrics)

Research Interests: Treatment decision-making; Preferences; Advance care planning; Multiple conditions

  • Office: (203) 932-5711 x5412
  • Appt: (203) 688-6361

Gill, Thomas Michael

Humana Professor of Medicine (Geriatrics) and Professor of Epidemiology (Chronic Diseases) and of Investigative Medicine
Director, Yale Program on Aging
Director, Claude D. Pepper Older Americans Independence Center
Director, Yale Center for Disability and Disabling Disorders
Director, Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research

Research Interests: Epidemiology and prevention of functional decline; Disability among community-living older persons; functional assessment; clinical trials

  • Office: (203) 688-9423
  • Appt: (203) 688-6361

Goldstein, Daniel Robert

Professor of Medicine (Cardiology) and of Immunobiology

Research Interests: Immunity in transplantation; Impact of aging on inflammation and immunity

  • Office: (785) 224-7853
  • Appt: (203) 785-7191

Herold, Kevan

Professor of Immunobiology and of Medicine (Endocrinology)
Deputy Director for Translational Science, YCCI
Director, Yale Diabetes Center

Research Interests: Type 1 diabetes; Immune therapy; Autoimmunity

  • Office: (203) 785-6507
  • Appt: (203) 737-1932

Iwasaki, Akiko

Professor of Immunobiology and of Molecular, Cellular, and Developmental Biology
Professor of Molecular Cellular and Developmental Biology
Howard Hughes Medical Investigator

Research Interests: Innate immunity; Autophagy; Inflammasomes; Sexually transmitted infections; Herpes simplex virus; Human papillomavirus; Respiratory virus infections; Influenza infection; T cell immunity; Commensal bacteria

  • Office: (203) 785-2919
  • Lab: (203) 785-7662

Kaech, Susan

Associate Professor of Immunobiology
HHMI Early Career Scientist

Research Interests: Mechanisms of memory T cell development; Developmental Biology; Immunobiology; Immunology; Vaccine; Immunobiology; T-Cells; Vaccines; Adaptive immunity and immunological memory to viruses

  • Office: (203) 737-2423
  • Lab: (203) 785-7661

Kang, Insoo

Associate Professor of Medicine (Rheumatology)
Course Director, Rheumatology Grand Rounds

Research Interests: Human T cell biology; Immunosenescence; Autoimmunity

  • Office: (203) 785-6678
  • Appt: (203) 737-5430

Krumholz, Harlan M

Harold H. Hines Jr. Professor of Medicine (Cardiology) and Professor of Faculty of Arts and Sciences, of Investigative Medicine and of Public Health (Health Policy)
Co-Director, Clinical Scholars Program
Director, Yale-New Haven Hospital Center for Outcomes Research and Evaluation

Research Interests: Outcomes research in cardiovascular disease

  • Office: (203) 764-5885

Mamula, Mark Joseph

Professor of Medicine (Rheumatology)

Research Interests: Autoimmune diseases

  • Office: (203) 737-2840

Medzhitov, Ruslan M

David W. Wallace Professor of Immunobiology
Investigator, Howard Hughes Medical Institute

Research Interests: Inflammation; Allergy; Immunology; Innate Immunity; Pathophysiology

  • Office: (203) 785-7541

Meffre, Eric RF

Associate Professor of Immunobiology and of Medicine (Immunology)

Research Interests: Human B-cell tolerance; Primary immunodeficiencies; Autoimmune diseases

  • Office: (203) 737-4535

Montgomery, Ruth R

Associate Professor of Medicine (Rheumatology)

Research Interests: Innate Immunity; Macrophage; Neutrophil; Aging; West Nile Virus; Lyme Disease

  • Office: (203) 785-7039
  • Lab: (203) 785-6955

Pober, Jordan Stuart

Bayer Professor of Translational Medicine
Director, Human and Translational Immunology Program
Vice-Chair, Dept. of Immunobiology for the Section of Human and Translational Immunology

Research Interests: Immunobiology of vascular endothelial cells; Cytokine actions and mechanisms; Transplantation immunology

  • Office: (203) 737-2292

Rothlin, Carla Vanina

Assistant Professor of Immunobiology

Research Interests: Regulation of inflammation; Homeostatic control of the immune system

  • Office: (203) 737-4679

Shaw, Albert C

Associate Professor of Medicine (Infectious Diseases)

Research Interests: Mechanisms underlying the functional decline of the immune system with aging

  • Office: (203) 785-3571

Shlomchik, Warren D

Professor of Medicine (Hematology), of Immunobiology and of Medicine (FY15 Hematology)

Research Interests: Mechanisms of antigen presentation; T cell effector function; Regulation of Graft-vs.-Host Disease and Graft-vs.-Leukemia

  • Office: (203) 737-2478
  • Appt: (203) 200-4363

Su, Bing

Associate Professor of Immunobiology

Research Interests: MAP Kinase pathways; mTOR regulation; Receptor signaling; Cell growth control; Lymphocyte development and differentiation

  • Office: (203) 737-2463

Suter, Lisa Gale

Assistant Professor of Medicine (Rheumatology) and of Faculty of Arts and Sciences
Associate Director, Quality Measurement Program, Center for Outcomes Research & Evaluation (CORE)

Research Interests: Quality measurement; Quality improvement; Technology assessment

  • Office: (203) 785-2453

Tinetti, Mary Elizabeth

Gladys Phillips Crofoot Professor of Medicine (Geriatrics) and Professor of Epidemiology (Chronic Diseases), of Faculty of Arts and Sciences and of Investigative Medicine
Section Chief, Geriatrics

Research Interests: Falls and injuries; Mobility; Clinical decision-making in the face of multiple health conditions; Harms and benefits of medications

  • Office: (203) 688-5238
  • Appt: (203) 688-6361