Research

Our faculty members conduct laboratory-based, translational, and clinical research on the rheumatic and autoimmune diseases. Laboratory and translational research programs are aimed toward understanding the pathogenesis of autoimmune, inflammatory, and infection-related rheumatic diseases, including Lyme disease, and the effects of aging and immunosuppression on human immunity. Laboratory-based and translational investigators in rheumatology collaborate closely with other Yale faculty with similar research interests through a variety of interdisciplinary programs in basic science departments, including the Department of Immunobiology and its Human Translational Immunology Program. Faculty in Immunobiology often serve as mentors for our trainees. Clinical research focuses on medical decision-making, outcomes, and quality measures in healthcare delivery, with clinical investigators collaborating with a number of faculty members in the Yale School of Public Health the Robert Wood Johnson Clinical Scholars Program, and the Yale Program on Aging. The Yale Center for Clinical Investigation and the VA CT HealthCare System, West Haven campus, provide infrastructure and support for human subjects research.

Training faculty for our fellows and students are listed below, with their research interests and accomplishments, although we encourage our trainees to work with a variety of highly qualified mentors across the Yale School of Medicine and Yale University.

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Linda Kathryn Bockenstedt, MD

Harold W. Jockers Professor of Medicine (Rheumatology)

Associate Dean, Faculty Development and Diversity

Research Interests

Faculty; Immunity, Innate; Lyme Disease; Lyme Neuroborreliosis; Rheumatology; Tick-Borne Diseases

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Richard Bucala, MD, PhD

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology

Research Interests

Africa; Communicable Diseases, Emerging; Epidemiology; Global Health; Infectious Disease Medicine; Macrophage Migration-Inhibitory Factors; Malaria; Pathology; Public Health; Rheumatology; Stem Cells

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Lieping Chen, MD, PhD

United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)

Co-Director, Cancer Immunology Program at Yale Cancer Center

Research Interests

Allergy and Immunology; Autoimmunity; Dermatology; Immunotherapy; Inflammation; Lymphocyte Activation; Lymphocytes; Medical Oncology; Neoplasms

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John Concato, MD

Professor of Medicine (General Medicine)

Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Research Interests

Epidemiology; Internal Medicine; Prognosis; Research Design

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Joseph Edgar Craft, MD

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology

Section Chief, Rheumatology

Program Director, Investigative Medicine

Paul B. Beeson Professor of Medicine

Research Interests

Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Biology; Cytokines; Immunity; Investigative Techniques; Lupus Erythematosus, Systemic; Rheumatology

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Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis

Investigator, Howard Hughes Medical Institute

Section Chief, Infectious Diseases

Research Interests

Bacteria; Borrelia burgdorferi; Ehrlichiosis; Epidemiology; Global Health; Infectious Disease Medicine; Lyme Disease; Parasitology; Public Health; Ticks; Viruses; West Nile virus

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Richard A Flavell, PhD, FRS

Sterling Professor of Immunobiology

Investigator, Howard Hughes Medical Institute

Research Interests

Autoimmunity; Biology; Cell Lineage; Diabetes Mellitus; DNA, Recombinant; Gene Expression; Gene Transfer Techniques; Immune System; Immunity; Lyme Disease; Lyme Neuroborreliosis; Mice, Knockout

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Liana Fraenkel, MD, MPH

Professor of Medicine (Rheumatology)

Section Chief of Rheumatology, CT Veterans Administration Medical Center

Research Interests

Decision Making; Decision Making, Computer-Assisted; Epidemiology; Patient Preference; Rheumatology; Veterans

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Terri R Fried, MD

Professor of Medicine (Geriatrics)

Research Interests

Advance Care Planning; Decision Making; Geriatrics; Health Care; Patient Preference

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Patrick G Gallagher, MD

Professor of Pediatrics (Neonatology), of Genetics and of Pathology

Director, Yale Center for Blood Disorders

Research Interests

Anemia, Sickle Cell; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Neonatology; Pathology; Pediatrics; Spherocytosis, Hereditary

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