Research

Our faculty members conduct laboratory-based, translational, and clinical research on the rheumatic and autoimmune diseases. Laboratory and translational research programs are aimed toward understanding the pathogenesis of autoimmune, inflammatory, and infection-related rheumatic diseases, including Lyme disease, and the effects of aging and immunosuppression on human immunity. Laboratory-based and translational investigators in rheumatology collaborate closely with other Yale faculty with similar research interests through a variety of interdisciplinary programs in basic science departments, including the Department of Immunobiology and its Human Translational Immunology Program. Faculty in Immunobiology often serve as mentors for our trainees. Clinical research focuses on medical decision-making, outcomes, and quality measures in healthcare delivery, with clinical investigators collaborating with a number of faculty members in the Yale School of Public Health the Robert Wood Johnson Clinical Scholars Program, and the Yale Program on Aging. The Yale Center for Clinical Investigation and the VA CT HealthCare System, West Haven campus, provide infrastructure and support for human subjects research.

Training faculty for our fellows and students are listed below, with their research interests and accomplishments, although we encourage our trainees to work with a variety of highly qualified mentors across the Yale School of Medicine and Yale University.

Bio Profile

Linda Bockenstedt, MD

Harold W. Jockers Professor of Medicine (Rheumatology)

Associate Dean, Faculty Development and Diversity

Research Interests

Faculty; Immunity, Innate; Lyme Disease; Rheumatology; Tick-Borne Diseases; Lyme Neuroborreliosis

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Richard Bucala, MD, PhD

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology

Research Interests

Africa; Epidemiology; Macrophage Migration-Inhibitory Factors; Malaria; Pathology; Public Health; Rheumatology; Stem Cells; Global Health; Communicable Diseases, Emerging; Infectious Disease Medicine

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Lieping Chen, MD, PhD

United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)

Co-Director, Cancer Immunology Program at Yale Cancer Center

Research Interests

Allergy and Immunology; Dermatology; Immunotherapy; Inflammation; Lymphocyte Activation; Lymphocytes; Medical Oncology; Neoplasms; Autoimmunity

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John Concato, MD

Professor of Medicine (General Medicine)

Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Research Interests

Epidemiology; Internal Medicine; Prognosis; Research Design

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Joseph Craft, MD

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology

Section Chief, Rheumatology

Program Director, Investigative Medicine

Paul B. Beeson Professor of Medicine

Research Interests

Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Biology; Immunity; Lupus Erythematosus, Systemic; Investigative Techniques; Rheumatology; Cytokines

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Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis

Section Chief, Infectious Diseases

Research Interests

Bacteria; Epidemiology; Lyme Disease; Parasitology; Public Health; Ticks; Viruses; West Nile virus; Global Health; Ehrlichiosis; Borrelia burgdorferi; Infectious Disease Medicine

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Richard Flavell, PhD, FRS

Sterling Professor of Immunobiology

Investigator, Howard Hughes Medical Institute

Chairman, Department of Immunobiology

Research Interests

Biology; Diabetes Mellitus; DNA, Recombinant; Immune System; Immunity; Lyme Disease; Autoimmunity; Gene Expression; Gene Transfer Techniques; Mice, Knockout; Cell Lineage; Lyme Neuroborreliosis

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Liana Fraenkel, MD, MPH

Professor of Medicine (Rheumatology)

Section Chief of Rheumatology, CT Veterans Administration Medical Center

Research Interests

Decision Making; Decision Making, Computer-Assisted; Epidemiology; Rheumatology; Veterans; Patient Preference

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Terri Fried, MD

Professor of Medicine (Geriatrics)

Research Interests

Decision Making; Geriatrics; Advance Care Planning; Patient Preference; Health Care

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Patrick Gallagher, MD

Professor of Pediatrics (Neonatology), of Genetics and of Pathology

Director, Yale Center for Blood Disorders

Research Interests

Anemia, Sickle Cell; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Neonatology; Pathology; Pediatrics; Spherocytosis, Hereditary