John Peter Concato MD
Professor of Medicine (General Medicine); Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System
Screening, prognosis, and treatment strategies; Improving methods of research design and statistical analysis
As a general internist and clinical epidemiologist, I conduct research to address unanswered questions related to screening, prognosis, and treatment strategies, as well as to improve methods of research design and statistical analysis. This dual focus has involved a range of topics in both patient care and methodology; e.g., evaluating the effectiveness of medical interventions, identifying sources of bias in patient-oriented research, and assessing limitations of popular methods of statistical analysis.
Representative projects include evaluating the effectiveness of screening for prostate cancer, with corresponding refinement of observational methods for evaluating screening tests in general. Other projects have compared the results of observational studies and randomized trials, disputing prior claims of a simple "research design hierarchy." Ongoing work involves studies of prognosis in prostate cancer, and clarifying the use of multivariable analysis in patient-oriented research.