The ambulatory medicine didactic curriculum of the Yale Primary Care Residency is among the most comprehensive and effective seminar series offered in any training program. Organized around 12 recurring outpatient medicine themes, the curriculum features lectures, interactive seminars, peer teaching, self-directed and experiential learning, workshops, and off-site experiences. By way of example, two recent theme day schedules are detailed below. Current theme days in the 2013/2014 academic year include: psychosocial medicine, pain and addiction medicine, quality improvement, health care systems (local and national), infectious disease, endocrine-bone disease, practice management, renal disease, rheumatology, ultrasound training, medical education, and primary care dermatology. In addition to the focused thematic content on a given day, there are a number of longitudinal experiences that intercalate into several consecutive Friday theme days. These include the Evidence-Based Medicine Curriculum, the Musculoskeletal Workshop Series, and the Biostatistics Mini-Course, as detailed below.