The ambulatory medicine didactic curriculum of the Yale Primary Care Residency is among the most comprehensive and effective seminar series offered in any training program. Organized around 12 recurring outpatient medicine themes, the curriculum features lectures, interactive seminars, peer teaching, self-directed and experiential learning, workshops, and off-site experiences. By way of example, two recent theme day schedules are detailed below. Additional theme days in the 2012/2013 academic year include: psychosocial medicine, geriatrics, health care systems (local and national), infectious disease, thyroid disease, renal disease/nephrolithiasis, home visits/transitions of care, primary care ophthalmology, and primary care dermatology/skin biopsy. In addition to the focused thematic content on a given day, there are a number of longitudinal experiences that intercalate into several consecutive Friday theme days. These include the Evidence-Based Medicine curriculum, the Musculoskeletal Workshop Series, and the Biostatistics Mini-Course, as detailed below.